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The encoded protein is a secreted calcium-binding protein which is found in the cytoplasm.
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Secretagogin-dependent MMP2 (show MMP2 ELISA Kits) release from neurons regulates neuroblast migration.
The low SCGN plasma levels in children with ASD (show ARSD ELISA Kits) probably indicate that SCGN might be implicated in the pathogenesis of autism. However, these data should be treated with caution until further investigations are performed using larger sample sizes to determine whether the decrease in plasma SCGN levels is a mere consequence of autism or it plays a pathogenic role in the disease.
Therefore, and considering the desensitization of TRPV1s in diabetic pancreata, a TRPV1 (show TRPV1 ELISA Kits)-to-secretagogin regulatory axis seems critical to maintain the structural integrity and signal competence of beta-cells.
These results suggest SCGN is involved in the chemoresistance of small cell lung cancer under the regulation of miR (show MLXIP ELISA Kits)-494
Scgn is a CaBP expressed in a subpopulation of nociceptive DRG neurons and their processes in the dorsal horn.
While secretagogin mRNA was detected in both peripheral mononuclear cells and erythrocytes using reverse-transcription polymerase chain reaction, SCGN protein was only detected in erythrocytes.
Data show that the density of secretagogin-positive neurons selectively decreases in the olfactory tract in Alzheimer's disease.
Levels of secretagogin correlate with mortality and are useful as predictors of outcome in children with traumatic brain injury.
Ddetection of novel calcium-binding protein secretagogin within subgroup of clear-cell renal cell carcinomas. Increased metastasis rates within secretagogin-positive subgroup of clear-cell renal cell carcinomas.
Results emphasize the developmentally shared origins of neurons populating the extended amygdala, and suggest that secretagogin can be relevant to the generation of functional modalities in specific neuronal circuitries.
X-ray structure of Danio rerio secretagogin: A hexa (show HEXA ELISA Kits)-EF-hand calcium sensor
Secretagogin affects insulin secretion in pancreatic beta-cells by regulating actin dynamics and focal adhesion
Scgn is a redox-responsive Ca(2 (show CA2 ELISA Kits)+) sensor.
these data define a novel secretagogin neuronal locus and molecular axis underpinning stress responsiveness.
The Sirt1 (show SIRT1 ELISA Kits)/DDAH2 (show DDAH2 ELISA Kits)/secretagogin pathway is a novel regulator of glucose-stimulated insulin (show INS ELISA Kits) secretion
scgn is a marker of neuroblasts commuting in the rostral migratory stream. Terminally differentiated neurons in the olfactory bulb retain scgn expression, with scgn being present in periglomerular cells and granular layer interneurons.
The encoded protein is a secreted calcium-binding protein which is found in the cytoplasm. It is related to calbindin D-28K and calretinin. This protein is thought to be involved in KCL-stimulated calcium flux and cell proliferation.
secretagogin, EF-hand calcium binding protein