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The protein encoded by SCG2 is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins.
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Differential Reovirus-Specific and Herpesvirus-Specific Activator Protein 1 (show FOSB ELISA Kits) Activation of Secretogranin II Leads to Altered Virus Secretion.
present data show that SgII is highly expressed in advanced prostate cancer and may contribute to the neuroendocrine differentiation by promoting the formation of secretory granules and the proliferation of PCa cells.
SN induces MUC5AC hypersecretion in a dose- and time-dependent manner; moreover, the MUC5AC over synthesis induced by SN is strongly associated with the enhanced binding of EGF (show EGF ELISA Kits) to NRP1 (show NELL1 ELISA Kits)
Topical secretoneurin gene therapy accelerates diabetic wound healing by interaction between heparan-sulfate proteoglycans and basic FGF (show FHL2 ELISA Kits).
CgA (show CGA ELISA Kits), CgB (show CGB ELISA Kits), and secretoneurin are detectable in feces, and collagenous colitis patients express higher values than patients with inflammatory bowel disease and controls. In treatment, fecal secretoneurin decreased to control levels in collagenous colitis.
In vivo secretoneurin improves left ventricular function, inhibits remodeling, and reduces scar formation; in the infarct border zone, secretoneurin induces coronary angiogenesis.
Circ (show SEMG2 ELISA Kits)ulating Levels of SgII are Increased in Patients with chronic, stable heart failure.
Data describe the gene expression and protein production of SgII (show SEMG2 ELISA Kits) in normal adrenal glands and pheochromocytomas with the goal to examine the molecular mechanisms leading to the marked variations in the expression of EM66 in tumoral chromaffin tissue.
This short review deals with investigations in neuroendocrine tumors (NETs) with antibodies against defined epitopes of chromogranins (Cgs) A and B and secretogranins (Sgs (show FBN1 ELISA Kits)) II and III.
More SgII (show SEMG2 ELISA Kits) immunoreactive cells were observed in phaeochromocytomas.
Scg2 is a major secretory target of REST with a cell differentiation-enhancing activity in neural stem cells.
Scg2 is a good candidate for the signal integrator required for activity-dependent plasticity such as associative learning and memory.
SgII binds directly to the secretory granule membrane and controls intracellular retention of proopiomelanocortin (show POMC ELISA Kits) in AtT-20 cells.
SgII mRNA levels were 10.5 fold upregulated in the left ventricle of animals with myocardial infarction and heart failure.
SN activates the protein kinase A (PKA) and cAMP-induced ERK (show EPHB2 ELISA Kits) signaling pathways in the LH-secreting mouse LbetaT2 pituitary cell line
The wide subcellular localization of secretogranin II in mouse brain may reflect diverse release sites of neuropeptides and secretorneurin, or suggests its role in the sorting and packaging of molecules other than neuropeptides in non-LDCV compartments.
SCG2, as well as SCG3 (show SCG3 ELISA Kits), may be a potential regulator of food intake based on its capacity to accumulate appetite-related hormones into secretory granules.
secretogranin II-derived peptide EM66 may act downstream of the trans-synaptic stimulation of the adrenal medulla by neurocrine factors
Results show the localization of secretogranin II (SgII) in the nucleus, more specifically, in the IP3-sensitive nucleoplasmic Ca2 (show CA2 ELISA Kits)+ store vesicles along with CGB (show CHGB ELISA Kits) and the IP3 receptors.
Comparative sequencing and EST (show MAP3K8 ELISA Kits) analysis revealed nine SNPs in porcine SCG2 cDNA, including seven SNPs in the coding region and two SNPs in the 3' UTR (show UTS2R ELISA Kits).
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown.
, secretogranin II (chromogranin C)
, Chromogranin C (Secretogranin II)
, secretogranin 2
, chromogranin C