Secretin Receptor (SCTR) ELISA Kits

Human Secretin Receptor (SCTR) interaction partners

1. elevated in primary sclerosing cholangitis liver samples compared to healthy controls

2. Structure and Function of Cross-class Complexes of G Protein-coupled Secretin and Angiotensin 1a Receptors.

3. Cysteine trapping identified charge-charge interactions between secretin and secretin receptor residues in TM5, TM6, ECL2, and ECL3 domains.

4. Our findings indicate that SCTR suppresses the proliferation of normal breast cells, while the gene stimulates the proliferation and migration of cancer cells being downregulated by promoter methylation.

5. High SCTR expression is associated with liver metastases of pancreas neuroendocrine tumors.

6. Results suggest that Secretin is a potent modulator of adipocyte functions, demonstrating overall a role in enhanced substrate cycling.

7. Taken together, we propose here that the down-regulatory effects of NRSF on hSCTR gene expression are mediated via its suppression on Sp1-mediated transactivation.

8. Data suggest that the interaction between secretin peptide residue H1 and secretin receptor residue W274 is most compatible with a hydrophobic interaction.

9. binding and activity of a series of 11 truncated and lactam-constrained secretin(5-27) analogues at the prototypic member of this family, the secretin receptor

10. results demonstrate that secretin and/or the modulation of SCTR expression might have potential as a therapeutic tool in the treatment of cholangiocarcinoma

11. Increasing expression of secretin receptor competes for receptor modifying protein 3 (RAMP3) association with calcitonin receptor-like receptor (CLR) to yield a functional adrenomedullin receptor.

12. promoter methylation plays a role in the regulation of SR gene expression.

13. Secretin receptor transcripts are present in Purkinje cells and basket cells in the molecular cell layer of human cerebellum.

14. There is a marked reduction in SCTR binding in ductal neoplasia.

15. Secretin receptor oligomerization occurs through -GxxxG- motif-independent interactions of transmembrane segments during the maturation of nascent molecules.

16. The high receptor expression in cholangiocarcinomas may be used for in vivo secretin receptor-targeting of these tumors and for the differential diagnosis with hepatocellular carcinoma.

17. A novel abnormal spliceoform of the secretin receptor was identified in pancreatic and bile duct cancers and developed as a dual antibody sandwich enzyme-linked immunosorbent assay for measure in the circulation.

18. Secretin-receptor and secretin-receptor-variant expressions occur in all gastrinomas

19. secretin receptors are new markers for bronchopulmonary carcinoid tumors

20. Data show that Family B G-protein-coupled receptor oligomerization occurs, with many structurally related members, such as the secretin receptor,associating with each other.

Mouse (Murine) Secretin Receptor (SCTR) interaction partners

1. Enhanced senescence levels in cholangiocytes from Mdr2(-/-) mice were reversed to normal in SR(-/-)/Mdr2(-/-) mice.

2. Knockout of SCTR results in defective aldosterone biosynthesis/release and altered sensitivity of ENaCs to amiloride.

3. Data show that upon heteromer formation with secretin receptor (SCTR), R137H, a nephrogenic diabetes insipidus (NDI)-causing vasopressin receptor 2 (AVPR2) mutant that is defective in trafficking to cell surface, can functionally be rescued.

4. The secretin/SR axis plays a key role in regulating the biliary contribution to cholestasis-induced hepatic fibrosis.

5. Structure and Function of Cross-class Complexes of G Protein-coupled Secretin and Angiotensin 1a Receptors.

6. In vivo, osmotic stress up-regulates the SCTR gene in the kidney cortex and medulla of wild-type mice, but does not do so in NFAT5(+/-) mice.

7. Animal studies demonstrate that secretin receptor deficiency slightly, but significantly, prolongs incubation time in female but not male mice.

8. Despite similar food intake, SCTR(-/-) mice have less weight, less fat, less hyperleptinemia and better glucose/insulin tolerance on a high-fat diet, and less intestinal fatty acid absorption but similar energy expenditure and locomotor activity.

9. Immunohistochemical staining of the arcuate nucleus shows colocalization of Sctr with proopiomelanocortin that provide proof of signals downstream to the paraventricular nucleus that lead to food intake reduction.

10. Secretin-deficient mice exhibit decreased numbers of new neurons and increased apoptosis of progenitor cells in the dentate gyrus.

11. Findings identify SCT and SCTR as novel elements of the ANGII osmoregulatory pathway in maintaining fluid balance in the body.

12. Stable knockdown of SR expression reduced basal cholangiocyte proliferation. SR is an important trophic regulator sustaining biliary growth.

Cow (Bovine) Secretin Receptor (SCTR) interaction partners

1. data indicate that secretin exerts a direct action on pancreatic secretion through specific SEC-R coupled to the adenylate cyclase system