SMURF2 ELISA Kits

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

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    Kit
Target
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    SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2)
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Application
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Reactivity
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Suggested next Filters
4 Products
Pre-coated, Samples: Cell Lysate, Tissue Homogenate
ReactivityRat
Detection MethodColorimetric, Sandwich ELISA
Detection Range0.78 ng/mL - 50 ng/mL
Order details Cat. No. ABIN4948032
$880.00
96 tests
Plus shipping costs $45.00
Delivery in 13 to 16 Business Days
ReactivityHuman
Detection MethodColorimetric,
Order details Cat. No. ABIN1131327
$875.60
96 tests
Plus shipping costs $45.00
Delivery in 15 to 18 Business Days
ReactivityMouse
Detection MethodColorimetric,
Order details Cat. No. ABIN1131328
$875.60
96 tests
Plus shipping costs $45.00
Delivery in 15 to 18 Business Days
Pre-coated, Samples: Cell Lysate, Tissue Homogenate
ReactivityRat
Detection MethodColorimetric, Sandwich ELISA
Detection Range0.781 ng/mL - 50 ng/mL
Order details Cat. No. ABIN5658835
$1,136.15
96 tests
Plus shipping costs $45.00
Delivery in 8 to 12 Business Days
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SMURF2 Antigen Profile

Protein Summary

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level (By similarity).

Gene names and symbols associated with SMURF2

  • SMAD specific E3 ubiquitin protein ligase 2 (SMURF2) antibody
  • SMAD specific E3 ubiquitin protein ligase 2 (smurf2) antibody
  • SMAD specific E3 ubiquitin protein ligase 2 (Smurf2) antibody
  • SMAD specific E3 ubiquitin protein ligase 2 S homeolog (smurf2.S) antibody
  • 2810411E22Rik antibody
  • AI558114 antibody
  • AI649275 antibody
  • RGD1310067 antibody
  • SMURF2 antibody
  • wu:fb82a11 antibody
  • wu:fc41c02 antibody

Protein level used designations for SMURF2

SMAD specific E3 ubiquitin protein ligase 2 , E3 ubiquitin-protein ligase SMURF2-like , e3 ubiquitin-protein ligase SMURF2-like , E3 ubiquitin ligase SMURF2 , E3 ubiquitin-protein ligase SMURF2 , SMAD ubiquitination regulatory factor 2 , SMAD-specific E3 ubiquitin-protein ligase 2 , hSMURF2 , E3 ubiquitin ligase Smurf2

GENE ID SPECIES
100064082 Equus caballus
100230714 Taeniopygia guttata
454761 Pan troglodytes
480470 Canis lupus familiaris
717902 Macaca mulatta
100038194 Xenopus (Silurana) tropicalis
100358121 Oryctolagus cuniculus
100374187 Saccoglossus kowalevskii
100386392 Callithrix jacchus
100459970 Pongo abelii
100473715 Ailuropoda melanoleuca
100603634 Nomascus leucogenys
64750 Homo sapiens
66313 Mus musculus
303614 Rattus norvegicus
427809 Gallus gallus
540826 Bos taurus
398372 Xenopus laevis
563633 Danio rerio