Runt-Related Transcription Factor 3 (RUNX3) ELISA Kits

RUNX3 encodes a member of the runt domain-containing family of transcription factors. Additionally we are shipping RUNX3 Antibodies (140) and RUNX3 Proteins (12) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
RUNX3 12399  
RUNX3 864 Q13761
RUNX3 156726  
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Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
Human 0.054 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests 13 to 16 Days
  96 Tests 2 to 3 Days

More ELISA Kits for RUNX3 Interaction Partners

Zebrafish Runt-Related Transcription Factor 3 (RUNX3) interaction partners

  1. In neuronal fate determination, Runx co-factor Cbfbeta is essential for its function, but the high level of Runx3 expression can overcome the loss of Cbfbeta, demonstrating that Cbfbeta in this context serves solely as a signal amplifier of Runx3 activity.

  2. successive induction of the transcription factors Runx3, Egr1 and Sox9b constitutes a regulatory cascade that controls expression of Follistatin A in pharyngeal endoderm, the latter modulating BMP signaling in developing cranial cartilage in zebrafish

  3. isolation and characterization by spatiotemporal expression detected in the developing zebrafish

  4. Runx3 expression leads to an increase in primitive blood cell numbers, together with an increase in runx1-expressing cells in the ventral wall of the dorsal aorta.

  5. Zebrafish embryos lacking Rad21, or cohesin subunit Smc3, fail to express runx3 and lose hematopoietic runx1 expression in early embryonic development.

Pig (Porcine) Runt-Related Transcription Factor 3 (RUNX3) interaction partners

  1. These results demonstrate that the CRISPR/Cas9 system is effective in inducing mutations on a specific locus of genome and the RUNX3 knockout pigs can be useful resources for human cancer research and to develop novel cancer therapies.

Mouse (Murine) Runt-Related Transcription Factor 3 (RUNX3) interaction partners

  1. Runx3 influences group 1 ILC- and NCR+ILC3-mediated immune protection against intracellular bacterial infections of both the gut and liver.

  2. Study using Runx3 heterozygous mice hindlimb ischemic model and Lewis lung carcinoma cell allograft model revealed that Runx3 inhibits vasculogenesis via the inhibition of endothelial progenitor cells differentiation and function via the suppression of Hif1alpha activity.

  3. unx3 plays a key role in female reproduction by regulating folliculogenesis and steroidogenesis in granulosa cells.

  4. Runx3 governs chromatin accessibility during T cell receptor stimulation and enforces the memory cytotoxic T lymphocyte developmental program.

  5. The promoter regions of Runx3 is targets of STAT4 and that STAT4 binding during NK cell activation induces epigenetic modifications of Runx3 gene loci resulting in increased expression.

  6. Runx3 programs CD8(+) T cell residency in non-lymphoid tissues and tumours; results provide insight into the signals that promote T cell residency in non-lymphoid sites, which could be used to enhance vaccine efficacy or adoptive cell therapy treatments that target cancer

  7. Findings suggest that Runx3 may regulate cell shape to inhibit melanoma cell migration partly through enhancing stress fiber formation and ECM protein production.

  8. The findings suggest that the absence of uPA correlates with increased levels of Runx transcriptional regulators in a way that promotes inflammation-associated carcinogenesis.

  9. Runx3-deficient CD8(+) cytotoxic effector T cells aberrantly upregulated genes characteristic of follicular helper T (TFH) cell lineage, including Bcl6, Tcf7 and Cxcr5. Mechanistically, the Runx3-CBFbeta transcription factor complex deployed H3K27me3 to Bcl6 and Tcf7 genes to suppress the TFH program.

  10. Deletion of Runx3 in the peripheral nervous system or specifically in peripheral sensory neurons, or of enhancer elements driving Runx3 expression in proprioceptive neurons, induced prepubertal scoliosis.

  11. We found that Runx3 exerted a positive effect on early myeloid development

  12. Runx3 plays a crucial role in the hypothalamo-pituitary-gonadal axis

  13. intricate combinatorial interplay among the three regulatory elements governs Runx3 expression in distinct subtypes of TrkC neurons while concomitantly extinguishing its expression in non-TrkC neurons

  14. this study identifies a compensatory signaling mechanism that prevents lineage-fate errors by dynamically modulating Runx3d induction rates during MHC I positive selection

  15. our data suggest that Runx3 may play a crucial role in the development of DRGs by regulating the expression of Ntrk3 variants

  16. Runx3 is crucial for the phenotypic and functional changes observed in ThPok-deficient invariant natural killer T cells.

  17. the transcription factor Runx3 was essential for the normal development of subsets of innate lymphoid cells (ILCs) in the mucosa

  18. Runx1 and Runx3 are the downstream effectors of Nanog, especially in the early and intermediate osteogenic differentiation of the mouse mesenchymal cell line C3H10T1/2.

  19. nonpermissive expression of RUNX3 protein is restricted at the translational level, and that the repression is further enforced by a transcriptional regulation for maintenance of diverse developmental plasticity of T cells for different effector subsets.

  20. Our findings establish Nr4a1 as a novel and critical player in the regulation of CD8 T cell development through the direct suppression of Runx3.

Human Runt-Related Transcription Factor 3 (RUNX3) interaction partners

  1. miR-148-3p directly repressed the expression of DNMT1 and inhibited proliferation, migration, and invasion by regulating DNMT1-RUNX3 axis and the epithelial-mesenchymal transition in glioblastoma multiforme (GBM). Our findings provide a new foundation for treatment of patients with GBM.

  2. RUNX3 methylation level is negatively associated with overall survival in clear cell renal cell carcinoma.

  3. Three SNPs (RUNX3 rs7553295 G > T, AMD1 rs1279590 G > A and MSRA rs73534533 C > A) were replicated in the validation dataset, and their meta-analysis showed an adjusted hazards ratio [HR] of 0.82 [95% confidence interval (CI) =0.75-0.89] and pmeta = 2.86 x 10(-6) , 0.81 (0.73-0.91) and pmeta = 4.63 x 10(-4) , and 0.77 (0.68-0.89) and pmeta = 2.07 x 10(-4) , respectively).

  4. A direct role for RUNX3 in TRAIL-induced apoptosis via activation of DR5 in colorectal cancer.RUNX3 induces reactive oxygen species generation via transcriptional inhibition of SOD3.

  5. RUNX1/RUNX3 poly(ADP-Ribosyl)ation and BLM interaction facilitate the Fanconi anemia pathway of DNA repair.

  6. Measurement of RUNX3 gene expression in peripheral blood mononuclear cells has a certain value in identifying children with atopic constitution at high risk of asthma among children with bronchiolitis

  7. miR-210 released from adipose-derived stem cell-derived microvesicle promoted proliferation, migration and invasion of human umbilical vein endothelial cells by targeting RUNX3.

  8. In summary, these data suggest that hypermethylation of the RUNX3 gene promoter may play an important role in estrogen receptor-positive breast tumor progression.

  9. REVIEW: immunomodulatory functions of RUNX3 within the hematopoietic compartment to gain insight into the consequences of Runx3 deletion or overexpression in committed immune cells

  10. In vitro, prolonged activation of naive CD4 T cells in presence of Th1 polarizing cytokines led to the acquisition of perforin-dependent cytotoxic activity. This process was dependent on the Th1 transcription factor Runx3 and was limited by the sustained expression of ThPOK.

  11. 17 Single Nucleotide Polymorphisms in ERAP1/ERAP2 and RUNX3 genes did not confer disease susceptibility to ankylosing spondylitis in Chinese Han.

  12. Cytoplasmic mislocalization of RUNX3 protein may be a common event in tongue SCC.

  13. RUNX3 regulates cell cycle-dependent chromatin dynamics by functioning as a pioneer factor of the cell cycle restriction point.

  14. HP plays an important role in the development and progression of GC through silencing of CDH1, RUNX3, p21WAF and p27 expression

  15. The present study suggested a genetic association between RUNX3 gene polymorphisms and severe preeclampsia

  16. The Runx3 may regulate the development of T cell lineage including those of innate lymphoid cells, Treg cells and dendritic cells, which may contribute to the development of hypersensitivity and asthma.

  17. Runx3 ubiquitination is regulated by HOTAIR in the gastric cancer.HOTAIR is negatively associated with Runx3 in gastric cancer tissues.

  18. RUNX3 creates an effective barrier against further TGFbeta-dependent tumor progression by preventing genomic instability.

  19. Therefore miR199b may serve as an oncogene in Wilms' tumour (WT)progression by directly targeting RUNX3, thereby suggesting that the miR199b/RUNX3 axis may be a promising therapeutic target for patients with WT

  20. High expression of miR-20a-5p significantly decreased both the mRNA and protein levels of RUNX3, as well as its direct downstream targets Bim and p21.

RUNX3 Antigen Profile

Antigen Summary

This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with RUNX3

  • runt-related transcription factor 3 (runx3) antibody
  • runt-related transcription factor 3 (RUNX3) antibody
  • runt related transcription factor 3 (RUNX3) antibody
  • runt related transcription factor 3 (runx3) antibody
  • runt related transcription factor 3 L homeolog (runx3.L) antibody
  • runt related transcription factor 3 (Runx3) antibody
  • runt-related transcription factor 3 (Runx3) antibody
  • AML2 antibody
  • Cbfa3 antibody
  • frrunx3 antibody
  • Pebp2a3 antibody
  • PEBP2aC antibody
  • runx3 antibody
  • runxb antibody

Protein level used designations for RUNX3

runt-related transcription factor b , runt-related transcription factor 3 , core-binding factor 3 , frRunx3/p45 , CBF-alpha-3 , PEA2-alpha C , PEBP2-alpha C , SL3-3 enhancer factor 1 alpha C subunit , SL3/AKV core-binding factor alpha C subunit , acute myeloid leukemia 2 protein , core binding factor alpha 3 , core-binding factor subunit alpha-3 , oncogene AML-2 , polyomavirus enhancer-binding protein 2 alpha C subunit , runt domain, alpha subunit 3 , transcription factor AML2/CBFA3 , PEA2 alpha C , PEBP2 alpha C , acute myeloid leukemia gene 2 , core-binding factor, runt domain, alpha subunit 3 , transcription factor AML2 , Runt related transcription factor 3 , Runx3 MASN-variant

58127 Danio rerio
403159 Sus scrofa
456633 Pan troglodytes
100049632 Takifugu rubripes
100474431 Ailuropoda melanoleuca
100500732 Xenopus laevis
12399 Mus musculus
864 Homo sapiens
617389 Bos taurus
156726 Rattus norvegicus
769687 Gallus gallus
487366 Canis lupus familiaris
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