Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) Proteins (RUNX1T1)

RUNX1T1 encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. Additionally we are shipping RUNX1T1 Antibodies (51) and RUNX1T1 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RUNX1T1 862 Q06455
RUNX1T1 12395 Q61909
Rat RUNX1T1 RUNX1T1 362489  
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Top RUNX1T1 Proteins at antibodies-online.com

Showing 4 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$547.80
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$331.20
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RUNX1T1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) Interaction Partners

Human Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) interaction partners

  1. PKM2 (show PKM Proteins) as a novel target of RUNX1 (show RUNX1 Proteins)-ETO and is specifically downregulated in RUNX1 (show RUNX1 Proteins)-ETO positive AML (show RUNX1 Proteins) patients, indicating that PKM2 (show PKM Proteins) level might have a diagnostic potential in RUNX1 (show RUNX1 Proteins)-ETO associated AML (show RUNX1 Proteins).

  2. The specific association of ZBTB7A (show ZBTB7A Proteins) mutations with t(8;21) rearranged acute myeloid leukaemia points towards leukemogenic cooperativity between mutant ZBTB7A (show ZBTB7A Proteins) and the RUNX1 (show RUNX1 Proteins)/RUNX1T1 fusion protein has been reported.

  3. Data indicate miR (show MLXIP Proteins)-29b-1 as a regulator of the AML1 (show RUNX1 Proteins)-ETO protein (RUNX1 (show RUNX1 Proteins)-RUNX1T1), and that miR (show MLXIP Proteins)-29b-1 expression in t(8;21)-carrying leukemic cell lines partially rescues the leukemic phenotype.

  4. Altogether, these results revealed an unexpected and important epigenetic mini-circuit of AML1 (show RUNX1 Proteins)-ETO/THAP10 (show THAP10 Proteins)/miR (show MLXIP Proteins)-383 in t(8;21) acute myeloid leukaemia, in which epigenetic suppression of THAP10 (show THAP10 Proteins) predicts a poor clinical outcome and represents a novel therapeutic target.

  5. RUNX1 (show RUNX1 Proteins)-RUNX1T1 transcript levels were measured in bone marrow samples collected from 208 patients at scheduled time points after transplantation. Over 90% of the 175 patients who were in continuous complete remission had a >/=3-log reduction in RUNX1 (show RUNX1 Proteins)-RUNX1T1 transcript levels from the time of diagnosis at each time point after transplantation and a >/=4-log reduction at >/=12 months.

  6. The data suggest that the tumor suppressor activity of both RUNX1t1 and TFF1 (show TFF1 Proteins) are mechanistically connected to CEBPB (show CEBPB Proteins) and that cross-regulation between CEBPB (show CEBPB Proteins)-RUNX1t1-TFF1 (show TFF1 Proteins) plays an important role in gastric carcinogenesis.

  7. RUNX1T1 serves as a common angiogenic driver for vaculogenesis and functionality of endothelial lineage cells

  8. Leukaemogenesis by AML1 (show RUNX1 Proteins)-ETO requires enhanced C/D box snoRNA/RNP (show RNPC3 Proteins) formation.

  9. Study demonstrated that TRiC's contribution to the activity of the DNA-binding domain (AML1 (show RUNX1 Proteins)-175) of AML1 (show RUNX1 Proteins)-ETO is consistent with its contribution to the activity of full-length AML1 (show RUNX1 Proteins)-ETO and is mediated through its direct association with the DNA-binding domain

  10. the AML1 (show RUNX1 Proteins)-ETO fusion protein increases the expression of SIRT1 (show SIRT1 Proteins), possibly by binding to the promoter region of SIRT1 (show SIRT1 Proteins) to activate its transcription in t(8;21) AML (show RUNX1 Proteins).

Mouse (Murine) Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) interaction partners

  1. Results suggest that AML1 (show RUNX1 Proteins)/ETO expression determines a more mobile and less adherent phenotype in preleukemic cells, therefore altering the interaction with the hematopoietic niche, potentially leading to the migration across the bone marrow barrier and to disease progression

  2. The data suggest that the tumor suppressor activity of both RUNX1t1 and TFF1 (show TFF1 Proteins) are mechanistically connected to CEBPB (show CEBPB Proteins) and that cross-regulation between CEBPB (show CEBPB Proteins)-RUNX1t1-TFF1 (show TFF1 Proteins) plays an important role in gastric carcinogenesis.

  3. RUNX1T1 serves as a common angiogenic driver for vaculogenesis and functionality of endothelial lineage cells

  4. Leukaemogenesis by AML1 (show RUNX1 Proteins)-ETO requires enhanced C/D box snoRNA/RNP (show RNPC3 Proteins) formation.

  5. Data show that RUNX1 (show RUNX1 Proteins)-ETO;c-Kit(T417IDelta418-419) coexpression promoted exclusively acute myeloid leukemia (show BCL11A Proteins) (AML (show RUNX1 Proteins)) in a fraction (51%) of reconstituted mice.

  6. Self-renewal induced by AML1 (show RUNX1 Proteins)/ETO in primary murine progenitors was inhibited when Aes (show AES Proteins) was decreased or absent.

  7. AML1 (show RUNX1 Proteins)-ETO synergizes with an ICSBP (show IRF8 Proteins) deficiency to induce myeloblastic transformation in the bone marrow, reminiscent of acute myelogenous leukemia

  8. molecular role for ETO in normal physiology as an inhibitor of C/EBPbeta (show CEBPB Proteins) and a novel regulator of early adipogenesis

  9. the loss of the molecular events of AML1 (show RUNX1 Proteins)-ETO C-terminal NCoR (show NCOR1 Proteins)/SMRT-interacting domain transforms AML1 (show RUNX1 Proteins)-ETO into a potent leukemogenic protein

  10. p15(Ink4b (show CDKN2B Proteins)) loss must be accompanied by additional oncogenic changes for RUNX1 (show RUNX1 Proteins)-ETO-associated AML (show RUNX1 Proteins) to develop

RUNX1T1 Protein Profile

Protein Summary

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8\;21)(q22\;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with RUNX1T1

  • runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (runx1t1)
  • RUNX1 translocation partner 1 L homeolog (runx1t1.L)
  • RUNX1 translocation partner 1 (RUNX1T1)
  • runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (Runx1t1)
  • RUNX1 translocation partner 1 (Runx1t1)
  • AML1T1 protein
  • Cbfa2t1 protein
  • Cbfa2t1h protein
  • CDR protein
  • ETO protein
  • MTG8 protein
  • si:ch211-232j17.1 protein
  • wu:fi14b07 protein
  • zgc:154044 protein
  • ZMYND2 protein

Protein level used designations for RUNX1T1

protein CBFA2T1 , MTG8 , MTG8/ETOb , expressed during postmitotic spinal neurons, most likely in motorneurons , acute myelogenous leukemia 1 translocation 1, cyclin-D related , core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related , eight twenty one protein , myeloid translocation gene on 8q22 , zinc finger MYND domain-containing protein 2 , CBFA2T1 identified gene homolog , acute myelogenous leukemia 1 translocation 1 protein , core-binding factor, runt domain, alpha subunit 2 , cyclin D-related , translocated to, 1

GENE ID SPECIES
767809 Danio rerio
733153 Xenopus laevis
395503 Gallus gallus
862 Homo sapiens
487044 Canis lupus familiaris
12395 Mus musculus
362489 Rattus norvegicus
100155449 Sus scrofa
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