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May have a role in hematopoietic cell differentiation (By similarity).. Additionally we are shipping SLFN5 Antibodies (7) and SLFN5 Kits (4) and many more products for this protein.
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several mouse Slfn genes are up-regulated in response to IFN treatment of mouse melanoma and renal cell carcinoma cells, including Slfn1, Slfn2, Slfn4, Slfn5, and Slfn8.
Type-I IFN treatment triggers the interaction of STAT1 (show STAT1 Proteins) with SLFN5, and the resulting complex negatively controls STAT1 (show STAT1 Proteins)-mediated gene transcription via interferon (show IFNA Proteins) stimulated response elements
In this study population, elevated SLFN5 protein expression in patients with intestinal metaplasia correlated with progression to gastric cancer
SLFN5 exhibits key roles in controlling motility and invasiveness of renal cell carcinoma (show MOK Proteins) cells by negatively controlling expression of MMP-1 (show MMP1 Proteins), MMP-13 (show MMP13 Proteins), and several other genes involved in the control of malignant cell motility.
SLFN5 knockdown also resulted in increased invasion in three-dimensional collagen, suggesting a dual role for SLFN5 in the regulation of invasion and anchorage-independent growth of melanoma cells.
May have a role in hematopoietic cell differentiation (By similarity).
schlafen family member 5
, schlafen 5
, expressesd sequence AI956840