Ring Finger Protein 43 Proteins (RNF43)

Human Ring Finger Protein 43 (RNF43) interaction partners

1. Wnt signalling activation by RNF43 mutations during the tumourigenic stage enhances tumour growth and promotes a high recurrence rate in colorectal cancer.

2. The study found that an SNP (rs2257205) of the RNF43 X117 site was associated with overall survival in a Chinese Colorectal Cancer Cohort.

3. The proportion of mutant RNF43 in Lynch syndrome related colorectal cancers is significantly lower than the previously reported mutation rate found in sporadic microsatellite unstable colorectal cancers. These findings identify further genetic differences between sporadic and hereditary colorectal cancers.

4. results establish that RSPO2, without the LGR4/5/6 receptors, serves as a direct antagonistic ligand to RNF43 and ZNRF3, which together constitute a master switch that governs limb specification; these findings have direct implications for regenerative medicine and WNT-associated cancers

5. Data suggest that inactivation of RNF43 and ZNRF3 is important in serrated tumorigenesis and has identified a potential therapeutic strategy for this cancer subtype.

6. Chimeric transcript resulting from the fusion of RNF43 and SUPT4H1 was found to occur frequently in primary colorectal carcinoma.

7. RNF43 mutation constitutes an important mutated driver gene for the Serrated Neoplasia pathway in both the sporadic and familial Polyposis settings.

8. RNF43 is down-regulated in intrahepatic cholangiocarcinoma and may play a crucial role during development of ICC.

9. The finding of RNF43 mutation in sessile serrated adenoma and traditional serrated adenoma, but not in tubulovillous/villous adenoma, indicated that RNF43 mutation is an early and specific molecular aberration in the serrated colorectal carcinoma pathway.

10. Mutations and downregulation of RNF43 may play a critical role in the transition from adenoma to carcinoma.

11. PTPRK-RSPO3 fusions and RNF43 mutations were found to be characteristic genetic features of traditional serrated adenomas (TSAs).

12. our study exhibited the expression patterns and correlation of RNF43 and p53 pathway proteins involved in cell cycling

13. Authors also identified ring finger 43 (RNF43), an inhibitor of Wnt/beta-catenin signaling, as a target of miR-550a-5p.

14. RNF43 inhibits the Wnt pathway downstream of oncogenic mutations that activate the pathway.

15. RNF43 might act as a tumor suppressor in gastric carcinoma and might be a potential indicator for the clinical assessment of gastric cancer prognosis

16. RNF43 gene harbored not only exceedingly high mutations but also mutational intratumoral heterogeneity, which together might play a role in tumorigenesis of gastric and colorectal cancers.

17. The nucleoprotein of influenza A virus targets RNF43 to modulate p53 ubiquitination levels and hence causes p53 stabilization which is conducive to an enhanced apoptosis level in the host cells.

18. we found that the decreased expression of RNF43 in glioma was associated with poor prognosis by the Kaplan-Meier survival analysis. Importantly, multivariate analysis suggested RN43 as an independent predictor of overall survival.

19. These results indicate that RNF43 mutation might cause downregulation of the expression of ring finger protein 43 and play a crucial role during development of intraductal papillary mucinous neoplasm of the pancreas.

20. Data indicate Dishevelled (DVL) as a dual function adaptor to recruit negative regulators ZNRF3/RNF43 to Wnt receptors to ensure proper control of pathway activity.

Mouse (Murine) Ring Finger Protein 43 (RNF43) interaction partners

1. Wnt signalling activation by RNF43 mutations during the tumourigenic stage enhances tumour growth and promotes a high recurrence rate in colorectal cancer.

2. RSPO-LGR4/5-ZNRF3/RNF43 module controls metabolic liver zonation and is a hepatic growth/size rheostat during development, homeostasis and regeneration.

3. RNF43 and ZNRF3 reduce Wnt signals by selectively ubiquitinating frizzled receptors, thereby targeting these Wnt receptors for degradation