ROBO3 ELISA Kits
ROBO3 is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation.
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ROBO3 ELISA Kit (Roundabout, Axon Guidance Receptor, Homolog 3 (Drosophila)) ELISA Kit
ROBO3 IQ-ELISA Kit (Roundabout, Axon Guidance Receptor, Homolog 3 (Drosophila)) IQ-ELISA Kit
ROBO3 ELISA Kit (Roundabout, Axon Guidance Receptor, Homolog 3 (Drosophila)) ELISA Kit
ROBO3 Antigen Profile
Protein Summary
This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS)\; an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla. Alternative transcript variants have been described but have not been experimentally validated.
Gene names and symbols associated with ROBO3
- roundabout guidance receptor 3 (ROBO3) antibody
- roundabout 3 (robo3) antibody
- roundabout guidance receptor 3 (Robo3) antibody
- robo3 (LOC658818) antibody
- roundabout guidance receptor 3 L homeolog (robo3.L) antibody
- roundabout, axon guidance receptor, homolog 3 (Drosophila) (robo3) antibody
- cb503 antibody
- CG5423 antibody
- CG14345 antibody
- CT17158 antibody
- DKFZp468G0223 antibody
- DmelCG5423 antibody
- dRobo-3 antibody
- HGPPS antibody
- HGPS antibody
- Rbig1 antibody
- Rig-1 antibody
- Rig1 antibody
- Robo-3 antibody
- robo3 antibody
- Robo3a antibody
- Robo3b antibody
Protein level used designations for ROBO3
retinoblastoma inhibiting gene 1 , roundabout homolog 3 , roundabout-like protein 3 , robo3 , CG5423-PA , robo3-PA , roundabout, axon guidance receptor, homolog 3 , roundabout, axon guidance receptor, homolog 3 (Drosophila) , GLEAN_06743 , roundabout 3 , roundabout homolog 3-like , retinoblastoma-inhibiting gene 1 protein , roundabout (axon guidance receptor, Drosophila) homolog 3 , twi , twitch twice
| GENE ID | SPECIES |
|---|---|
| 64221 | Homo sapiens |
| 33314 | Drosophila melanogaster |
| 315564 | Rattus norvegicus |
| 466839 | Pan troglodytes |
| 489307 | Canis lupus familiaris |
| 658818 | Tribolium castaneum |
| 716274 | Macaca mulatta |
| 100072287 | Equus caballus |
| 100172083 | Pongo abelii |
| 100322880 | Xenopus laevis |
| 100342258 | Oryctolagus cuniculus |
| 100403106 | Callithrix jacchus |
| 100524637 | Sus scrofa |
| 100588193 | Nomascus leucogenys |
| 19649 | Mus musculus |
| 100858578 | Gallus gallus |
| 100337359 | Bos taurus |
| 30770 | Danio rerio |
| 100721535 | Cavia porcellus |
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