SERTA Domain Containing 1 (SERTAD1) ELISA Kits

Human SERTA Domain Containing 1 (SERTAD1) interaction partners

1. In human PCa tumor tissues, Sertad1 expression is positively correlated with AR expression and the Gleason score. Taken together, this report is the first to show that Sertad1 is a novel AR-LBD-binding protein, and DHT-liganded AR-LBD inhibits Sertad1 degradation.

2. Sertad1 could antagonize iASPP function by hindering its entrance into nuclei to interact with P53 in leukemic cells when iASPP was in the stage of overproduction.

3. Here, the authors show that transcriptional regulator interacting with the PHD-bromodomain 1 (TRIP-Br1, Sertad1), a newly identified protein with poorly characterized functions, acts as an adaptor that bridges the interaction of multiple Adenylyl cyclase isoforms with X-linked inhibitor of apoptosis protein (XIAP), a RING-domain E3 ubiquitin ligase.

4. NEDD4-1 recognizes SERTA domain containing proline rich region of p34SEI-1. Residues of NEDD4-1 responsible for direct interaction with p34SEI-1 are identified by NMR titration experiments.

5. SEI1 up-regulation induces genomic instability by inhibiting DNA damage response in ovarian cancer cells.

6. Findings provide evidence that TRIP-Br1 functions as an oncogenic protein by providing cancer cells resistance to the hypoxia-induced cell death of breast cancer cells.

7. TRIP-Br1 confers resistance to serum starvation-induced cell deaths by stabilizing the XIAP protein and inhibiting cellular ROS production.

8. Data demonstrate that p34SEI-1 induces the activation of either AKT or ILK signaling on HER2/neu expression status.

9. High SERTAD1 expression is associated with breast cancer.

10. These results suggest that p34 (SEI-1) inhibits ROS-induced cell death through by indirectly inducing ubiquitination of ASK1.

11. study shows that the p34SE1-1 expression level was not changed after H2O2 treatment at either protein or transcriptional levels

12. Translocation of small amount of NM23H1 into the nucleus induced by the overexpressions of SEI1/SET could increase the frequency of sister chromatid exchangein esophageal cancers.

13. p34SEI-1 strongly suppressed CREB-mediated transcription, and this suppression was overcome by excess amount of CBP

14. interacts with low- and high-risk HPV11 and HPV16 E6 proteins in yeast, in vitro and in mammalian cell cultures

15. p34SEI1 fragment 30-160 can bind, activate, and inhibit cyclin-dependent kinase CDK4; fragment 30-132 binds and activates but does not inhibit CDK4, while fragment 30-88 cannot bind, activate, or inhibit but retains LexA-mediated transactivation activity.

16. p34(SEI-1) and p16(INK4A) have different roles in development of squamous cell carcinoma of the head and neck

Mouse (Murine) SERTA Domain Containing 1 (SERTAD1) interaction partners

1. Sei-1 promotes double minute chromosomes formation with increasing passage number.

2. Met has a role in promoting formation of double minute chromosomes induced by Sei-1 in NIH-3T3 murine fibroblasts

3. these data suggest that SERTAD1 acts as a SMAD1 transcriptional co-activator to promote the expression of BMP target genes during mouse cardiogenesis.

4. Sertad1 expression is required is required for developmental neuronal death in the cerebral cortex.

5. conclude that Sei1 plays an important role in pancreatic beta-cells, which supports a functional link between Sei1 and the core cell cycle regulators specifically in the context of the pancreas