SET Domain Containing (Lysine Methyltransferase) 8 Proteins (SETD8)

Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Additionally we are shipping SETD8 Antibodies (142) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SETD8 387893 Q9NQR1
SETD8 67956 Q2YDW7
Rat SETD8 SETD8 689820  
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Top SETD8 Proteins at antibodies-online.com

Showing 10 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
Details
Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 14 to 16 Days
$382.80
Details
Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Log in to see Available
$284.90
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 60 to 71 Days
$2,907.67
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Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,959.00
Details
Yeast Schizosaccharomyces pombe His tag   1 mg Log in to see 60 to 71 Days
$3,197.33
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Baculovirus infected Insect Cells Human His tag   50 μg Log in to see 13 to 16 Days
$400.00
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Escherichia coli (E. coli) Human His tag   10 μg Log in to see 1 to 2 Days
$460.83
Details
Escherichia coli (E. coli) Human His tag   10 μg Log in to see 1 to 2 Days
$460.83
Details

SETD8 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,

Mouse (Murine)

More Proteins for SET Domain Containing (Lysine Methyltransferase) 8 (SETD8) Interaction Partners

Human SET Domain Containing (Lysine Methyltransferase) 8 (SETD8) interaction partners

  1. Results suggest that SET domain-containing protein 8 (SET8) may be a key mediator in hyperglycemic memory.

  2. that oncogenic SETD8 was regulated by miR (show MLXIP Proteins)-382 and involved glioma progression

  3. Data found that KMT5A was overexpressed in papillary thyroid carcinoma (PTC (show F9 Proteins)) tumors. Its knockdown revealed that KMT5A participated in the proliferation, apoptosis, cell cycle, migration and invasion of PTC (show F9 Proteins) cells as well as attenuated fatty acid metabolism. These results provide mounting evidence of KMT5A as an oncogenic mediator in fatty acid metabolism of PTC (show F9 Proteins).

  4. Authors demonstrated that PR-Set7, an epigenetic regulator for H4K20me1 modification, was extensively expressed in the postnatal uteri, and its conditional deletion resulted in a complete lack of endometrial glands and infertility in mice.

  5. MiR (show MLXIP Proteins)-502 medaited histone methyltransferase SET8 expression is associated with outcome of esophageal squamous cell carcinoma.

  6. these date elucidated that NT21MP and miR335 mediated PR of breast cancer cells partly through regulation of Wnt (show WNT2 Proteins)/betacatenin signaling pathway. Activation of miR335 or inactivation of SETD8 could be a novel approach for the treatment of breast cancer.

  7. High expression of SET8 is associated with cervical cancer.

  8. This improves the binding of SAM (show TTN Proteins), SAH (show ACSM3 Proteins), and sinefungin by up to 10,000-fold. A small collection of inhibitors structurally related to SAM (show TTN Proteins) were screened and 40 compounds were identified that only inhibit SETD8 when a nucleosome substrate is used

  9. We demonstrated the expression levels of SET8 in TT genotype were higher than in CC genotypes, and high levels of SET8 were associated with poor survival in breast cancer

  10. Lysine methylation represses p53 (show TP53 Proteins) activity in teratocarcinoma cancer cells via up-regulation of SMYD2 and PR-Set7 and perpetuation of cancer cells proliferation.

Mouse (Murine) SET Domain Containing (Lysine Methyltransferase) 8 (SETD8) interaction partners

  1. Authors demonstrated that PR-Set7, an epigenetic regulator for H4K20me1 modification, was extensively expressed in the postnatal uteri, and its conditional deletion resulted in a complete lack of endometrial glands and infertility in mice.

  2. PR-Set7 is a direct target of Cul4A (show CUL4A Proteins) for degradation and involved in the formation of lung tumors in the conditional Cul4A (show CUL4A Proteins) transgenic mouse model.

  3. These results suggest that Setd8 is an important regulator of erythroid maturation that works in part through repression of Gata2 (show GATA2 Proteins) expression.

  4. These results establish SetD8 as a determinant of erythroid cell maturation and provide a framework for understanding how a broadly expressed histone-modifying enzyme mediates cell-type-specific GATA factor function.

  5. all of the H3K36-specific methyltransferases, including ASH1L (show ASH1L Proteins), HYPB, NSD1, and NSD2 (show WHSC1 Proteins) were inhibited by ubH2A, whereas the other histone methyltransferases, including PRC2, G9a (show EHMT2 Proteins), and Pr-Set7 were not affected by ubH2A.

  6. Data indicate a vital link between GATA-1 (show GATA1 Proteins) and the histone H4 lysine 20 methyltransferase PR-Set7/SetD8 (SetD8).

  7. Pr-set7 knockdown caused increased gammaH2AX (show H2AFX Proteins) foci on chromosomes indicating DNA damage on chromosomes.

  8. Setd8 is a crucial inhibitor of apoptosis in skin and its activity is essential for epidermal stem cell survival, proliferation and differentiation

  9. the SET8 and PCNA (show PCNA Proteins) interaction couples H4-K20 (show KRT20 Proteins) methylation with DNA replication

  10. PR-Set7 enzymatic activity is essential for mammalian cell cycle progression and for the maintenance of genomic stability, most likely by monomethylating histone H4K20.

SETD8 Protein Profile

Protein Summary

Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes (By similarity).

Gene names and symbols associated with SETD8

  • lysine methyltransferase 5A (KMT5A)
  • lysine methyltransferase 5A (Kmt5a)
  • lysine methyltransferase 5Ab (kmt5ab)
  • lysine methyltransferase 5A S homeolog (kmt5a.S)
  • 2410195B05Rik protein
  • AA617402 protein
  • AW536475 protein
  • kmt5a protein
  • kmt5a-a protein
  • Pr-set7 protein
  • RGD1305893 protein
  • SET07 protein
  • SET8 protein
  • setd8 protein
  • setd8-a protein
  • setd8b protein
  • wu:fc23f12 protein
  • zgc:171649 protein

Protein level used designations for SETD8

H4-K20-HMTase SETD8 , H4-K20-specific histone methyltransferase , H4K20-specific histone methyltransferase splice variant Set8b , N-lysine methyltransferase SETD8 , PR/SET domain containing protein 8 , PR/SET domain-containing protein 07 , PR/SET07 , SET domain-containing protein 8 , histone-lysine N-methyltransferase SETD8 , lysine N-methyltransferase 5A , PR-Set7 , SET domain-containing 8 , SET domain containing (lysine methyltransferase) 8b , SET domain containing 8b , N-lysine methyltransferase KMT5A , SET domain containing (lysine methyltransferase) 8 , histone methyltransferase Pr-set7/Set8 , lysine (K)-specific methyltransferase 5A , Histone-lysine N-methyltransferase KMT5A-A , Lysine-specific methylase 5A-A , N-lysine methyltransferase KMT5A-A , N-lysine methyltransferase SETD8-A , SET domain-containing protein 8-A , histone-lysine N-methyltransferase KMT5A-A , histone-lysine N-methyltransferase SETD8-A , lysine (K)-specific methyltransferase 5A S homeolog , lysine-specific methylase 5A-A

GENE ID SPECIES
387893 Homo sapiens
67956 Mus musculus
532622 Bos taurus
100004770 Danio rerio
689820 Rattus norvegicus
100158384 Xenopus laevis
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