Selenoprotein X, 1 Proteins (SEPX1)

SEPX1 encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. Additionally we are shipping Selenoprotein X, 1 Antibodies (28) and Selenoprotein X, 1 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SEPX1 51734 Q9NZV6
SEPX1 27361 Q9JLC3
SEPX1 685059 Q52KJ8
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Top Selenoprotein X, 1 Proteins at

Showing 10 out of 16 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
Escherichia coli (E. coli) Human GST tag 100 μg Log in to see 11 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Yeast Zebrafish His tag   1 mg Log in to see 60 to 71 Days
Yeast Wild boar His tag   1 mg Log in to see 60 to 71 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
Yeast Orang-Utan His tag   1 mg Log in to see 60 to 71 Days
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days

SEPX1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Selenoprotein X, 1 (SEPX1) Interaction Partners

Human Selenoprotein X, 1 (SEPX1) interaction partners

  1. In vivo, MsrB1 shRNAi can inhibit lung metastasis in metastasis model. In conclusion, MsrB1 regulates proliferation and invasion of u2os cells by affecting MAPK pathway and EMT, and MsrB1 gene may be a novel therapeutic target against tumors.

  2. FRET and co-IP assays demonstrated that Clu interacted with beta-amyloid peptide, a pathological protein of AD, which suggested a potential effect of SelR and Abeta with the aid of Clu. The interaction between SelR and Clu provides a novel avenue for further study on the mechanism of SelR in AD prevention.

  3. MsrB1 protected human lens epithelial cells against the peroxynitrite-induced F-actin disruption

  4. findings suggested that SelX played important roles in protecting LO2 cells against oxidative damage and reducing H2O2-induced apoptosis in liver cells.

  5. Selenoprotein R Protects Human Lens Epithelial Cells against D-Galactose-Induced Apoptosis by Regulating Oxidative Stress and Endoplasmic Reticulum Stress

  6. Silencing the expression of the main Msr elements-MsrA, MsrB1, or MsrB2 exacerbates sensitivity toward oxidative stress.

  7. MsrB1 plays important roles in protecting HLE cell mitochondria against oxidative damage and inhibits oxidative stress-induced apoptosis in diabetic cataracts by scavenging ROS.

  8. The results demonstrate that in human lens epithelial cells MsrB1 may play important roles in regulating redox balance and mitigating endoplasmic reticulum stress.

  9. The neutrophils expressed the highest activity Msrs. Msrs are important as antioxidant/repair systems for neutrophils, cells with enormous capacity for the generation of reactive oxidants and hence, susceptible to oxidative damage.

  10. Strong candidate gene for schizophrenia; upregulated in lymphoblastoid cells of monozygotic twins.

  11. The studies in mouse show that MsrB is a selenoprotein that exhibits high specificity for reduction of the R forms of free and protein-bound methionine sulfoxide.

Mouse (Murine) Selenoprotein X, 1 (SEPX1) interaction partners

  1. Findings suggest that MsrB1 controls immune responses by promoting anti-inflammatory cytokine expression in macrophages. MsrB1-dependent reduction of oxidized methionine in proteins may be a heretofore unrecognized regulatory event underlying immunity and inflammatory disease.

  2. Collectively, the results of this study suggest that selenoprotein MsrB1 plays a protective role against APAP-induced hepatotoxicity via its antioxidative function.

  3. MsrB1 deficiency does not increase high-fat diet-induced insulin resistance in mice.

  4. study identified the regulatory role of MsrB1 as a Mical antagonist in orchestrating actin dynamics and macrophage function

  5. MsrB1/Trx complex was studied in attempt to understand MsrB1 reduction mechanism. Using NMR data, molecular mechanics, protein docking & molecular dynamics simulations, found that intermediate MsrB1/Trx complex is stabilized by interprotein beta-layer.

  6. Analyses of fruit flies that do not express selenoproteins or express the mouse selenoprotein, methionine sulfoxide reductase B1, reveal a role of selenoproteins in stress resistance.

  7. Insights into function, catalytic mechanism, and fold evolution of selenoprotein methionine sulfoxide reductase B1 through structural analysis.

  8. Study characterized unexpected diversity of protein and mRNA forms of mammalian selenoprotein MsrB1.

  9. MsrB1 recovers TRPM6 channel activity by reducing the oxidation of Met(1755) and could, thereby, function as a modulator of TRPM6 during oxidative stress.

  10. Data show that methionine sulfoxide reductase (Msr)B1, but not MsrA, is the major methionine sulfoxide reductase in liver of mice and it is among the proteins that are most easily regulated by dietary selenium.

  11. The chemical shift index for MsrB1 indicates that the beta-sheets are the main element for the protein secondary structure.

Selenoprotein X, 1 (SEPX1) Protein Profile

Protein Summary

This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein belongs to the methionine sulfoxide reductase (Msr) protein family which includes repair enzymes that reduce oxidized methionine residues in proteins. The protein encoded by this gene is expressed in a variety of adult and fetal tissues and localizes to the cell nucleus and cytosol.

Gene names and symbols associated with Selenoprotein X, 1 Proteins (SEPX1)

  • methionine sulfoxide reductase B1a (msrb1a)
  • methionine sulfoxide reductase B1 (MSRB1)
  • methionine sulfoxide reductase B1 (msrb1)
  • selenoprotein X, 1 (Sepx1)
  • methionine sulfoxide reductase B1 (Msrb1)
  • cb687 protein
  • D17Wsu82e protein
  • DKFZp469G2418 protein
  • MsrB protein
  • MSRB1 protein
  • MsrB1-A protein
  • SelR protein
  • selX protein
  • SelX-A protein
  • Sepr protein
  • Sepx1 protein
  • sepx1a protein
  • wu:fa03e09 protein

Protein level used designations for Selenoprotein X, 1 Proteins (SEPX1)

methionine-R-sulfoxide reductase B1 , methionine-R-sulfoxide reductase B1-A , msrB1 , selenoprotein X, 1 , selenoprotein X, 1a , selenoprotein X-A , selenoprotein R , selenoprotein X 1 , selX , Methionine-R-sulfoxide reductase B1

352916 Danio rerio
416540 Gallus gallus
448399 Xenopus (Silurana) tropicalis
611032 Canis lupus familiaris
693358 Macaca mulatta
746697 Pan troglodytes
100068001 Equus caballus
100377187 Saccoglossus kowalevskii
51734 Homo sapiens
27361 Mus musculus
685059 Rattus norvegicus
100037965 Sus scrofa
100173105 Pongo abelii
618441 Bos taurus
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