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SMOC2 expression was markedly up-regulated in human liver samples with non-alcoholic fatty liver disease.
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we conclude that SMOC-2 might be a novel endometrial cancer stem cell signature gene and therapeutic target for endometrial cancer.
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SMOC2 can act as an inhibitor of mineralization; there is a possible role for SMOC2 to prevent calcification disorders.
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SMOC2 was highly expressed in both peritoneal and endometrioma lesions. Considering that the genes studied participate either directly or indirectly in cellular processes that can lead to cell migration, angiogenesis, and inappropriate invasion, it is possible that the deregulation of these genes caused the development and maintenance of ectopic tissue.
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The expression of Smoc2 was significantly higher in hepatocellular carcinoma (HCC) tissues compared with corresponding non-tumor liver tissues. Smoc2 promotes the proliferation of HCC cells through accelerating cell cycle progression.
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L1-mediated CRC progression involves the acquisition of a stem cell-like phenotype, and that SMOC-2 elevation is necessary for L1-mediated induction of more aggressive/invasive CRC properties.
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could not detect an association between SMOC2 gene and AMD. This study tests the candidacy of SMOC2 gene to the etiology of AMD
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SMOC2 SNP may play a role in autoimmune thyroid disease susceptibility as a dominant polymorphism.
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mutation in exon 8 of the SMOC2 gene linked to oligodontia
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Homozygosity mapping and candidate prioritization identify mutations, missed by whole-exome sequencing, in SMOC2, causing major dental developmental defects
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The variant rs13208776 in SMOC2 gene does not play a major role in increasing the risk of vitiligo in Jordanian Arab patients.
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SMOC2 is a risk locus for generalized vitiligo and perhaps other autoimmune diseases
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identification of gene, chromosome mapping
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SMOC-2 is a novel angiogenic factor that potentiates angiogenic effects of growth factors
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We tested association between SMOC2 polymorphisms and FEV(1) and FVC. SMOC2 might play an important role in the determination of FEV(1) and FVC
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Although this study specifies rat, the authors studied and discussed the human gene in this study as well.