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The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1\; MIM 601912) is required for many cellular processes. Additionally we are shipping SENP7 Antibodies (69) and SENP7 Kits (1) and many more products for this protein.
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SPOP inhibits hepatocellular carcinoma (HCC) cell metastasis via ubiquitin-dependent SENP7 proteolysis and may thus serve as a new opinion for the prevention of HCC metastasis.
c-Myc is targeted to the proteasome for degradation in a SUMOylation-dependent manner, regulated by PIAS1, SENP7 and RNF4
deSUMOylation by SENP7 is required to promote a permissive chromatin environment for DNA repair.
differential splicing of the SENP7 regulates either tumor suppression or progression
Loop 1 insertion in SENP6 and SENP7 as a platform to discriminate between SUMO1 and SUMO2/3 isoforms in this subclass of the SUMO protease family.
SENP6 and SENP7 exhibit lower rates for processing pre-SUMO1, pre-SUMO2, or pre-SUMO3 in comparison with SENP2
SENP7 programs zygotic DNA repair and spindle assembly to facilitate maternal-to-zygotic transition. SENP7 intervenes epigenetic scenarios of histone H3 during oocyte and embryo development.
Senp7 is transiently activated at early stages of neuronal differentiation.
Depletion of Senp7 delocalizes HP1 alpha from pericentric heterochromatin without affecting H3K9me3 levels.
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1\; MIM 601912) is required for many cellular processes. SUMO-specific proteases, such as SENP7, process SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008
SUMO-1-specific protease 2
, SUMO1/sentrin specific peptidase 7
, sentrin-specific protease 7
, sentrin/SUMO-specific protease 7
, sentrin/SUMO-specific protease SENP7
, SUMO1/sentrin specific protease 7
, Sumo1/sentrin/SMT3 specific peptidase 7