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Probable transcription factor.. Additionally we are shipping SALL2 Kits (7) and SALL2 Proteins (3) and many more products for this protein.
Showing 10 out of 24 products:
Human Polyclonal SALL2 Primary Antibody for ICC, IF - ABIN4351915
Escobar, Hepp, Farkas, Campos, Sodir, Morales, Álvarez, Swigart, Evan, Gutiérrez, Nishinakamura, Castro, Pincheira: Sall2 is required for proapoptotic Noxa expression and genotoxic stress-induced apoptosis by doxorubicin. in Cell death & disease 2015
Show all 2 Pubmed References
Using RNA interference, the role of Spalt (show SALL1 Antibodies)-like gene-2 (SALL2) was investigated in human ovarian carcinoma (OC) A2780 cells. Found downregulation of SALL2 promoted growth of the OC cell line.
Understanding SALL2 function and the molecular mechanisms governing its expression and activity is critical to comprehend why and how SALL2 could contribute to disease. This knowledge will open new perspectives for the development of molecular targeted approaches in disease
Sall2 enhanced the p16 minigene blocking of cell cycle progression and p16 knockdown with siRNA abolished most of the Sall2 inhibition of cell cycle progression
Mechanisms of silencing SALL2 in OVCA cell lines and primary tumors and possible therapeutic approaches for ovarian carcinoma are discussed in this review.
A role for SALL2 in eye morphogenesis and loss of function of the gene causes ocular coloboma in humans and mice.
The SALL2 P2 promoter is hypermethylated in a majority of serous ovarian carcinomas.
c-MYC may come under negative regulation by p150, consistent with the action of p150 as a putative tumor suppressor.
Here, the authors report that human papillomavirus type 16 E6 targets the cellular factor p150(Sal2), which positively regulates p21(WAF1 (show CDKN1A Antibodies)) transcription.
Results demonstrate binding of p150(Sal2) to two natural promoters with GC elements related to the optimal binding sequence defined in vitro and whose regulation is important for suppression of tumor growth.
A CUL4/DDB1 E3 ligase containing RBBP7 (show RBBP7 Antibodies) as the p150(Sal2) receptor has been identified as mediating the destruction of p150(Sal2) as cells transition from a quiescent to an actively growing state.
In addition, studies in leukemia Jurkat T cells support the existence of the Sall2/Noxa (show PMAIP1 Antibodies) axis, and the significance of this axis on the apoptotic response to doxorubicin in cancer cells.
Data show that p53 (show TP53 Antibodies) activation diminished SALL2 RNA and protein levels during genotoxic cellular stress in primary embryo fibroblasts (MEFs).
We have now generated mice lacking Sall2.Mice lacking both Sall1 (show SALL1 Antibodies) and Sall2 show kidney phenotypes comparable to those of Sall1 (show SALL1 Antibodies) knockout, thereby demonstrating the dispensable roles of Sall2 in embryonic and kidney development
Results suggest that p150(Sal2), acting in part as a p53 (show TP53 Antibodies)-independent regulator of p21 (show D4S234E Antibodies) and BAX (show BAX Antibodies), can function in some cell types as a regulator of cell growth and survival.
These data establish Sall2 as a link between p75 neurotrophin receptor (show NGFR Antibodies) and transcriptional events that regulate the growth and development of neuronal cells.
Probable transcription factor.
sal-like protein 2
, zinc finger protein 795
, zinc finger protein SALL2
, zinc finger protein Spalt-2
, spalt-like protein 2