anti-Selectin P Ligand (SELPLG) Antibodies

SELPLG encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. Additionally we are shipping SELPLG Kits (35) and SELPLG Proteins (17) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SELPLG 6404 Q14242
SELPLG 20345  
SELPLG 363930  
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Top anti-SELPLG Antibodies at antibodies-online.com

Showing 10 out of 263 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-SELPLG Antibody Titration: 1.0 ug/ml Positive Control: Fetal Heart 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-SELPLG Antibody Titration: 1.0 ug/ml Positive Control: Fetal Heart 100 μL Log in to see 2 to 3 Days
$319.00
Details
Human Rat Un-conjugated CyTOF, ELISA, FACS, IHC, IHC (fro), IHC (p), WB Human peripheral blood lymphocytes stained with purified HECA-452, followed by anti-mouse IgG FITC Flow (Cell Surface): Cutaneous Lymphocyte Antigen (CLA) Antibody (HECA-452) [ABIN2629479] - A cell surface stain was performed on CD14+ hPBMCs with Cutaneous Lymphocyte Antigen (CLA) antibody (HECA-452) ABIN2629479 and a matched isotype control NBP2-31379. Cells were incubated in an antibody dilution of 1 ug/mL for 20 minutes at room temperature, followed by rat-Dylight 488 conjugated secondary antibody. A co-stain was performed using CD14 antibody ABIN2629478AF488. 0.1 mL Log in to see 7 to 9 Days
$418.10
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 2 to 3 Days
$275.00
Details
Human Mouse APC FACS Surface staining of human peripheral blood cells with anti-human CD162 (clone TC2). Surface staining of human peripheral blood cells with anti-human CD162 (clone TC2) APC.  100 Tests Log in to see 5 to 7 Days
$497.45
Details
Human Rabbit Un-conjugated FACS, WB SELPLG Antibody (C-term)  western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the SELPLG antibody detected the SELPLG protein (arrow). SELPLG Antibody (C-term)  flow cytometric analysis of Jurkat cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated EIA, FACS, WB flow cytometric analysis of Jurkat cells using SELPLG Antibody (C-term) Cat.-No AP53840PU-N (Right histogram) compared to a negative control cell (Left histogram). FITC-conjugated Goat-anti-Rabbit secondary antibodies were used for the analysis. Western blot analysis of SELPLG Antibody (C-term) Cat.-No AP53840PU-N in Jurkat cell line lysates (35ug/lane). This demonstrates the SELPLG antibody detected the SELPLG protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated FACS, IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human gastric adenocarcinoma labeled with Anti-CD162 Polyclonal Antibody, Unconjugated (ABIN679298) followed by conjugation to the secondary antibody Formalin-fixed and paraffin embedded human colon carcinoma labeled with Anti-CD162 Polyclonal Antibody, Unconjugated (ABIN679298) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$317.90
Details
Mouse Rat Un-conjugated BR, FACS, IP, WB   0.5 mg Log in to see 15 to 18 Days
$337.70
Details
Human Mouse PE FACS Surface staining of human peripheral blood cells with anti-human CD162 (clone TC2). Surface staining of human peripheral blood cells with anti-human CD162 (clone TC2) PE. 100 Tests Log in to see 5 to 7 Days
$497.45
Details

Top referenced anti-SELPLG Antibodies

  1. Mouse (Murine) Monoclonal SELPLG Primary Antibody for BR, FACS - ABIN1177261 : Borges, Eytner, Moll, Steegmaier, Campbell, Ley, Mossmann, Vestweber: The P-selectin glycoprotein ligand-1 is important for recruitment of neutrophils into inflamed mouse peritoneum. in Blood 1997 (PubMed)
    Show all 12 Pubmed References

  2. Human Monoclonal SELPLG Primary Antibody for CyTOF, ELISA - ABIN262947 : Walcheck, Leppanen, Cummings, Knibbs, Stoolman, Alexander, Mattila, McEver: The monoclonal antibody CHO-131 binds to a core 2 O-glycan terminated with sialyl-Lewis x, which is a functional glycan ligand for P-selectin. in Blood 2002 (PubMed)
    Show all 8 Pubmed References

  3. Human Monoclonal SELPLG Primary Antibody for BR, CyTOF - ABIN5012982 : Santen, Schramm, Menger, Wang, Jeppsson, Thorlacius: P-selectin glycoprotein ligand-1 regulates chemokine-dependent leukocyte recruitment in colonic ischemia-reperfusion. in Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2008 (PubMed)
    Show all 3 Pubmed References

  4. Human Polyclonal SELPLG Primary Antibody for WB - ABIN549541 : Amano, Ito, Ogawa, Eshima, Suzuki, Oba, Matsui, Kato, Fukui, Nakamura, Kitasato, Fukamizu, Majima: Angiotensin II type 1A receptor signaling facilitates tumor metastasis formation through P-selectin-mediated interaction of tumor cells with platelets and endothelial cells. in The American journal of pathology 2013 (PubMed)
    Show all 3 Pubmed References

  5. Human Monoclonal SELPLG Primary Antibody for Func, FACS - ABIN610433 : Connolly, Chait, Duncan, Taylor: CT-guided percutaneous needle biopsy of small lung nodules in children. in Pediatric radiology 1999 (PubMed)
    Show all 3 Pubmed References

  6. Human Monoclonal SELPLG Primary Antibody for CyTOF, FACS - ABIN4348165 : Wake, Mori, Liu, Morioka, Teshigawara, Sakaguchi, Kuroda, Gao, Takahashi, Ohtsuka, Yoshino, Morimatsu, Nishibori: Histidine-Rich Glycoprotein Prevents Septic Lethality through Regulation of Immunothrombosis and Inflammation. in EBioMedicine 2016 (PubMed)

  7. Mouse (Murine) Polyclonal SELPLG Primary Antibody for ICC, IHC - ABIN1870024 : Baba, Batanova, Kitoh, Takashima: Adhesion of Toxoplasma gondii tachyzoite-infected vehicle leukocytes to capillary endothelial cells triggers timely parasite egression. in Scientific reports 2017 (PubMed)

More Antibodies against SELPLG Interaction Partners

Human Selectin P Ligand (SELPLG) interaction partners

  1. PI3K is a signal linker between L-selectin and PSGL-1 in IL-18 transcriptional activation at the promoter level.

  2. These data indicate that cardiac surgery influences the expression of CD162, CD166 and CD195 and that the intensity of the immune system response, displayed as the change in the CD162, CD166, CD195 expression, varies, depending on the surgical technique used.

  3. PSGL1 mediated leukocyte rolling and the inflammatory response in general.PSGL1 is a ligand for Siglec-5 and interacts with Siglec-5 ectodomain.

  4. The Interaction of Selectins and PSGL-1 as a Key Component in Thrombus Formation and Cancer Progression.

  5. Studies indicate that P-selectin glycoprotein ligand-1 (PSGL-1) PSGL-1 can negatively regulate T cell function.

  6. Results suggest that PSGL-1 may play an oncogenic role in the development of intestinal tumors, and this is likely mediated through activation of NFkB signaling by MIP-1g.

  7. c-Myc regulates P-selectin glycoprotein ligand-1 expression in monocytes during HIV-1 infection.

  8. The percentage of CXCR3(+) CD4(+) TEM cells negatively correlated with the severity of the cutaneous disease in psoriasis patients. Importantly CLA(+) CD4(+) TCM cells expressing CCR6(+) or CCR4(+)CXCR3(+) negatively correlated with psoriasis severity suggesting recruitment to the skin compartment.

  9. Platelet-leukocyte aggregations increased in acute ischemic stroke patients rapidly within 3h. The I allele of PSGL-1 M62I was associated with risk of developing acute ischemic stroke, especially large artery atherosclerosis stroke and small artery occlusion stroke. Small artery occlusion stroke patients with the II genotype of PSGL-1 M62I have the higher level of platelet-neutrophil aggregates.

  10. The significant presence of CLA+ T cells and E-selectin expressions in the OLPG suggests their involvement in the etiopathogenesis of OLP; however, only a weak correlation between CLA+ T cells and E-selectin was observed.

  11. PSGL-1 is a novel receptor for S. pneumoniae that contributes to protection against invasive pneumococcal disease.

  12. This study provides a better understanding of the biology of P-selectin and PSGL-1 and their roles in dissemination and resensitization of Multiple myeloma treatment.

  13. Report influence of SELPLG variation on leukocyte-platelet interactions in cardiovascular disease.

  14. E-selectin interactions with glycoprotein ligands (CD44/hematopoietic cell E-/L-selectin ligand and PSGL-1) mediate the initial capturing of cells out of flow.

  15. CD162 staining and the staining degree, with the other standard immunohistochemical stains, were shown to be beneficial in the diagnosis of multiple myeloma disease.

  16. The solution structure of CCL19 is reported. It contains a canonical chemokine domain. Chemical shift mapping shows the N-termini of PSGL-1 and CCR7 have overlapping binding sites for CCL19 and binding is competitive.

  17. expression of P-selectin and P-selectin glycoprotein ligand-1, forming an auto-augmented loop of porcine aortic endothelial cells and platelet activation

  18. Staphylococcal SElX and SSL6 proteins bind cell surface receptors PSGL-1 and CD47, respectively.

  19. SCARB2 and PSGL-1 in human gastrointestinal tract, lung, and brain tissues correlated with the distribution of pathological changes seen in EV71 infection.

  20. P-selectin glycoprotein ligand-1 and L-selectin have roles in neutrophil recruitment and activate human endothelial colony-forming cells at the site of vessel injury

Mouse (Murine) Selectin P Ligand (SELPLG) interaction partners

  1. Mice deficient in P-Selectin presented altered immunity/tolerance balance. Absence of P-Selectin promotes splenomegaly with reduced naive T cell population, elevated activated/effector T cell subset, increased germinal center B and Tfh populations and high production of autoreactive antibodies.

  2. results indicate that P-selectin deletion significantly decreases tumor stiffness in Rip1-Tag2 mice by inhibiting LOX expression.

  3. this study shows that PSGL-1 plays a fundamental role in balancing viral control and immunopathology and also functions to regulate T cell responses in the tumor microenvironment

  4. Psgl-1 deficiency accelerates bleomycin-induced lung fibrosis and inflammation in mice through activating the PI3K/AKT axis.

  5. Circulating soluble P-selectin must dimerize to promote inflammation and thrombosis in mice.

  6. The results from the present study suggest that activated platelets secrete Pselectin to promote cardiac inflammation and fibrosis in Ang IIinduced hypertension.

  7. These findings indicate a novel pathway in tumor metastasis, i.e., tumor cell mediated activation of P-selectin in platelets, followed by activation and secretion of Asm and in turn release of ceramide and tumor metastasis. The data suggest that p38 MAPK acts downstream from P-selectin and is necessary for the secretion of Asm.

  8. Psgl-1 deficiency is protective against the prothrombotic effects of IL-1beta .

  9. PSGL-1, CD43, and CD44 moved normally to the uropods of chemokine-stimulated C1galt1(-/-) neutrophils

  10. these results demonstrate that P-selectin expression on ECs is regulated in part by glycosylation mechanisms and that glycosylation inhibitors efficiently reduce the adhesion of sRBCs and leukocytes to ECs.

  11. endothelial colony-forming cells interact with activated neutrophils via PSGL-1 and L-selectin

  12. In the absence of either PSGL-1 or E- and P-selectin.

  13. P-selectin glycoprotein ligand-1 deficiency augments G-CSF induced myeloid cell mobilization.

  14. In p-selectin knock-out mice, several antiinflammatory cytokines were significantly increased following peripheral nerve injury.

  15. the presence of endogenous selectin ligands, particularly PSGL-1 on leukocytes, is required for cancer progression.

  16. role in the negative regulation of autoimmunity

  17. Data indicate that only the combined deficiency in PSGL-1 and ESL-1 completely abrogated leukocyte recruitment.

  18. The PSGL-1-L-selectin complex-induced signaling effects on neutrophil slow rolling and recruitment in vivo demonstrate the functional importance of this pathway.

  19. P-selectin ligands are induced on a significant proportion of CD4+ T cells during inflammation within the intestine.

  20. PSGL-1 selectively controls Th1 recruitment in colitis. Whereas Th17 recruitment is independent of PSGL-1, generation of colonic Th17 cytokine requires initial Th1 recruitment.

SELPLG Antigen Profile

Protein Summary

This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with SELPLG

  • selectin P ligand (SELPLG) antibody
  • selectin, platelet (p-selectin) ligand (Selplg) antibody
  • clasper (cla) antibody
  • selectin P ligand (Selplg) antibody
  • CD162 antibody
  • CLA antibody
  • Psgl-1 antibody
  • Psgl1 antibody
  • Selp1 antibody
  • SELPG antibody
  • Selpl antibody
  • SELPLG antibody

Protein level used designations for SELPLG

P-selectin glycoprotein ligand 1 , cutaneous lymphocyte-associated associated antigen , selectin P ligand , P-selectin glycoprotein ligand 1 propeptide , P-selectin glycoprotein ligand-1 , leukocyte cell surface adhesion molecule , selectin, platelet (p-selectin) ligand

GENE ID SPECIES
6404 Homo sapiens
452211 Pan troglodytes
611673 Canis lupus familiaris
617434 Bos taurus
100034025 Equus caballus
100125963 Sus scrofa
20345 Mus musculus
12720 Mus musculus
363930 Rattus norvegicus
100712957 Cavia porcellus
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