Runt-Related Transcription Factor 2 Proteins (RUNX2)

RUNX2 is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. Additionally we are shipping RUNX2 Antibodies (253) and RUNX2 Kits (60) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RUNX2 860 Q13950
RUNX2 12393 Q08775
RUNX2 367218  
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Top RUNX2 Proteins at antibodies-online.com

Showing 9 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
$746.00
Details
Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 15 to 18 Days
$784.00
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Log in to see Available
$284.90
Details
Yeast Horse His tag   1 mg Log in to see 60 to 71 Days
$2,271.50
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,541.00
Details
Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 11 to 18 Days
$582.75
Details
Escherichia coli (E. coli) Cow Un-conjugated   5 applications Log in to see 1 to 2 Days
$318.85
Details

RUNX2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine) ,

Rat (Rattus)

More Proteins for Runt-Related Transcription Factor 2 (RUNX2) Interaction Partners

Human Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. Study identified RUNX2 to be targeted by miR (show MLXIP Proteins)-217 which directly bound to RUNX2 mRNA and inhibited its expression in bladder cancer cells. Also, findings demonstrated that RUNX2 expression was upregulated by hsa_circ_0000144. Moreover, rescue assays demonstrated that RUNX2 was a downstream effector molecule of hsa_circ_0000144/miR (show MLXIP Proteins)-217 network. These results revealed the oncogenic role of RUNX2 in bladder neoplasm.

  2. In summary, these results reveal that PTHLH expression is a poor prognosis marker in head and neck squamous cell carcinoma patients, and RUNX2-PTHLH axis contributes to head and neck squamous cell carcinoma tumor growth.

  3. Knockdown of RUNX2 significantly inhibited TE-1 and EC-109 cell viability, repressed TE-1 cell migration and invasion, and increased TE-1 cell apoptosis and were associated with the activation of the PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) and ERK (show EPHB2 Proteins) pathways.

  4. Results show that RUNX2 gene silencing increased gemcitabine (GEM (show GEM Proteins)) sensitivity of p53mutated pancreatic cancer (PaCa) MiaPaCa2 spheres suggesting that RUNX2 is involved in PaCa-GEM (show GEM Proteins) resistance in presence of mutated p53 (show TP53 Proteins).

  5. Runx2 overexpression effectively decreased TNF-alpha (show TNF Proteins)-induced Bax (show BAX Proteins) and cleaved caspase-3 (show CASP3 Proteins) expression levels

  6. RUNX2 is one of the promising molecular targets for the treatment of the patients with pancreatic cancer regardless of their p53 (show TP53 Proteins) status[review]

  7. we identified a novel missense mutation of RUNX2 in 2 patients by Whole exome sequencing and showed potential correlations between facial phenotypes and missense mutations in Runt (show RUNX1 Proteins) domain through a mini-meta analysis.

  8. Mutant Runx2 regulates amelogenesis and osteogenesis through a miR-185-5p-Dlx2 axis.

  9. Results show that RUNX2 is highly expressed in bladder cancer tissues and are negatively correlated with miR (show MLXIP Proteins)-154 levels. This is likely through miR (show MLXIP Proteins)-154 binding the 3'-UTR of RUNX2 mRNA, promoting its degradation.

  10. Results identified a novel mutation besides the previously known in one patient with cleidocranial dysplasia (CCD). G462X mutation in exon 8 is located in the C-terminus of proline/serine/threonine-rich (PST (show SULT1A1 Proteins)) domain. It might reduce the Runx2 transacting activity, lower the protein stability, downgrade the expression of bone marker genes, and eventually diminish osteoblast differentiation in CCD patients.

Zebrafish Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. Runx2 may have an evolutionarily conserved role in axis formation

Mouse (Murine) Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. This study reveals that RUNX2 is differentially expressed in ATII cells vs. fibroblasts in lung fibrosis, which contributes to profibrotic cell function. Cell-specific targeting of RUNX2 pathways may represent a therapeutic approach for IPF.

  2. we have identified novel interaction between p38 MAPK (show MAPK14 Proteins) and Runx2 enhances Runx2 transactivity, thus promoting vascular smooth muscle cells calcification

  3. By using microRNA array, we identified a large number of microRNAs that showed different expression between wild-type Runx2 group and mutant groups. The aim of this study is to find out the effect of mmu-miR (show MLXIP Proteins)-1963, which was downregulated in all mutant Runx2 groups, on the ameloblast differentiation of LS8 cells

  4. Results indicate that Dlx5 (show DLX5 Proteins) and Runx2 are critical factors for the upregulated Osterix (show SP7 Proteins) expression in shPP2A cells, which is considered to be important for the accelerated osteoblast differentiation in these cells.

  5. the expression of mouse Amtn gene in amelogenesis is mediated by Runx2/Cbfbeta complex. Runx2/Cbfbeta can bind to the two Runx2 binding motifs AACCACT (-1342/-1336) and AACCAAA (-98/-92) in the Amtn promoter and regulate Amtn gene expression.

  6. Mutant Runx2 regulates amelogenesis and osteogenesis through a miR-185-5p-Dlx2 axis.

  7. Puerarin may promote MC3T3E1 osteoblastlike cell viability and differentiation, which may be related to the downregulation of miR204 and the following activation of Runx2.

  8. mTOR (show FRAP1 Proteins)/Raptor (show RPTOR Proteins) signaling is essential for bone formation in vivo through the regulation of Runx2 expression.

  9. these findings provide evidence that Cx43 (show GJA1 Proteins) and Runx2 functionally intersect in vivo to regulate cortical bone properties and affect osteoblast differentiation and proliferation

  10. miR (show MLXIP Proteins)-133a-5p targets the 3' UTR of RUNX2 mRNA to regulate the expression of RUNX2 negatively.

Rabbit Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. The results suggest that gene therapy using Runx2-modi fi ed dental pulp stem cells was more effective during bone deposition and new bone formation in tibia Distraction osteogenesis.

  2. Runx2-modified adipose-derived stem cells promote tendon graft integration in anterior cruciate ligament reconstruction.

  3. The OPG (show TNFSF11 Proteins) expression levels decreased while those of RANKL (show TNFSF11 Proteins) and RUNX2 increased during orthodontic tooth movement, which suggested that they play a role in the osteogenesis process and the reconstruction of periodontal tissue.

Xenopus laevis Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. These data also indicate that MGP (show MGP Proteins) is under dual regulation by runx2 through the use of various isoforms and context-dependent formation of transcriptional complexes.

Pig (Porcine) Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. Klotho (show KL Proteins) gene deficiency promotes high-fat diet-induced fibrosis in aortic valves, likely through the AMPKalpha (show GRK4 Proteins)-RUNX2 pathway.

RUNX2 Protein Profile

Protein Summary

This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.

Gene names and symbols associated with RUNX2

  • runt related transcription factor 2 (RUNX2)
  • runt-related transcription factor 2a (runx2a)
  • runt related transcription factor 2 (Runx2)
  • runt-related transcription factor 2 (Runx2)
  • runt related transcription factor 2 (runx2)
  • runt-related transcription factor 2 (LOC703331)
  • runt-related transcription factor 2 (LOC100549663)
  • runt related transcription factor 2 L homeolog (runx2.L)
  • runt-related transcription factor 2 (RUNX2)
  • aml3 protein
  • Cbf protein
  • CBF-alpha-1 protein
  • Cbfa-1 protein
  • cbfa1 protein
  • ccd protein
  • ccd1 protein
  • CLCD protein
  • LS3 protein
  • OSF-2 protein
  • osf2 protein
  • pea2aa protein
  • pebp2a1 protein
  • pebp2a2 protein
  • pebp2aa protein
  • pebp2aa1 protein
  • Pebpa2a protein
  • RUNX2 protein

Protein level used designations for RUNX2

PEA2-alpha A , PEBP2-alpha A , SL3-3 enhancer factor 1 alpha A subunit , SL3/AKV core-binding factor alpha A subunit , acute myeloid leukemia 3 protein , core-binding factor, runt domain, alpha subunit 1 , oncogene AML-3 , osteoblast-specific transcription factor 2 , polyomavirus enhancer-binding protein 2 alpha A subunit , runt-related transcription factor 2 , transcription factor Runx2a , AKV core binding factor , CBF-alpha-1 , PEBP2 alpha A , core binding factor alpha 1 , runt domain, alpha subunit 1 , core-binding factor subunit alpha-1 , runt related transcription factor 2 , transcription factor Cbfa1 , runt-related factor 2 , core binding factor alpha 1 subunit , runt-related transcription factor 2-like , Runx2 spliced isoform , runt-related transcription factor 2 type I , runt-related transcription factor 2 type II

GENE ID SPECIES
860 Homo sapiens
405784 Danio rerio
12393 Mus musculus
367218 Rattus norvegicus
373919 Gallus gallus
445986 Takifugu rubripes
472017 Pan troglodytes
703331 Macaca mulatta
100008943 Oryctolagus cuniculus
100033890 Equus caballus
100080409 Ornithorhynchus anatinus
100189546 Xenopus (Silurana) tropicalis
100222668 Taeniopygia guttata
100406564 Callithrix jacchus
100453201 Pongo abelii
100549663 Meleagris gallopavo
100555776 Anolis carolinensis
100619969 Monodelphis domestica
100037059 Xenopus laevis
536911 Bos taurus
100737965 Sus scrofa
474923 Canis lupus familiaris
100734175 Cavia porcellus
100861217 Capra hircus
101115489 Ovis aries
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