Ring Finger Protein 43 Proteins (RNF43)

RNF43 is a HAP95 (AKAP8L\; MIM 609475) binding ubiquitin ligase that promotes cell growth and is upregulated in colon cancer (Yagyu et al., 2004 [PubMed 15492824]\; Sugiura et al., 2008 [PubMed 18313049]).[supplied by OMIM, Dec 2008].. Additionally we are shipping RNF43 Antibodies (31) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RNF43 54894 Q68DV7
RNF43 207742 Q5NCP0
Rat RNF43 RNF43 303412  
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Top RNF43 Proteins at antibodies-online.com

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
$5,370.21
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
$9,626.73
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
$5,370.21
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg 60 to 65 Days
$7,506.65
Details
Human Cells Human Fc Tag 100 μg 14 to 16 Days
$440.65
Details
Human Cells Human His tag 100 μg 14 to 16 Days
$440.65
Details

RNF43 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
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Mouse (Murine) ,
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More Proteins for Ring Finger Protein 43 (RNF43) Interaction Partners

Human Ring Finger Protein 43 (RNF43) interaction partners

  1. Wnt signalling activation by RNF43 mutations during the tumourigenic stage enhances tumour growth and promotes a high recurrence rate in colorectal cancer.

  2. The study found that an SNP (rs2257205) of the RNF43 X117 site was associated with overall survival in a Chinese Colorectal Cancer Cohort.

  3. The proportion of mutant RNF43 in Lynch syndrome related colorectal cancers is significantly lower than the previously reported mutation rate found in sporadic microsatellite unstable colorectal cancers. These findings identify further genetic differences between sporadic and hereditary colorectal cancers.

  4. results establish that RSPO2, without the LGR4/5/6 receptors, serves as a direct antagonistic ligand to RNF43 and ZNRF3, which together constitute a master switch that governs limb specification; these findings have direct implications for regenerative medicine and WNT-associated cancers

  5. Data suggest that inactivation of RNF43 and ZNRF3 is important in serrated tumorigenesis and has identified a potential therapeutic strategy for this cancer subtype.

  6. Chimeric transcript resulting from the fusion of RNF43 and SUPT4H1 was found to occur frequently in primary colorectal carcinoma.

  7. RNF43 mutation constitutes an important mutated driver gene for the Serrated Neoplasia pathway in both the sporadic and familial Polyposis settings.

  8. RNF43 is down-regulated in intrahepatic cholangiocarcinoma and may play a crucial role during development of ICC.

  9. The finding of RNF43 mutation in sessile serrated adenoma and traditional serrated adenoma, but not in tubulovillous/villous adenoma, indicated that RNF43 mutation is an early and specific molecular aberration in the serrated colorectal carcinoma pathway.

  10. Mutations and downregulation of RNF43 may play a critical role in the transition from adenoma to carcinoma.

  11. PTPRK-RSPO3 fusions and RNF43 mutations were found to be characteristic genetic features of traditional serrated adenomas (TSAs).

  12. our study exhibited the expression patterns and correlation of RNF43 and p53 pathway proteins involved in cell cycling

  13. Authors also identified ring finger 43 (RNF43), an inhibitor of Wnt/beta-catenin signaling, as a target of miR-550a-5p.

  14. RNF43 inhibits the Wnt pathway downstream of oncogenic mutations that activate the pathway.

  15. RNF43 might act as a tumor suppressor in gastric carcinoma and might be a potential indicator for the clinical assessment of gastric cancer prognosis

  16. RNF43 gene harbored not only exceedingly high mutations but also mutational intratumoral heterogeneity, which together might play a role in tumorigenesis of gastric and colorectal cancers.

  17. The nucleoprotein of influenza A virus targets RNF43 to modulate p53 ubiquitination levels and hence causes p53 stabilization which is conducive to an enhanced apoptosis level in the host cells.

  18. we found that the decreased expression of RNF43 in glioma was associated with poor prognosis by the Kaplan-Meier survival analysis. Importantly, multivariate analysis suggested RN43 as an independent predictor of overall survival.

  19. These results indicate that RNF43 mutation might cause downregulation of the expression of ring finger protein 43 and play a crucial role during development of intraductal papillary mucinous neoplasm of the pancreas.

  20. Data indicate Dishevelled (DVL) as a dual function adaptor to recruit negative regulators ZNRF3/RNF43 to Wnt receptors to ensure proper control of pathway activity.

Mouse (Murine) Ring Finger Protein 43 (RNF43) interaction partners

  1. Wnt signalling activation by RNF43 mutations during the tumourigenic stage enhances tumour growth and promotes a high recurrence rate in colorectal cancer.

  2. RSPO-LGR4/5-ZNRF3/RNF43 module controls metabolic liver zonation and is a hepatic growth/size rheostat during development, homeostasis and regeneration.

  3. RNF43 and ZNRF3 reduce Wnt signals by selectively ubiquitinating frizzled receptors, thereby targeting these Wnt receptors for degradation

RNF43 Protein Profile

Protein Summary

RNF43 is a HAP95 (AKAP8L\; MIM 609475) binding ubiquitin ligase that promotes cell growth and is upregulated in colon cancer (Yagyu et al., 2004

Gene names and symbols associated with Ring Finger Protein 43 Proteins (RNF43)

  • ring finger protein 43 (RNF43)
  • ring finger protein 43 (Rnf43)
  • 4732452J19Rik protein
  • RGD1305204 protein
  • RNF124 protein
  • URCC protein

Protein level used designations for Ring Finger Protein 43 Proteins (RNF43)

E3 ubiquitin-protein ligase RNF43 , RING finger protein 43

GENE ID SPECIES
100057001 Equus caballus
54894 Homo sapiens
491114 Canis lupus familiaris
784035 Bos taurus
207742 Mus musculus
303412 Rattus norvegicus
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