SAM Domain and HD Domain 1 Proteins (SAMHD1)

SAMHD1 may play a role in regulation of the innate immune response. Additionally we are shipping SAMHD1 Antibodies (165) and SAMHD1 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SAMHD1 25939 Q9Y3Z3
SAMHD1 56045 Q60710
Rat SAMHD1 SAMHD1 311580  
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Top SAMHD1 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$547.80
Details

SAMHD1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for SAM Domain and HD Domain 1 (SAMHD1) Interaction Partners

Human SAM Domain and HD Domain 1 (SAMHD1) interaction partners

  1. Multiple domains of SAMHD1(e.g., N-terminus, nuclear localization signal, linker, HD domain, and C-terminus)are essential for Vpx-induced degradation.[review]

  2. findings indicate a novel role for SAMHD1 in regulating HIV-1 latency, which enhances our understanding of the mechanisms regulating proviral gene expression in CD4 (show CD4 Proteins)(+) T cells.

  3. results demonstrate that the interaction of CD81 (show CD81 Proteins) with SAMHD1 controls the metabolic rate of HIV-1 replication by tuning the availability of building blocks for reverse transcription, namely dNTPs

  4. Immune activation during HIV-1 infection influences SAMHD1 expression and degradation.

  5. Studies of the phosphomimetic and tetramerization-defective mutants of SAMHD1 reveal poor correlation between tetramerization propensity and dNTPase activity observed in vitro and the ability of the proteins to deplete cellular dNTPs and to restrict retroviral restriction. These results suggest that enzymatic activity of SAMHD1 may be subject to additional cellular regulatory mechanisms that have not yet been elucidated.

  6. Upregulation of endogenous SAMHD1 expression is attributed to the phosphorylation and nuclear translocation of IRF3 (show IRF3 Proteins).

  7. Findings define a dNTPase-independent function for SAMHD1 in HR-mediated DSB repair by facilitating CtIP (show RBBP8 Proteins) accrual to promote DNA end resection, providing insight into how SAMHD1 promotes genome integrity.

  8. These results indicate that Vpx, in addition to SAMHD1, overcomes a previously unappreciated restriction for lentiviruses at the level of reverse transcription (RT)that acts independently of dNTP concentrations and is specific to resting CD4 (show CD4 Proteins) T cells.

  9. results indicate that the RXL motif is critical for tetramer formation, dNTPase activity, and HIV-1 restriction. These findings help us understand SAMHD1 interactions with other host proteins and the mechanisms regulating SAMHD1 structure and functions in cells.

  10. These results suggest that SAMHD1 is a relevant restriction factor for HBV and restricts reverse transcription through its dNTPase activity

Zebrafish SAM Domain and HD Domain 1 (SAMHD1) interaction partners

  1. Data suggest that zebrafish may represent a system for studying the relationship between type I interferon (show IFNA Proteins) (IFN) signaling and a loss of deoxynucleoside triphosphate triphosphohydrolase SAMHD1 activity.

Mouse (Murine) SAM Domain and HD Domain 1 (SAMHD1) interaction partners

  1. SAMHD1 crystal structure delineates the SAMHD1 allosteric activation process that governs SAMHD1 enzymatic activities.

  2. provide genetic evidence that cell-autonomous control of lentivirus infection in myeloid cells by SAMHD1 limits virus-induced production of interferons and the induction of co-stimulatory markers

  3. These data support a model in which SAMHD1 catalytic activity is regulated through tetramer stabilization by the carboxyl-terminal tail, phosphorylation destabilizing the complexes and inactivating the enzyme. ISF2 may serve to reduce the dNTP pool to very low levels as a means of restricting virus replication.

  4. These observations suggest that heterozygous cancer-associated SAMHD1 mutations increase mutation rates in cancer cells.

  5. SAMHD1 in the mouse blocks retroviral infection at the level of reverse transcription and is regulated through cell cycle-dependent phosphorylation.

  6. phosphorylation of mSAMHD1 at T634 by CDK1 (show CDK1 Proteins)/2 negatively regulates its HIV-1 restriction in differentiated cells, but does not affect its murine leukemia virus restriction in dividing cells.

  7. SAMHD1 restricts HIV-1 replication and regulates interferon (show IFNA Proteins) production in mouse myeloid cells.

  8. Allosteric regulation by dATP and dTTP works similarly in human and mouse SAMHD1.

  9. SAMHD1 decreases dNTP pool in murine cells, restricts retroviral replication and regulates type I IFN production.

  10. SAMHD1 can restrict lentiviruses in vivo and that nucleotide starvation is an evolutionarily conserved antiviral mechanism.

SAMHD1 Protein Profile

Protein Summary

This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome.

Gene names and symbols associated with SAMHD1

  • SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 (SAMHD1)
  • SAM domain and HD domain 1 (samhd1)
  • SAM domain and HD domain, 1 (Samhd1)
  • SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 (Samhd1)
  • CHBL2 protein
  • DCIP protein
  • E330031J07Rik protein
  • HDDC1 protein
  • Mg11 protein
  • MOP-5 protein
  • SBBI88 protein
  • si:dkeyp-44b8.8 protein

Protein level used designations for SAMHD1

SAM domain and HD domain-containing protein 1 , dNTPase , dendritic cell-derived IFNG-induced protein , deoxynucleoside triphosphate triphosphohydrolase SAMHD1 , monocyte protein 5 , SAM domain- and HD domain-containing protein 1 , IFN-gamma induced , interferon-gamma-inducible protein Mg11

GENE ID SPECIES
25939 Homo sapiens
524683 Bos taurus
419125 Gallus gallus
485862 Canis lupus familiaris
553453 Danio rerio
56045 Mus musculus
311580 Rattus norvegicus
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