Roundabout, Axon Guidance Receptor, Homolog 3 (Drosophila) (ROBO3) ELISA Kits

ROBO3 is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. Additionally we are shipping ROBO3 Antibodies (89) and ROBO3 Proteins (8) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
ROBO3 64221 Q96MS0
Anti-Rat ROBO3 ROBO3 315564  
Anti-Mouse ROBO3 ROBO3 19649  
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Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 50 pg/mL 0.06 ng/mL - 15 ng/mL 96 Tests Log in to see 3 to 4 Days
Human 0.06 ng/mL 15-0.06 ng/mL 96 Tests Log in to see 2 to 3 Days

More ELISA Kits for ROBO3 Interaction Partners

Human Roundabout, Axon Guidance Receptor, Homolog 3 (Drosophila) (ROBO3) interaction partners

  1. confirmed that ROBO3 increases with clinical grade and miR (show MLXIP ELISA Kits)-383 expression is inversely correlated to that of ROBO3

  2. human AKAP79-anchored PKC selectively phosphorylates the Robo3.1 receptor subtype on serine 1330

  3. We report the case of a 10-month-old girl with cross-fixation and inability to abduct who was genetically proven to have horizontal gaze palsy with progressive scoliosis (recessive ROBO3 mutations).

  4. Robo3.1A may prevent the Slit responsiveness by recruiting Robo1 (show ROBO1 ELISA Kits)/2 into a late endosome- and lysosome-dependent degradation pathway.

  5. The novel ROBO3 mutation in this family may be among the most deleterious

  6. This patient had clinical and neuroimaging characteristics considered pathognomonic of horizontal gaze palsy and progressive scoliosis and yet did not have ROBO3 mutations

  7. Three novel ROBO3 mutations have been identified in consanguineous patients with horizontal gaze palsy and progressive scoliosis.

  8. RIG-I (show DDX58 ELISA Kits) or melanoma differentiation-associated gene (MDA)5 (show IFIH1 ELISA Kits) signaling through mitochondrial antiviral signaling protein MAVS (show MAVS ELISA Kits) is required for activation of interferon (show IFNA ELISA Kits) (IFN)-beta (show IFNB1 ELISA Kits) production by rotavirus-infected intestinal epithelial cells.

  9. Slit3 (show SLIT1 ELISA Kits) inhibits Robo3-induced invasion of synovial fibroblasts in rheumatoid arthritis.

  10. mutations in the ROBO3 gene, which shares homology with roundabout (show ROBO1 ELISA Kits) genes important in axon guidance in developing Drosophila, zebrafish, and mouse.

Fruit Fly (Drosophila melanogaster) Roundabout, Axon Guidance Receptor, Homolog 3 (Drosophila) (ROBO3) interaction partners

  1. Data show that Robo and Robo2 promote midline repulsion, while Robo2 and Robo3 specify the position of longitudinal axon pathways.

  2. The transient cell-specific expression of Robo3 plays a crucial role in establishing neural circuits in the Drosophila visual system by selectively regulating pathway choice for posterior-most R8 growth cones.

  3. Robo3 expression is one of a suite of chordotonal neuron properties that depend on expression of the proneural gene atonal.

  4. robo, robo2, and robo3 play a role in the guidance of sensory axons in the Drosophila embryo by both slit-dependent and slit-independent mechanisms.

  5. axon guidance molecules roundabout2 and roundabout3 (robo2/3) are necessary for serotonergic neuron differentiation

Xenopus laevis Roundabout, Axon Guidance Receptor, Homolog 3 (Drosophila) (ROBO3) interaction partners

  1. Slit acts via Robo2 (show ROBO2 ELISA Kits) in dendrites as a branching/growth factor but not in guidance, while Robo2 (show ROBO2 ELISA Kits) and Robo3 function in concert in axons to mediate axonal interactions and respond to Slits as guidance factors

Mouse (Murine) Roundabout, Axon Guidance Receptor, Homolog 3 (Drosophila) (ROBO3) interaction partners

  1. This study show that this commissural neuron population includes spinal inhibitory neurons and sensory nociceptors and show that this population depends on Robo/Slit signaling yet crosses the dorsal midline in a Robo3-independent manner.

  2. These findings identify NELL2 (show NELL2 ELISA Kits) as an axon guidance cue and establish Robo3 as a multifunctional regulator of pathfinding that simultaneously mediates NELL2 (show NELL2 ELISA Kits) repulsion, inhibits Slit repulsion, and facilitates Netrin attraction to achieve a common guidance purpose.

  3. results suggest that Robo3 evolution was key to sculpting the mammalian brain by converting a receptor for Slit repulsion into one that both silences Slit repulsion and potentiates Netrin attraction

  4. this study demonistrated that Robo3-driven axon midline crossing conditions functional maturation of a large commissural synapse.

  5. Rerouting climbing fibers to an ipsilateral projection reversed complex-spike modulation. Ptf1a (show PTF1A ELISA Kits)::cre;Robo3(lox/lox (show LOX ELISA Kits)) mice showed severe ataxia indicating the impact of climbing fi ber input on reciprocity of Purkinje cell fi ring during motor coordination.

  6. Posttranscriptional regulation of Robo3 mediated by Musashi-1 (show MSI1 ELISA Kits) controls midline crossing of precerebellar neurons.

  7. Pax-2/RB binding reverses repression of Rig-1 protein.

  8. The Slit receptors Robo2 (show ROBO2 ELISA Kits) and Robo3/Rig-1 are expressed in the subventricular zone and the rostral migratory stream and Slit1 (show SLIT1 ELISA Kits) and Slit2 (show SLIT2 ELISA Kits) are present in the adult septum and are responsible for both the septum and the CP repulsive activity in vitro

  9. Expression of Rig-1 protein by commissural axons is inversely correlated with Slit sensitivity. Removal of Rig-1 results in a total failure of commissural axons to cross.

  10. two functionally antagonistic isoforms of Robo3 with distinct carboxy termini arising from alternative splicing have been found

Zebrafish Roundabout, Axon Guidance Receptor, Homolog 3 (Drosophila) (ROBO3) interaction partners

  1. In the absence of Sim1a and Arnt2 (show ARNT2 ELISA Kits), expression of robo3 splice isoform robo3a.1 is increased in the hypothalamus, indicating negative control of robo3a.1 transcription by these factors.

  2. Slit-Robo signaling downregulates N-cadherin (show CDH2 ELISA Kits) activity to allow apical retraction in newly generated retinal ganglion cells.

  3. These results demonstrate a key role for Robo-Slit signaling in vertebrate longitudinal axon guidance; Robo1 (show ROBO1 ELISA Kits) and Robo3 restricted the extent of defasciculation of the tract of the postoptic commissure.

  4. The Mauthner neurons are essential for the startle response, and in twitch twice/robo3 mutants misguidance of the Mauthner axons results in a unidirectional startle response.

ROBO3 Antigen Profile

Antigen Summary

This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS)\; an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla. Alternative transcript variants have been described but have not been experimentally validated.

Gene names and symbols associated with ROBO3

  • roundabout guidance receptor 3 (ROBO3) antibody
  • roundabout 3 (robo3) antibody
  • roundabout guidance receptor 3 (Robo3) antibody
  • robo3 (LOC658818) antibody
  • roundabout guidance receptor 3 L homeolog (robo3.L) antibody
  • roundabout, axon guidance receptor, homolog 3 (Drosophila) (robo3) antibody
  • cb503 antibody
  • CG5423 antibody
  • CG14345 antibody
  • CT17158 antibody
  • DKFZp468G0223 antibody
  • DmelCG5423 antibody
  • dRobo-3 antibody
  • HGPPS antibody
  • HGPS antibody
  • Rbig1 antibody
  • Rig-1 antibody
  • Rig1 antibody
  • Robo-3 antibody
  • robo3 antibody
  • Robo3a antibody
  • Robo3b antibody

Protein level used designations for ROBO3

retinoblastoma inhibiting gene 1 , roundabout homolog 3 , roundabout-like protein 3 , robo3 , CG5423-PA , robo3-PA , roundabout, axon guidance receptor, homolog 3 , roundabout, axon guidance receptor, homolog 3 (Drosophila) , GLEAN_06743 , roundabout 3 , roundabout homolog 3-like , retinoblastoma-inhibiting gene 1 protein , roundabout (axon guidance receptor, Drosophila) homolog 3 , twi , twitch twice

64221 Homo sapiens
33314 Drosophila melanogaster
315564 Rattus norvegicus
466839 Pan troglodytes
489307 Canis lupus familiaris
658818 Tribolium castaneum
716274 Macaca mulatta
100072287 Equus caballus
100172083 Pongo abelii
100322880 Xenopus laevis
100342258 Oryctolagus cuniculus
100403106 Callithrix jacchus
100524637 Sus scrofa
100588193 Nomascus leucogenys
19649 Mus musculus
100858578 Gallus gallus
100337359 Bos taurus
30770 Danio rerio
100721535 Cavia porcellus
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