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Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins.
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MiR (show MLXIP Antibodies)-502 medaited histone methyltransferase SET8 expression is associated with outcome of esophageal squamous cell carcinoma.
these date elucidated that NT21MP and miR335 mediated PR of breast cancer cells partly through regulation of Wnt (show WNT2 Antibodies)/betacatenin signaling pathway. Activation of miR335 or inactivation of SETD8 could be a novel approach for the treatment of breast cancer.
High expression of SET8 is associated with cervical cancer.
This improves the binding of SAM (show TTN Antibodies), SAH (show ACSM3 Antibodies), and sinefungin by up to 10,000-fold. A small collection of inhibitors structurally related to SAM (show TTN Antibodies) were screened and 40 compounds were identified that only inhibit SETD8 when a nucleosome substrate is used
We demonstrated the expression levels of SET8 in TT genotype were higher than in CC genotypes, and high levels of SET8 were associated with poor survival in breast cancer
Lysine methylation represses p53 (show TP53 Antibodies) activity in teratocarcinoma cancer cells via up-regulation of SMYD2 (show SMYD2 Antibodies) and PR-Set7 and perpetuation of cancer cells proliferation.
The loss of SETD8 concurrently stimulated nucleolar function.
The PPARgamma (show PPARG Antibodies)-SETD8 axis constitutes an epigenetic, p53 (show TP53 Antibodies)-independent checkpoint on p21 (show CDKN1A Antibodies)-mediated cellular senescence.
miR (show MLXIP Antibodies)-502/SET8 regulatory circuit emerges as a key regulator of the pathobiology of breast cancer and a focal point for possible therapeutic intervention.
In non-small cell lung cancer cells, SETD8 expression suppression is involved in tumorigenesis and metastasis.
PR-Set7 is a direct target of Cul4A (show CUL4A Antibodies) for degradation and involved in the formation of lung tumors in the conditional Cul4A (show CUL4A Antibodies) transgenic mouse model.
These results suggest that Setd8 is an important regulator of erythroid maturation that works in part through repression of Gata2 (show GATA2 Antibodies) expression.
These results establish SetD8 as a determinant of erythroid cell maturation and provide a framework for understanding how a broadly expressed histone-modifying enzyme mediates cell-type-specific GATA factor function.
all of the H3K36-specific methyltransferases, including ASH1L (show ASH1L Antibodies), HYPB (show SETD2 Antibodies), NSD1 (show NSD1 Antibodies), and NSD2 (show WHSC1 Antibodies) were inhibited by ubH2A, whereas the other histone methyltransferases, including PRC2, G9a (show EHMT2 Antibodies), and Pr-Set7 were not affected by ubH2A.
Data indicate a vital link between GATA-1 (show GATA1 Antibodies) and the histone H4 (show HIST1H4H Antibodies) lysine 20 methyltransferase PR-Set7/SetD8 (SetD8).
Pr-set7 knockdown caused increased gammaH2AX (show H2AFX Antibodies) foci on chromosomes indicating DNA damage on chromosomes.
Setd8 is a crucial inhibitor of apoptosis in skin and its activity is essential for epidermal stem cell survival, proliferation and differentiation
the SET8 and PCNA (show PCNA Antibodies) interaction couples H4-K20 (show KRT20 Antibodies) methylation with DNA replication
PR-Set7 enzymatic activity is essential for mammalian cell cycle progression and for the maintenance of genomic stability, most likely by monomethylating histone H4K20.
Cell cycle analysis after synchronization indicated that defects at the S and G(2)/M phases were a consequence of decreased H4K20me1 due to the absence of PR-Set7.
Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes (By similarity).
, H4-K20-specific histone methyltransferase
, H4K20-specific histone methyltransferase splice variant Set8b
, N-lysine methyltransferase SETD8
, PR/SET domain containing protein 8
, PR/SET domain-containing protein 07
, SET domain-containing protein 8
, histone-lysine N-methyltransferase SETD8
, lysine N-methyltransferase 5A
, SET domain-containing 8