Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) and Short Cytoplasmic Domain, (Semaphorin) 4A (Sema4a) ELISA Kits

Sema4a encodes a member of the semaphorin family of soluble and transmembrane proteins. Additionally we are shipping Sema4a Antibodies (107) and Sema4a Proteins (15) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Sema4a 64218 Q9H3S1
Anti-Mouse Sema4a Sema4a 20351 Q62178
Anti-Rat Sema4a Sema4a 310630  
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Top Sema4a ELISA Kits at antibodies-online.com

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Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.078 ng/mL 0.312-20 ng/mL Typical standard curve 96 Tests Log in to see 15 to 18 Days
$910.56
Details

More ELISA Kits for Sema4a Interaction Partners

Human Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) and Short Cytoplasmic Domain, (Semaphorin) 4A (Sema4a) interaction partners

  1. Human oligodendrocytes undergo apoptosis when exposed to Sema4A and take up H-ferritin for meeting iron requirements and that these functions are mediated via the Tim-1 receptor. H-ferritin can block Sema4A-mediated cytotoxicity. Sema4A is detectable in the CSF (show CSF2 ELISA Kits) of multiple sclerosis patients and HIV-seropositive persons and can induce oligodendrocyte cell death.

  2. Advanced peri (show PLIN1 ELISA Kits)-implantitis lesions showed higher levels of gene expression for Sem3A and Sem4D and lower levels of Sem4A in comparison to tissues obtained from a healthy dental implant.

  3. Here we show three families with retinal degeneration in which unaffected family members are either homozygous or heterozygous for the variant. The p.R713Q variant in SEMA4A is insufficient to cause either autosomal recessive or autosomal dominant retinitis pigmentosa and is unlikely to be pathogenic.

  4. ILT-4 (show LILRB2 ELISA Kits) is a receptor for hSEMA4A)on activated CD4 (show CD4 ELISA Kits)(+) T cells. hSEMA4A is highly expressed in human asthmatic lung tissue.

  5. Suggest a role for Plexin-B1 as a ligand and Sema4A as a receptor and characterize a reverse signaling pathway downstream of Sema4A regulating cell migration via Scrib.

  6. SEMA (show SEMA3B ELISA Kits) 4A confers doxorubicin resistance on hepatocellular carcinoma by inducing epithelialemesenchymal transition.

  7. In this review, we summarized the current findings on neuroimmune Sema4A and Sema4D (show SEMA4D ELISA Kits) molecules in chronic inflammation underlying many diseases and discussed their positive or negative impacts on the implicated molecular and cellular processes

  8. Sema4A activated the Akt (show AKT1 ELISA Kits) pathway via Plexin D1 (show PLXND1 ELISA Kits) receptor in lung fibroblasts.Lung fibroblasts show elevated levels of Sema4A expression in systemic sclerosis patients.

  9. Data suggest that increased expression of semaphorin 4A (Sema4A) is required to promote inflammation of rheumatoid arthritis (RA).

  10. Germline variants in SEMA4A predispose to familial colorectal cancer type X.

Mouse (Murine) Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) and Short Cytoplasmic Domain, (Semaphorin) 4A (Sema4a) interaction partners

  1. Suggest a role for Plexin-B1 as a ligand and Sema4A as a receptor and characterize a reverse signaling pathway downstream of Sema4A regulating cell migration via Scrib.

  2. SEMA4A is required for optimal activation of mTORC1 in CD8 (show CD8A ELISA Kits)+ T cells.

  3. Treg-cell stability can be subverted in certain inflammatory sites, but is maintained by a Sema4a-Nrp1 (show NRP1 ELISA Kits) axis-- this pathway is a potential therapeutic target that could limit Treg-cell-mediated tumour-induced tolerance without inducing autoimmunity

  4. Data indicate that both semaphorin 4A mRNA and protein were clearly detected on the earliest progenitors and were downregulated through thymic development.

  5. These results indicate the importance of the Sema4A protein conformation in human and mouse retina homeostasis.

  6. A fraction of Sema4a-deficient transgenic BALB/c mice spontaneously develop skin lesions resembling atopic dermatitis (AD) in humans.

  7. These data provide a new insight into Sema4A biology and define Sema4A as an important regulator of Th2-driven lung pathophysiology.

  8. Sema4A activates a specialized and restricted genetic program in macrophages able to sustain angiogenesis and participates in their recruitment and activation in inflammatory injuries.

  9. Sema4A regulates two distinct endosomal-sorting pathways that are critical for photoreceptor survival and phototransduction during the transition between daylight and darkness.

  10. experiments using knockout mice revealed that Sema4A but not Sema7A (show SEMA7A ELISA Kits) was required for the effect produced by Th1 (show HAND1 ELISA Kits) cells on neurite outgrowth from cortical neurons.

Sema4a Antigen Profile

Antigen Summary

This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with Sema4a

  • semaphorin 4A (SEMA4A) antibody
  • sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A (sema4a) antibody
  • sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A (Sema4a) antibody
  • semaphorin 4A (Sema4a) antibody
  • AI132332 antibody
  • CORD10 antibody
  • RP35 antibody
  • SEMA4A antibody
  • Semab antibody
  • SemB antibody

Protein level used designations for Sema4a

semaphorin B , sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A , semaphorin-4A , semaphorin-4A-like , sema B , semaphorin-B , semaphorin 4A

GENE ID SPECIES
457386 Pan troglodytes
718191 Macaca mulatta
100064005 Equus caballus
100135101 Xenopus (Silurana) tropicalis
100172970 Pongo abelii
100342051 Oryctolagus cuniculus
100401951 Callithrix jacchus
100465692 Ailuropoda melanoleuca
64218 Homo sapiens
490416 Canis lupus familiaris
20351 Mus musculus
310630 Rattus norvegicus
510239 Bos taurus
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