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RUNX2 Products

(Runt-Related Transcription Factor 2 (RUNX2))

Categories

This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Jul 2008].

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Featured RUNX2 Categories

RUNX2 Antibodies

High quality antibodies with extensive validation data.

RUNX2 ELISA Kits

Reliable ELISA kits for a wide range of species.

RUNX2 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended RUNX2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application IF, IHC (p), ELISA, WB
Validations
  • (5)
  • (7)
Cat. No. ABIN514045
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application IF, IHC (p), ELISA, WB
Validations
  • (2)
  • (9)
Cat. No. ABIN560185
Quantity 100 μg
Datasheet Datasheet
Reactivity Cow, Guinea Pig, Horse, Human, Mouse, Rat, Zebrafish (Danio rerio)
Application WB
Validations
  • (2)
  • (5)
Cat. No. ABIN2780588
Quantity 100 μL
Datasheet Datasheet

Recommended RUNX2 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (2)
  • (1)
Cat. No. ABIN6959206
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (5)
  • (1)
Cat. No. ABIN6959207
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6969976
Quantity 96 tests
Datasheet Datasheet

Recommended RUNX2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3134872
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1318998
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1319000
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our RUNX2 products

Yu, Zheng, Li, Lin, Chen, Tian, Chen, Zhang, Xu, Shen: "The Toll-like receptor ligand, CpG oligodeoxynucleotides, regulate proliferation and osteogenic differentiation of osteoblast." in: Journal of orthopaedic surgery and research, Vol. 15, Issue 1, pp. 327, (2021) (PubMed).

Priante, Ceol, Gianesello, Furlan, Del Prete, Anglani: "Human proximal tubular cells can form calcium phosphate deposits in osteogenic culture: role of cell death and osteoblast-like transdifferentiation." in: Cell death discovery, Vol. 5, pp. 57, (2019) (PubMed).

Mizuhashi, Nagata, Matsushita, Ono, Ono: "Growth Plate Borderline Chondrocytes Behave as Transient Mesenchymal Precursor Cells." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, (2019) (PubMed).

Herreño, Ramírez, Chaparro, Fernandez, Cañas, Morantes, Moreno, Brugés, Mejía, Bustos, Montecino, Rojas: "Role of RUNX2 transcription factor in epithelial mesenchymal transition in non-small cell lung cancer lung cancer: Epigenetic control of the RUNX2 P1 promoter." in: Tumour biology, Vol. 41, Issue 5, pp. 1010428319851014, (2019) (PubMed).

Qu, Li, Jin, Zhang, He: "Silent Mating Type Information Regulation 2 Homolog (SIRT1) Influences Osteogenic Proliferation and Differentiation of MC3T3-E1 Cells via Regulation of miR-132-3p." in: Medical science monitor : international medical journal of experimental and clinical research, Vol. 25, pp. 2289-2295, (2019) (PubMed).

Darrieutort-Laffite, Arnolfo, Garraud, Adrait, Couté, Louarn, Trichet, Layrolle, Le Goff, Blanchard: "Rotator Cuff Tenocytes Differentiate into Hypertrophic Chondrocyte-Like Cells to Produce Calcium Deposits in an Alkaline Phosphatase-Dependent Manner." in: Journal of clinical medicine, Vol. 8, Issue 10, (2019) (PubMed).

Sharma, Sharma, Maheshwari, Pachori, Kumari, Mandal: "Docosahexaenoic Acid (DHA) Inhibits Bone Morphogenetic Protein-2 (BMP-2) Elevated Osteoblast Potential of Metastatic Breast Cancer (MDA-MB-231) Cells in Mammary Microcalcification." in: Nutrition and cancer, pp. 1-11, (2019) (PubMed).

Thrivikraman, Athirasala, Gordon, Zhang, Bergan, Keene, Jones, Xie, Chen, Tao, Wingender, Gower, Ferracane, Bertassoni: "Rapid fabrication of vascularized and innervated cell-laden bone models with biomimetic intrafibrillar collagen mineralization." in: Nature communications, Vol. 10, Issue 1, pp. 3520, (2019) (PubMed).

Wu, Ou, Wang, Yang, Wang, Liu, Xiong, Sun, Zhang, Zhu: "Icaritin induces MC3T3-E1 subclone14 cell differentiation through estrogen receptor-mediated ERK1/2 and p38 signaling activation." in: Biomedicine & pharmacotherapy, Vol. 94, pp. 1-9, (2018) (PubMed).

Zhang, Wang, Zeng, Yan, Ouyang, Liu, Sun, Zhao, Fang, Pan, Xie, Yang, Zhang, Bai, Cai: "mTORC1 activation downregulates FGFR3 and PTH/PTHrP receptor in articular chondrocytes to initiate osteoarthritis." in: Osteoarthritis and cartilage, Vol. 25, Issue 6, pp. 952-963, (2018) (PubMed).

Synonyms and alternative names related to RUNX2

runt related transcription factor 2 (RUNX2), runt-related transcription factor 2a (runx2a), runt related transcription factor 2 (Runx2), runt-related transcription factor 2 (Runx2), runt related transcription factor 2 (runx2), runt-related transcription factor 2 (LOC703331), runt-related transcription factor 2 (LOC100549663), runt related transcription factor 2 L homeolog (runx2.L), runt-related transcription factor 2 (RUNX2), AML3, aml3, Cbf, CBF-alpha-1, Cbfa-1, CBFA1, Cbfa1, cbfa1, CCD, ccd, CCD1, ccd1, CLCD, LS3, OSF-2, OSF2, Osf2, osf2, PEA2aA, pea2aa, Pebp2a1, pebp2a1, pebp2a2, PEBP2aA, pebp2aa, pebp2aa1, Pebpa2a, runx2, RUNX2

Protein level used designations for RUNX2

  • PEA2-alpha A
  • PEBP2-alpha A
  • SL3-3 enhancer factor 1 alpha A subunit
  • SL3/AKV core-binding factor alpha A subunit
  • acute myeloid leukemia 3 protein
  • core-binding factor, runt domain, alpha subunit 1
  • oncogene AML-3
  • osteoblast-specific transcription factor 2
  • polyomavirus enhancer-binding protein 2 alpha A subunit
  • runt-related transcription factor 2
  • transcription factor Runx2a
  • AKV core binding factor
  • CBF-alpha-1
  • PEBP2 alpha A
  • core binding factor alpha 1
  • runt domain, alpha subunit 1
  • core-binding factor subunit alpha-1
  • runt related transcription factor 2
  • transcription factor Cbfa1
  • runt-related factor 2
  • core binding factor alpha 1 subunit
  • runt-related transcription factor 2-like
  • Runx2 spliced isoform
  • runt-related transcription factor 2 type I
  • runt-related transcription factor 2 type II
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