anti-SLIT and NTRK-Like Family, Member 1 (SLITRK1) Antibodies

Human SLIT and NTRK-Like Family, Member 1 (SLITRK1) interaction partners

1. Our results indicate an important influence of the neurodevelopment genes, PBX1, LMX1A, and SLITRK1 in obsessive-compulsive disorder susceptibility

2. Altogether, these results demonstrate that Slitrk family proteins regulate synapse formation.

3. Data provide partial support for the implication of SLITRK1 in the pathogenesis of Tourette syndrome.

4. the N400I variant of SLITRK1 may have a role in obsessive-compulsive disorder

5. The study of chromosomal aberrations in Tourette syndrome etiology has implicated multiple genes, with SLITRK1 being the most prominent example.

6. One of the few genes that has been linked to TS is the SLITRK1 (Slit and Trk-like 1) gene, where four variations have been suggested as possible disease-associated changes

7. DM1 motoneuron/muscle cell cocultures showed alterations that are consistent with the known role of SLITRK genes in neurite outgrowth, neuritogenesis, and synaptogenesis; functional defects can be directly attributed to SLITRK misexpression.

8. The study of this study support that SLITRK1 var321 is association to Tourette syndrome.

9. findings support the association of rare SLITRK1 sequence variants with Tourette's syndrome

10. SLITRK1 trouble in Tourette's syndrome.

11. No variation in patients susceptible to obsessive-compulsive disorder.(

12. Rare variations in SLITRK1 result in disorders of the obsessive-complusive disease spectrum

13. negative results of the SLITRK1 analysis point to genetic heterogeneity in Tourette syndrome

14. identified four new variants for Gilles de la Tourette syndrome

15. Genetic screening in the Slit and Trk-like 1 gene for the recently identified mutations does not appear to be of utility in the diagnosis of Tourette syndrome.

16. Observed transmission is lacking of SLITRK1 var321 from an affected parent to a child with Tourette syndrome in two families segregating this variant.

17. These findings provide the first support for the original finding indicating SLITRK1 as a susceptibility gene for Gilles de la Tourette Syndrome

18. We report the psychopathological features in a large Italian family with Gilles de la Tourette syndrome not linked to the SLITRK1 gene.

19. results provide no evidence for SLITRK1 playing a major role in Tourette disease

Mouse (Murine) SLIT and NTRK-Like Family, Member 1 (SLITRK1) interaction partners

1. These results lead us to conclude that noradrenergic mechanisms are involved in the behavioral abnormalities of Slitrk1-deficient mice. Elevated anxiety due to Slitrk1 dysfunction may contribute to the pathogenesis of neuropsychiatric diseases

2. Data show that the expression of SLITRK1 is dynamic and specifically associated with the circuits most commonly implicated in TS and related disorders, suggesting that SLITRK1 contributes to the development of corticostriatal-thalamocortical circuits.