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SETD8 antibody (N-Term)

SETD8 Reactivity: Human, Mouse IF, IHC, ELISA, WB Host: Mouse Monoclonal 43AT551-86 unconjugated
Catalog No. ABIN3032551
$592.75
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  • Target See all SETD8 Antibodies
    SETD8 (SET Domain Containing (Lysine Methyltransferase) 8 (SETD8))
    Binding Specificity
    • 26
    • 9
    • 7
    • 7
    • 7
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 72
    • 23
    • 10
    Human, Mouse
    Host
    • 54
    • 18
    Mouse
    Clonality
    • 53
    • 19
    Monoclonal
    Conjugate
    • 30
    • 8
    • 6
    • 6
    • 6
    • 6
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SETD8 antibody is un-conjugated
    Application
    • 59
    • 43
    • 26
    • 9
    • 8
    • 6
    • 4
    • 3
    • 1
    • 1
    Immunofluorescence (IF), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
    Purification
    Purified
    Immunogen
    This SET07 antibody was raised using purified recombinant GST fusion protein encoding the N-terminal region of human SET07.
    Clone
    43AT551-86
    Isotype
    IgG1
  • Application Notes
    Titration of the SET07 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50,Immunofluorescence: 1:10-1:50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS pH 7.4 with 0.09 % sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Aliquot the SET07 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    SETD8 (SET Domain Containing (Lysine Methyltransferase) 8 (SETD8))
    Alternative Name
    SET07 (SETD8 Products)
    Synonyms
    KMT5A antibody, PR-Set7 antibody, SET07 antibody, SET8 antibody, 2410195B05Rik antibody, AA617402 antibody, AW536475 antibody, PR-SET7 antibody, setd8b antibody, wu:fc23f12 antibody, zgc:171649 antibody, Pr-set7 antibody, RGD1305893 antibody, Setd8 antibody, kmt5a antibody, kmt5a-a antibody, setd8 antibody, setd8-a antibody, lysine methyltransferase 5A antibody, lysine methyltransferase 5Ab antibody, lysine methyltransferase 5A S homeolog antibody, KMT5A antibody, Kmt5a antibody, kmt5ab antibody, kmt5a.S antibody
    Background
    SET07 is a protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration. [UniProt]
    UniProt
    Q9NQR1
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