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SELPLG encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes.
Showing 10 out of 294 products:
Mouse (Murine) Monoclonal SELPLG Primary Antibody for BR, FACS - ABIN1177261
Borges, Eytner, Moll, Steegmaier, Campbell, Ley, Mossmann, Vestweber: The P-selectin glycoprotein ligand-1 is important for recruitment of neutrophils into inflamed mouse peritoneum. in Blood 1997
Show all 12 Pubmed References
Human Monoclonal SELPLG Primary Antibody for CyTOF, ELISA - ABIN262947
Walcheck, Leppanen, Cummings, Knibbs, Stoolman, Alexander, Mattila, McEver: The monoclonal antibody CHO-131 binds to a core 2 O-glycan terminated with sialyl-Lewis x, which is a functional glycan ligand for P-selectin. in Blood 2002
Show all 8 Pubmed References
Human Monoclonal SELPLG Primary Antibody for BR, CyTOF - ABIN5012982
Santen, Schramm, Menger, Wang, Jeppsson, Thorlacius: P-selectin glycoprotein ligand-1 regulates chemokine-dependent leukocyte recruitment in colonic ischemia-reperfusion. in Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2008
Show all 3 Pubmed References
Human Monoclonal SELPLG Primary Antibody for Func, FACS - ABIN610433
Connolly, Chait, Duncan, Taylor: CT-guided percutaneous needle biopsy of small lung nodules in children. in Pediatric radiology 1999
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Mouse (Murine) Polyclonal SELPLG Primary Antibody for ICC, IHC - ABIN1870024
Baba, Batanova, Kitoh, Takashima: Adhesion of Toxoplasma gondii tachyzoite-infected vehicle leukocytes to capillary endothelial cells triggers timely parasite egression. in Scientific reports 2017
Human Monoclonal SELPLG Primary Antibody for CyTOF, FACS - ABIN4348165
Wake, Mori, Liu, Morioka, Teshigawara, Sakaguchi, Kuroda, Gao, Takahashi, Ohtsuka, Yoshino, Morimatsu, Nishibori: Histidine-Rich Glycoprotein Prevents Septic Lethality through Regulation of Immunothrombosis and Inflammation. in EBioMedicine 2016
The Interaction of Selectins and PSGL-1 as a Key Component in Thrombus Formation and Cancer Progression.
Studies indicate that P-selectin glycoprotein ligand-1 (PSGL-1) PSGL-1 can negatively regulate T cell function.
Results suggest that PSGL-1 may play an oncogenic role in the development of intestinal tumors, and this is likely mediated through activation of NFkB signaling by MIP (show TNPO1 Antibodies)-1g.
c-Myc (show MYC Antibodies) regulates P-selectin glycoprotein ligand-1 expression in monocytes during HIV-1 infection.
The percentage of CXCR3 (show CXCR3 Antibodies)(+) CD4 (show CD4 Antibodies)(+) TEM (show CYLD Antibodies) cells negatively correlated with the severity of the cutaneous disease in psoriasis patients. Importantly CLA(+) CD4 (show CD4 Antibodies)(+) TCM cells expressing CCR6 (show CCR6 Antibodies)(+) or CCR4 (show CCR4 Antibodies)(+)CXCR3 (show CXCR3 Antibodies)(+) negatively correlated with psoriasis severity suggesting recruitment to the skin compartment.
Platelet-leukocyte aggregations increased in acute ischemic stroke patients rapidly within 3h. The I allele of PSGL-1 M62I was associated with risk of developing acute ischemic stroke, especially large artery atherosclerosis stroke and small artery occlusion stroke. Small artery occlusion stroke patients with the II genotype of PSGL-1 M62I have the higher level of platelet-neutrophil aggregates.
The significant presence of CLA+ T cells and E-selectin (show SELE Antibodies) expressions in the OLPG suggests their involvement in the etiopathogenesis of OLP; however, only a weak correlation between CLA+ T cells and E-selectin (show SELE Antibodies) was observed.
PSGL-1 is a novel receptor for S. pneumoniae that contributes to protection against invasive pneumococcal disease.
This study provides a better understanding of the biology of P-selectin (show SELP Antibodies) and PSGL-1 and their roles in dissemination and resensitization of Multiple myeloma treatment.
Report influence of SELPLG variation on leukocyte-platelet interactions in cardiovascular disease.
results indicate that P-selectin (show SELP Antibodies) deletion significantly decreases tumor stiffness in Rip1 (show RALBP1 Antibodies)-Tag2 mice by inhibiting LOX (show LOX Antibodies) expression.
this study shows that PSGL-1 plays a fundamental role in balancing viral control and immunopathology and also functions to regulate T cell responses in the tumor microenvironment
Psgl-1 deficiency accelerates bleomycin-induced lung fibrosis and inflammation in mice through activating the PI3K/AKT (show AKT1 Antibodies) axis.
Circulating soluble P-selectin (show SELP Antibodies) must dimerize to promote inflammation and thrombosis in mice.
The results from the present study suggest that activated platelets secrete Pselectin to promote cardiac inflammation and fibrosis in Ang (show ANG Antibodies) IIinduced hypertension.
These findings indicate a novel pathway in tumor metastasis, i.e., tumor cell mediated activation of P-selectin (show SELP Antibodies) in platelets, followed by activation and secretion of Asm (show SMPD1 Antibodies) and in turn release of ceramide and tumor metastasis. The data suggest that p38 MAPK (show MAPK14 Antibodies) acts downstream from P-selectin (show SELP Antibodies) and is necessary for the secretion of Asm (show SMPD1 Antibodies).
Psgl-1 deficiency is protective against the prothrombotic effects of IL-1beta (show IL1B Antibodies) .
PSGL-1, CD43, and CD44 moved normally to the uropods of chemokine-stimulated C1galt1(-/-) neutrophils
these results demonstrate that P-selectin (show SELP Antibodies) expression on ECs is regulated in part by glycosylation mechanisms and that glycosylation inhibitors efficiently reduce the adhesion of sRBCs and leukocytes to ECs.
endothelial colony-forming cells interact with activated neutrophils via PSGL-1 and L-selectin (show SELL Antibodies)
This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.
P-selectin glycoprotein ligand 1
, cutaneous lymphocyte-associated associated antigen
, selectin P ligand
, P-selectin glycoprotein ligand 1 propeptide
, P-selectin glycoprotein ligand-1
, leukocyte cell surface adhesion molecule
, selectin, platelet (p-selectin) ligand