Runt-Related Transcription Factor 1 (RUNX1) ELISA Kits

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse RUNX1 RUNX1 12394 Q03347
Anti-Human RUNX1 RUNX1 861 Q01196
Anti-Rat RUNX1 RUNX1 50662 Q63046
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top RUNX1 ELISA Kits at antibodies-online.com

Showing 5 out of 11 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Rat 6.25 pg/mL 25-1600 pg/mL Typical standard curve 96 Tests Log in to see 15 to 18 Days
$910.56
Details
Human
  96 Tests Log in to see 2 to 3 Days
$480.00
Details
Human
  96 Tests Log in to see 1 to 2 Days
$898.33
Details
Human
  96 Tests Log in to see 2 to 3 Days
$525.00
Details
Human
  96 Tests Log in to see 2 to 3 Days
$525.00
Details

More ELISA Kits for RUNX1 Interaction Partners

Mouse (Murine) Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Results suggest that AML1/ETO (show RUNX1T1 ELISA Kits) expression determines a more mobile and less adherent phenotype in preleukemic cells, therefore altering the interaction with the hematopoietic niche, potentially leading to the migration across the bone marrow barrier and to disease progression

  2. Gene expression profiling of HEPs revealed a RUNX1c-induced proinflammatory molecular signature, supporting previous studies demonstrating proinflammatory signaling as a regulator of HSC emergence.

  3. Histones showed limited activation in regions of single TF binding, while enhancers that bind NF-E2 and either RUNX1, FLI1 (show FLI1 ELISA Kits) or both TFs gave the highest signals for TF occupancy and H3K4me2; these enhancers associated best with genes activated late in MK maturation.

  4. the ability of Runx1 to induce endothelial-to-hematopoietic transition (EHT) in non-hemogenic endothelial cells depends on the anatomical location of the cell and the developmental age of the conceptus

  5. CDK6 (show CDK6 ELISA Kits) kinase activity negatively regulates the conversion of fat-storing cells into fat-burning cells by suppressing RUNX1, and may be a therapeutic target for the treatment of obesity and related metabolic diseases

  6. RUNX1 dosage plays a pivotal role in hemogenic endothelium maturation and the establishment of the hematopoietic system.

  7. These results suggest that RUNX1 may be an essential modulator in BMP9 (show GDF2 ELISA Kits)- induced osteogenic differentiation of mesenchymal stem cells.

  8. Loss of Runx1 and Runx2 (show RUNX2 ELISA Kits) inhibits prostate cell motility.

  9. In vivo, in vitro and systems biology results show that Runx1 exerts a pro-neurogenic function in neural precursor cells in vitro, while in vivo data remained inconclusive.

  10. High RUNX1 expression is associated with lymphoma.

Human Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Our findings show the profound impact of RUNX1 allele dosage on gene expression profile and glucocorticoid sensitivity in AML, thereby opening opportunities for preclinical testing which may lead to drug repurposing and improved disease characterization.

  2. This study established inducible RUNX1b/c-overexpressing human embryonic stem cell (hESC) lines, in which RUNX1b/c overexpression prevented the emergence of CD34 (show CD34 ELISA Kits)+ cells from early stage, thereby drastically reducing the production of hematopoietic stem/progenitor cells. Simultaneously, the expression of hematopoiesis-related factors was downregulated.

  3. Genome-engineered hPSCs expressing ETV6 (show ETV6 ELISA Kits)-RUNX1 from the endogenous ETV6 (show ETV6 ELISA Kits) locus show expansion of the CD19 (show CD19 ELISA Kits)(-)IL-7R(+) compartment

  4. our study demonstrated that specific bone marrow abnormalities and acquired genetic alterations may be harbingers of progression to hematological malignancies in patients with familial platelet disorder with germline RUNX1 mutation.

  5. These studies provide the first evidence in patients with a RUNX1 mutation for a defect in AH (lysosomal) secretion, and for a global defect in secretion involving all three types of platelet granules that is unrelated to a granule content deficiency. They highlight the pleiotropic effects and multiple platelet defects associated with RUNX1 mutations.

  6. Younger mRUNX1 AML patients treated with intensive chemotherapy experienced inferior treatment outcomes. In older patients with AML treated with hypomethylating agent (HMA) therapy, response and survival was independent of RUNX1 status. Older mRUNX1 patients with prior myelodysplastic syndrome or myeloproliferative neoplasms (MDS (show PAFAH1B1 ELISA Kits)/MPN (show PRSS27 ELISA Kits)) had particularly dismal outcome

  7. Data indicate miR (show MLXIP ELISA Kits)-29b-1 as a regulator of the AML1-ETO (show RUNX1T1 ELISA Kits) protein (RUNX1-RUNX1T1 (show RUNX1T1 ELISA Kits)), and that miR (show MLXIP ELISA Kits)-29b-1 expression in t(8;21)-carrying leukemic cell lines partially rescues the leukemic phenotype.

  8. EBPA and RUNX1 are expressed at higher levels in patients with acute myeloid leukemia (show BCL11A ELISA Kits) in comparison to healthy subjects

  9. The first characterization of this CASC15 in RUNX1-translocated leukemia.

  10. Altogether, these results revealed an unexpected and important epigenetic mini-circuit of AML1-ETO/THAP10/miR-383 in t(8;21) acute myeloid leukaemia, in which epigenetic suppression of THAP10 predicts a poor clinical outcome and represents a novel therapeutic target.

Zebrafish Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Our data suggest that runx1 and cbfb are required at 2 different steps during early hematopoietic stem cell development

  2. We propose that cohesin and CTCF (show CTCF ELISA Kits) have distinct functions in the regulation of runx1 during zebrafish embryogenesis.

  3. Morpholino knockdown of Myef2 (show MYEF2 ELISA Kits) or Runx1 in zebrafish results in reduced numbers of hematopoietic stem cells, suggesting that these two factors also interact in vivo to regulate hematopoiesis.

  4. Runx1 is induced by high Pu.1 level and in turn transrepresses pu.1 expression, thus constituting a negative feedback loop that fashions a favorable Pu.1 level required for balanced fate commitment to neutrophils versus macrophages.

  5. hematopoietic stem cell numbers depended on activity of the transcription factor Runx1, on blood flow, and on proper development of the dorsal aorta

  6. in zebrafish adult HSCs can be formed without an intact runx1.

  7. Zebrafish embryos lacking Rad21, or cohesin subunit Smc3, fail to express runx3 (show RUNX3 ELISA Kits) and lose hematopoietic runx1 expression in early embryonic development.

Xenopus laevis Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Xaml1/Runx1 is required for the specification of Rohon-Beard sensory neurons in Xenopus.

  2. ETV6-RUNX1 (TEL-AML1) fusion and hyperdiploidy (>50 chromosomes) are favorable genetic features in childhood acute lymphoblastic leukemia (ALL).

  3. reveal a shift in Runx2 (show RUNX2 ELISA Kits) function protein during vertebrate evolution towards its exclusive roles in cartilage hypertrophy and bone differentiation within the amniote lineage

RUNX1 Antigen Profile

Antigen Summary

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with RUNX1

  • uncharacterized LOC473981 (LOC473981) antibody
  • runt-related transcription factor (runt) antibody
  • runt related transcription factor 1 (Runx1) antibody
  • runt related transcription factor 1 (RUNX1) antibody
  • runt-related transcription factor 1 (runx1) antibody
  • runt related transcription factor 1 L homeolog (runx1.L) antibody
  • runt-related transcription factor 1 (RUNX1) antibody
  • runt-related transcription factor 1 (Runx1) antibody
  • AI462102 antibody
  • aml antibody
  • aml-1 antibody
  • Aml1 antibody
  • aml1-evi-1 antibody
  • amlcr1 antibody
  • cbfa2 antibody
  • evi-1 antibody
  • Pebp2a2 antibody
  • pebp2ab antibody
  • Pebpa2b antibody
  • Runx-1 antibody
  • runx1 antibody
  • runxa antibody
  • XAML antibody
  • Xaml1 antibody

Protein level used designations for RUNX1

runt-related transcription factor 1 , runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene) , runt-related transcription factor , runt protein , CBF-alpha-2 , PEA2-alpha B , PEBP2-alpha B , SL3-3 enhancer factor 1 alpha B subunit , SL3/AKV core-binding factor alpha B subunit , acute myeloid leukemia 1 protein , core binding factor alpha 2 , core-binding factor subunit alpha-2 , oncogene AML-1 , polyomavirus enhancer-binding protein 2 alpha B subunit , runt domain, alpha subunit 2 , AML1-EVI-1 fusion protein , core-binding factor, runt domain, alpha subunit 2 , aml1 , runt-related transcription factor a , runx1a , Acute myeloid leukemia 1 protein , Core-binding factor subunit alpha-2 , aml1 oncogene , ch-runtB2 , acute myeloid leukemia 1 , factor, runt domain, alpha subunit 2 , core-binding factor runt domain alpha subunit 2 (acute myeloid leukemia 1 oncogene) , runt related transcription factor 1

GENE ID SPECIES
473981 Pan troglodytes
100302713 Saccoglossus kowalevskii
12394 Mus musculus
861 Homo sapiens
58126 Danio rerio
379657 Xenopus laevis
396152 Gallus gallus
487746 Canis lupus familiaris
529631 Bos taurus
50662 Rattus norvegicus
100512633 Sus scrofa
100724149 Cavia porcellus
Did you look for something else?