Runt-Related Transcription Factor 2 Proteins (RUNX2)

RUNX2 is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. Additionally we are shipping RUNX2 Antibodies (239) and RUNX2 Kits (52) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RUNX2 860 Q13950
RUNX2 12393 Q08775
RUNX2 367218  
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Top RUNX2 Proteins at antibodies-online.com

Showing 10 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$8,498.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$8,498.50
Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
$746.00
Details
Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 15 to 18 Days
$784.00
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Log in to see 10 to 12 Days
$251.74
Details
Yeast Horse His tag   1 mg Log in to see 60 to 71 Days
$2,271.50
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,541.00
Details
Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days
$668.03
Details
Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 11 to 18 Days
$696.46
Details

RUNX2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine) ,

Rat (Rattus)

More Proteins for Runt-Related Transcription Factor 2 (RUNX2) Interaction Partners

Human Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. These findings suggest possible involvement of RUNX2-rs194328 in the etiology of NS-CL+/-P in Korean cleft-parent trios without excess parental transmission.

  2. WWOX (show WWOX Proteins) expression was strongly inhibited in human lung cancers and lung cancer cell lines. Reintroducing WWOX (show WWOX Proteins) into lung cancer cells inhibited their invasive phenotype through downregulating RUNX2 and its target genes including MMP-9 (show MMP9 Proteins) expression.

  3. our results strongly suggest that RUNX2 might be a key player in receptor tyrosine kinase (show RET Proteins) (RTK)-based autocrine loops and a mediator of resistance to BRAF (show BRAF Proteins) V600E inhibitors involving RTK up regulation in melanoma.

  4. Thus, WNT (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) activation is required for RUNX2 expression in at least some osteosarcoma cell types, where RUNX2 is known to promote expression of metastasis related genes.

  5. miR (show MLXIP Proteins)-105/Runx2 axis mediates FGF2 (show FGF2 Proteins)-induced ADAMTS (show ADAMTS13 Proteins) expression in osteoarthritis cartilage.

  6. regulation of gal-3 (show LGALS3 Proteins) expression was strongly correlated with runx2 transcription factor in human thyroid carcinoma.

  7. Studied association of runt-related transcription factor 2 (RUNX2) polymorphisms with susceptibility and prognosis of ossification of posterior longitudinal ligament.

  8. these studies define a novel fibrinogen-alpha9beta1-SMAD1 (show GARS Proteins)/5/8-RUNX2 signaling axis can efficiently induce osteogenic differentiation from human embryonic stem cells and induced pluripotent stem cells.

  9. Data show that BRD4 (show BRD4 Proteins) controls RUNX2 by binding to the enhancers (ENHs) and each RUNX2 ENH (show PDLIM5 Proteins) is potentially controlled by a distinct set of TFs and c-JUN (show JUN Proteins) as the principal pivot of this regulatory platform.

  10. TGF-beta1 (show TGFB1 Proteins) stimulates the phosphorylation of Runx2 at three serine amino acids, and this event is required for MMP-13 (show MMP13 Proteins) expression in osteoblastic cells.

Zebrafish Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. Runx2 may have an evolutionarily conserved role in axis formation

Mouse (Murine) Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. results suggest that Edil3 may stimulate osteoblast differentiation and matrix mineralization by increasing expression of Runx2 through alpha5beta1 integrin /ERK (show EPHB2 Proteins) pathway

  2. Taken together, these results demonstrate that piperine enhance osteoblast differentiation through AMPK (show PRKAA1 Proteins) phosphorylation in MC3T3-E1 cells.

  3. Sphingosine 1 phosphate also up-regulated runt-related transcription factor 2 (Runx2) expression through S1PR2 (show S1PR2 Proteins)/RhoA (show RHOA Proteins)/ROCK/Smad1 (show SMAD1 Proteins)/5/8 signaling.

  4. Nearly half of all DNase (show DNASE2 Proteins) hypersensitivity sites (both constitutive and dynamic) overlap binding events of the bone-essential RUNX2 and/or the chromatin-related CTCF (show CTCF Proteins) transcription factors.

  5. The findings suggest that the absence of uPA (show PLAU Proteins) correlates with increased levels of Runx transcriptional regulators in a way that promotes inflammation-associated carcinogenesis.

  6. Fam50a (show FAM50A Proteins) might be a new positive regulator of ameloblast differentiation, increasing binding affinity of Runx2 to Ambn (show AMBN Proteins) promoter by physically interacting with Runx2.

  7. Knockdown of MACF1 (show MACF1 Proteins) in osteoblastic cells inhibits osteoblast differentiation through suppressing the beta-catenin (show CTNNB1 Proteins)/TCF1 (show HNF1A Proteins)-Runx2 axis.

  8. These results suggest that Dietary methionine restriction (MR) alters bone remodeling and apposition. In MR mice, miR (show MLXIP Proteins)-31 in plasma and liver, and miR (show MLXIP Proteins)-133a, miR (show MLXIP Proteins)-335-5p, and miR (show MLXIP Proteins)-204 in the bone marrow was elevated. These miRNAs were shown previously to target and regulate Osterix (show SP7 Proteins) and RUNX2 in bone, which could inhibit osteoblast differentiation and function.

  9. SIRT1 (show SIRT1 Proteins) interacts with and promotes the transactivation potential of RUNX2.

  10. ABL (show ABL1 Proteins) potentiated the assembly and activation of the RUNX2-TAZ (show TAZ Proteins) master transcription factor complex that is required for osteoblastogenesis, while antagonizing PPARgamma (show PPARG Proteins)-mediated adipogenesis.

Rabbit Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. The results suggest that gene therapy using Runx2-modi fi ed dental pulp stem cells was more effective during bone deposition and new bone formation in tibia Distraction osteogenesis.

  2. Runx2-modified adipose-derived stem cells promote tendon graft integration in anterior cruciate ligament reconstruction.

  3. The OPG (show TNFSF11 Proteins) expression levels decreased while those of RANKL (show TNFSF11 Proteins) and RUNX2 increased during orthodontic tooth movement, which suggested that they play a role in the osteogenesis process and the reconstruction of periodontal tissue.

Xenopus laevis Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. These data also indicate that MGP (show MGP Proteins) is under dual regulation by runx2 through the use of various isoforms and context-dependent formation of transcriptional complexes.

Pig (Porcine) Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. Klotho (show KL Proteins) gene deficiency promotes high-fat diet-induced fibrosis in aortic valves, likely through the AMPKalpha (show GRK4 Proteins)-RUNX2 pathway.

RUNX2 Protein Profile

Protein Summary

This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.

Gene names and symbols associated with RUNX2

  • runt related transcription factor 2 (RUNX2)
  • runt-related transcription factor 2a (runx2a)
  • runt related transcription factor 2 (Runx2)
  • runt-related transcription factor 2 (Runx2)
  • runt related transcription factor 2 (runx2)
  • uncharacterized LOC449531 (LOC449531)
  • runt-related transcription factor 2 (LOC703331)
  • runt-related transcription factor 2 (LOC100549663)
  • runt related transcription factor 2 L homeolog (runx2.L)
  • runt-related transcription factor 2 (RUNX2)
  • aml3 protein
  • Cbf protein
  • CBF-alpha-1 protein
  • Cbfa-1 protein
  • cbfa1 protein
  • ccd protein
  • ccd1 protein
  • CLCD protein
  • LS3 protein
  • OSF-2 protein
  • osf2 protein
  • pea2aa protein
  • pebp2a1 protein
  • pebp2a2 protein
  • pebp2aa protein
  • pebp2aa1 protein
  • Pebpa2a protein
  • RUNX2 protein

Protein level used designations for RUNX2

PEA2-alpha A , PEBP2-alpha A , SL3-3 enhancer factor 1 alpha A subunit , SL3/AKV core-binding factor alpha A subunit , acute myeloid leukemia 3 protein , core-binding factor, runt domain, alpha subunit 1 , oncogene AML-3 , osteoblast-specific transcription factor 2 , polyomavirus enhancer-binding protein 2 alpha A subunit , runt-related transcription factor 2 , transcription factor Runx2a , AKV core binding factor , CBF-alpha-1 , PEBP2 alpha A , core binding factor alpha 1 , runt domain, alpha subunit 1 , core-binding factor subunit alpha-1 , runt related transcription factor 2 , transcription factor Cbfa1 , runt-related factor 2 , core binding factor alpha 1 subunit , runt-related transcription factor 2-like , Runx2 spliced isoform , runt-related transcription factor 2 type I , runt-related transcription factor 2 type II

GENE ID SPECIES
860 Homo sapiens
405784 Danio rerio
12393 Mus musculus
367218 Rattus norvegicus
373919 Gallus gallus
445986 Takifugu rubripes
449531 Canis lupus familiaris
472017 Pan troglodytes
703331 Macaca mulatta
100008943 Oryctolagus cuniculus
100033890 Equus caballus
100080409 Ornithorhynchus anatinus
100189546 Xenopus (Silurana) tropicalis
100222668 Taeniopygia guttata
100406564 Callithrix jacchus
100453201 Pongo abelii
100549663 Meleagris gallopavo
100555776 Anolis carolinensis
100619969 Monodelphis domestica
100037059 Xenopus laevis
536911 Bos taurus
100737965 Sus scrofa
474923 Canis lupus familiaris
100734175 Cavia porcellus
100861217 Capra hircus
101115489 Ovis aries
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