Sclerostin Domain Containing 1 Proteins (SOSTDC1)

SOSTDC1 is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. Additionally we are shipping SOSTDC1 Antibodies (46) and SOSTDC1 Kits (29) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat SOSTDC1 SOSTDC1 266803 Q642G2
SOSTDC1 25928 Q6X4U4
SOSTDC1 66042 Q9CQN4
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Top SOSTDC1 Proteins at antibodies-online.com

Showing 8 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
$6,749.58
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
$6,749.58
Details
Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg 15 to 18 Days
$694.00
Details
Wheat germ Human GST tag 2 μg 11 to 12 Days
$338.33
Details
Escherichia coli (E. coli) Human His tag 100 μg 15 to 19 Days
$553.85
Details
Yeast Chicken His tag   1 mg 60 to 71 Days
$2,436.50
Details
Escherichia coli (E. coli) Human His tag,T7 tag 100 μg 15 to 18 Days
$656.00
Details
Escherichia coli (E. coli) Mouse Un-conjugated   100 μg 11 to 18 Days
$554.33
Details

SOSTDC1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,

Top referenced SOSTDC1 Proteins

  1. Human SOSTDC1 Protein expressed in Wheat germ - ABIN1320977 : Lee, Miyazawa, Shin, Kwon, Kang, Choi, Lee, Kondo, Cho, Jung: Shh signaling is essential for rugae morphogenesis in mice. in Histochemistry and cell biology 2011 (PubMed)

More Proteins for Sclerostin Domain Containing 1 (SOSTDC1) Interaction Partners

Human Sclerostin Domain Containing 1 (SOSTDC1) interaction partners

  1. The present study aimed to investigate SOSTDC1 coding regions in non-syndromic patients with one or more supernumerary teeth

  2. SOSTDC1 may be a potential prognostic biomarker and therapeutic target for nonsmall cell lung cancer bone metastasis.

  3. findings provide insight into the role of SOSTDC1 as a novel functional tumor suppressor in follicular thyroid cancer through modulating the activities of PI3K/Akt and MAPK/Erk signaling pathways.

  4. Down-regulation of SOSTDC1 promotes thyroid cancer cell proliferation via regulating cyclin A2 and cyclin E2.

  5. Results conclude that the transcriptional repressor E4BP4 plays a role in repressing epigenetically regulated SOSTDC1 expression in breast cancer cells, which can be reverted by E4BP4 silencing.

  6. Epigenetic silencing of SOSTDC1 through methylation is increased in prostate cancer and is associated with accelerated disease progression in patients with prostate cancer

  7. Unliganded VDR upregulates the expression of hairless, the gene product of which acts as a downstream comodulator to feedback-repress DKKL1 and SOSTDC1.

  8. DNA methylation is involved in the down-regulation of SOSTDC1 expression in gastric cancer.

  9. SOSTDC1 is expressed in normal breast tissue and this expression is reduced in breast cancer.

  10. Results indicate for the first time that the genetic polymorphisms in SOSTDC1 have an effect on attainment and maintenance of peak bone mass in Chinese women.

  11. genetic aberrations near SOSTDC1 are not uncommon in renal cancer, and occur in adult as well as pediatric renal tumors.

  12. Data suggest that ectodin is a novel bone morphogenetic protein (BMP) inhibitor which integrates BMP signaling with the SHH and FGF signal pathways

  13. USAG1 is expressed in the kidney and functions as a bone morphogenetic protein antagonist.

  14. This screen identified a bone morphogenetic protein (BMP) antagonist, SOSTDC1 (sclerostin domain-containing-1) as down-regulated in kidney tumors.

  15. Loss of SOSTDC1 gene is associated with Wilms tumor.

Mouse (Murine) Sclerostin Domain Containing 1 (SOSTDC1) interaction partners

  1. Wise and Lrp4 are thus likely to control palatal rugae development by regulating reaction-diffusion mechanisms through Shh and Fgf signaling.

  2. Sostdc1 may promote and maintain mesenchymal stem cell quiescence in the periosteum.

  3. suggest that RUNX2 and USAG-1 act in an antagonistic manner

  4. the in vivo inter-relationships between Bmp7 and Usag-1, was examined.

  5. Findings strongly suggest that Wise and Sost are key modulators of bone development through the ability of their encoded proteins to interact with Lrp5 and control the balance or levels of Wnt signaling.

  6. Interactions between BMP-7 and USAG-1 (uterine sensitization-associated gene-1) regulate supernumerary organ formations

  7. Sost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner.

  8. Wise controls the number and distribution of the mammary epithelial cells via inhibition of Wnt/beta-catenin signaling.

  9. Data suggest that Sostdc1 primarily regulates bone morphogenetic protein pathway in pancreatic islets; knockout/mutation of Sostdc1 enhances down-regulation of Ctgf (connective tissue growth factor) and gremlin in islets after high-fat diet.

  10. The data demonstrate that simvastatin contributes to prevent the progression of renal fibrosis by upregulating BMP-7-mediated anti-fibrotic signaling and that one aspect of crucial efficacies is achieved by regulating HOXA13 and USAG-1.

  11. The data suggested that functions of Sostdc1 can be largely attributed to its ability to attenuate Wnt/beta-catenin signaling.

  12. We propose a new reaction-diffusion model in which Wnt, Shh and Sostdc1 act as the activator, mediator and inhibitor, respectively, and confirm that such interactions can generate the tooth pattern of a wild-type mouse.

  13. analyses demonstrate that the Fgf and Shh pathways are major downstream targets of Wise-regulated Wnt signaling.

  14. the pathogenetic role of USAG-1 in Col4a3-/- mice might involve crosstalk between kidney tubules and the glomerulus and that inhibition of USAG-1 may be a promising therapeutic approach for the treatment of Alport syndrome.

  15. Data suggest that ectodin is a novel bone morphogenetic protein (BMP) inhibitor which integrates BMP signaling with the SHH and FGF signal pathways

  16. reported that ectodin, a secreted bone morphogenetic protein (BMP) inhibitor, is expressed as a "negative" image of enamel knots; proposed that ectodin is critical for robust spatial delineation of enamel knots and cusps

  17. Uterine sensitization-associated gene-1 (USAG-1) plays a critical role in the modulation of renoprotective action of bone morphogenetic protein.

  18. Expression of USAG-1 mRNA appears to be associated with blastocyst implantation to the luminal epithelium, suggesting that physiological or biochemical contact of the blastocyst to the uterus is required for USAG-1 expression

  19. USAG-1 controls the number of teeth in the maxillary incisor region by regulating apoptosis

  20. Enhanced BMP signaling results in supernumerary teeth and BMP signaling was modulated by Wnt signaling in the USAG-1 deficient mouse model.

SOSTDC1 Protein Profile

Protein Summary

This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death.

Gene names and symbols associated with SOSTDC1

  • sclerostin domain containing 1 (SOSTDC1)
  • sclerostin domain containing 1a (sostdc1a)
  • sclerostin domain containing 1 (Sostdc1)
  • 0610006G05Rik protein
  • DKFZp469J0531 protein
  • ectodin protein
  • SOSTDC1 protein
  • Sostl protein
  • USAG-1 protein
  • USAG1 protein
  • WISE protein
  • zgc:110293 protein

Protein level used designations for SOSTDC1

sclerostin domain containing 1 , sclerostin domain-containing protein 1 , Sclerostin domain-containing protein 1 , USAG-1 , uterine sensitization-associated gene 1 protein , wnt-signaling modulator , cystine-knot containing secreted protein , ectodermal BMP inhibitor , uterine sensitization-associated protein-1 , sclerostin-like protein , uterine sensitization-associated protein 1 , context-dependent activator and inhibitor of Wnt signalling protein Wise

GENE ID SPECIES
482331 Canis lupus familiaris
550261 Danio rerio
100173799 Pongo abelii
266803 Rattus norvegicus
25928 Homo sapiens
66042 Mus musculus
378800 Gallus gallus
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