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SH2B1 encodes a member of the SH2-domain containing mediators family. Additionally we are shipping SH2B Adaptor Protein 1 Antibodies (64) and SH2B Adaptor Protein 1 Kits (1) and many more products for this protein.
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This study is the first to show that neuronal SH2B1, a key protein in insulin (show INS Proteins) signaling, may have a role in the accumulation of Abeta42 in an animal model of Alzheimer's Disease.
Chromosome microarray analysis was performed on both twins and their parents. An identical 244 kb microdeletion on 16p11.2 including 9 Refseq genes, including SH2B1, was identified in the twins.
SH2B1 fine-tunes global-local chromatin states.
SH2B1 and RABEP1 genetic variants are associated with worsening of LDL and glucose parameters in patients treated with psychotropic drugs
SH2B1 polymorphisms are associated with HbA1c, largely independent of BMI, in European American young adults.
Results identified SH2B as a functional target of miR (show MLXIP Proteins)-361 which down-regulation suppresses lung cancer progression and metastasis through regulation of SH2B1.
that SH2B1 is a key positive mediator of pathological cardiac hypertrophy
Mutation analysis has demonstrated that variation in the SH2B1 gene is frequent in both lean and obese groups, with distinctive variations being present on either side of the weight spectrum.
The rs7359397 (SH2B1) was associated with the body weight, body mass index, and truncal fat mass reduction.
4 novel variants in SH2B1 were identified in individuals with obesity and insulin (show INS Proteins) resistance.
data identify SH2B1 as a major regulator of IRS2 (show IRS2 Proteins) stability, demonstrate a novel feedback mechanism linking mTORC1 signaling with IRS2 (show IRS2 Proteins), and identify 4E-BP2 (show EIF4EBP2 Proteins) as a major regulator of proliferation and survival of beta-cells.
SH2B1 in pancreatic beta-cells promotes insulin (show INS Proteins) synthesis and secretion at least in part by enhancing activation of JAK2 (show JAK2 Proteins) and/or Pdx1 (show PDX1 Proteins) pathways in response to hormonal and nutritional signals.
hepatic SH2B1 is not required for the maintenance of normal insulin (show INS Proteins) sensitivity and glucose metabolism; however, it regulates liver triacylglycerol synthesis, lipolysis, and VLDL secretion.
These data indicate that SH2B1 in beta-cells is an important prosurvival and proproliferative protein and promotes compensatory beta-cell expansion in the insulin (show INS Proteins)-resistant state and in response to beta-cell stress.
SH2B1 is responsive to erythropoietin (show EPO Proteins) stimulation and becomes phosphorylated
Leptin (show LEP Proteins)-stimulated activation of hypothalamic JAK2 (show JAK2 Proteins) and phosphorylation of hyphothalamic IRS2 (show IRS2 Proteins) were significantly impaired in SH2B1(-/-) mice.
Mutations in the SH2 domain of SH2B1 may increase the susceptibility to obesity and type 2 diabetes in a dominant-negative manner.
Genetic deletion of SH2B1 also resulted in growth retardation, obesity, and type 2 diabetes in mice; surprisingly, life span and oxidative resistance were reduced in SH2B1 null mice.
These results suggest that SH2-Bbeta regulation of Akt (show AKT1 Proteins) partly participates in the NGF (show NGFB Proteins)-mediated development of allergic airway challenge.
This gene encodes a member of the SH2-domain containing mediators family. The encoded protein mediates activation of various kinases and may function in cytokine and growth factor receptor signaling and cellular transformation. Alternatively spliced transcript variants have been described.
SH2B adapter protein 1
, SH2B adaptor protein 1
, SH2B adapter protein 1-like
, SH2 domain-containing protein 1B
, SH2 domain-containing putative adapter SH2-B
, SH2-B signaling protein
, pro-rich, PH and SH2 domain-containing signaling mediator
, SH2-B PH domain containing signaling mediator 1
, SH2-B PH domain-containing signaling mediator 1
, fceRI gamma-chain-interacting protein SH2-B