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Sema4a Products

(Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) and Short Cytoplasmic Domain, (Semaphorin) 4A (Sema4a))

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This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010].

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Featured Sema4a Categories

Sema4a Antibodies

High quality antibodies with extensive validation data.

Sema4a ELISA Kits

Reliable ELISA kits for a wide range of species.

Sema4a Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Sema4a Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, IF, ICC
Validations
  • (3)
Cat. No. ABIN6259185
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (3)
Cat. No. ABIN7270199
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC, FACS
Validations
  • (4)
Cat. No. ABIN7043610
Quantity 0.2 mL
Datasheet Datasheet

Recommended Sema4a ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6959353
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN822446
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN4884441
Quantity 96 tests
Datasheet Datasheet

Recommended Sema4a Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
Cat. No. ABIN1319469
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1319471
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source Human Cells
Validations
  • (1)
Cat. No. ABIN7320641
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our Sema4a products

Chiou, Lucassen, Sather, Kallianpur, Connor: "Semaphorin4A and H-ferritin utilize Tim-1 on human oligodendrocytes: A novel neuro-immune axis." in: Glia, Vol. 66, Issue 7, pp. 1317-1330, (2018) (PubMed).

Peng, Gao, Chong, Liu, Zhang: "Semaphorin 4A enhances lung fibrosis through activation of Akt via PlexinD1 receptor." in: Journal of biosciences, Vol. 40, Issue 5, pp. 855-62, (2015) (PubMed).

Mogie, Shanks, Nkyimbeng-Takwi, Smith, Davila, Lipsky, DeTolla, Keegan, Chapoval: "Neuroimmune semaphorin 4A as a drug and drug target for asthma." in: International immunopharmacology, Vol. 17, Issue 3, pp. 568-75, (2013) (PubMed).

Delgoffe, Woo, Turnis, Gravano, Guy, Overacre, Bettini, Vogel, Finkelstein, Bonnevier, Workman, Vignali: "Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis." in: Nature, Vol. 501, Issue 7466, pp. 252-6, (2013) (PubMed).

Synonyms and alternative names related to Sema4a

semaphorin 4A (SEMA4A), sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A (sema4a), sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A (Sema4a), semaphorin 4A (Sema4a), AI132332, CORD10, RP35, SEMA4A, SEMAB, Semab, SEMB, SemB

Protein level used designations for Sema4a

  • semaphorin B
  • sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
  • semaphorin-4A
  • semaphorin-4A-like
  • sema B
  • semaphorin-B
  • semaphorin 4A
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