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SEC14L2 encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. Additionally we are shipping SEC14-Like 2 (S. Cerevisiae) Antibodies (49) and many more products for this protein.
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Here, the authors report that the zebrafish/human phosphatidylinositol transfer protein (show PITPNA Proteins) Sec14l3 (show SEC14L3 Proteins)/SEC14L2 act as GTPase (show RACGAP1 Proteins) proteins to transduce Wnt (show WNT2 Proteins) signals from Frizzled to phospholipase C (PLC (show PLC Proteins)).
hTAP1 reduces the in vitro activity of the phosphatidylinositol-3-kinase gamma (PI3Kgamma (show PIK3CG Proteins)) indicating the formation of a stalled/inactive hTAP1/PI3Kgamma (show PIK3CG Proteins) heterodimer.
PI3Kgamma (show PIK3CG Proteins)-induced VEGF (show VEGFA Proteins) expression was reduced when the human tocopherol-associated protein 1 (hTAP1/SEC14L2) was overexpressed suggesting formation of an inactive PI3Kgamma (show PIK3CG Proteins)/hTAP1 heterodimer.
SEC14L2 enabled RNA replication of diverse HCV genotypes in several human hepatoma cell lines
novel association between the rs737723 polymorphism (SEC14L2/TAP) and higher primary open-angle glaucoma risk
TAP expression was significantly correlated with Her2/neu (show ERBB2 Proteins) receptor expression and breast cancer stage.
Discusses cloning of rat SEC14-like protein 3 (show SEC14L3 Proteins) and mentions three human SPF-related genes, known as SEC14-like protein 1 (show SEC14L1 Proteins), 2 and 3.
SPF has two domain topology, and the ligand binding cavity has a peculiar horseshoe-like shape
phosphorylation enhances its ability to stimulate microsomal squalene monooxygenase (show SQLE Proteins); phosphorylation may provide a means for the rapid short term modulation of cholesterol synthesis
Data report the three-dimensional crystal structure of human supernatant protein factor in complex with RRR (show RRS1 Proteins)-alpha-tocopherylquinone, the major physiological oxidation product of RRR (show RRS1 Proteins)-alpha-tocopherol, at a resolution of 1.95A.
This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene monooxygenase which is a downstream enzyme in the cholesterol biosynthetic pathway. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
SEC14-like protein 2
, alpha-tocopherol-associated protein
, squalene transfer protein
, supernatant protein factor
, tocopherol-associated protein
, SEC14-like 2