anti-Septin 7 (SEPT7) Antibodies

Xenopus laevis Septin 7 (SEPT7) interaction partners

1. study identified control of septin localization by the planar cell polarity (PCP) protein Fritz as a crucial control point for both collective cell movement and ciliogenesis in embryos

Human Septin 7 (SEPT7) interaction partners

1. This study revealed septin7 may potentially play a proapoptotic role in podocyte under diabetic conditions.

2. we have identified septin 7, an essential cellular component implicated in the final steps of cell division, as a strong Bt-dependent gene regulatory protein binding to the promoter of CALB2.

3. The present study identified that SEPT7 was a potential target of miR5903p and demonstrated that SEPT7 is associated with mediating the proapoptotic effect of miR5903p in human osteoblast cell line hFOB 1.19.

4. SEPT7 overexpression and knockdown sept7 protein suppress the expression of 78 kDa glucoseregulated protein (GRP78), C/EBPhomologous protein (CHOP), pro-caspase3 and cleaved caspase3 and eIf 2alpha protein.

5. Study discloses both SEPT2 and SEPT7 are essential for breast cancer cell migration and invasion by controlling MEK/ERK MAPKs activation.

6. SUMOylation of human septins is critical for septin filament bundling and cytokinesis.

7. Low SEPT7 expression is associated with glioma cell invasion.

8. The results of this study found that bipolar Neural crest cells progenitors lose their polarity, retracting their processes to round for division, but generate neurons with bipolar morphology by emitting processes from the same locations as the progenitor.

9. Results show that SEPT7 is involved in glioma cell migration with the assistance of cofilin phosphomediated cytoskeleton locomotion.

10. Septin6 and Septin7 GTP binding proteins regulate AP-3- and ESCRT-dependent multivesicular body biogenesis

11. Significantly lower SEPT7 expression in encapsulated follicular variant of papillary thyroid carcinoma may be a sign of different molecular signature in this type of tissue.

12. In response to Candida albicans infection, SEPT7 forms a complex with endothelial cell N-cadherin, is required for normal accumulation of N-cadherin around hyphae, and is necessary for maximal fungal endocytosis.

13. SEPT2 forms a 1:1:1 complex with SEPT7 and SEPT9.

14. Overexpression of the yeast septin7 ortholog CDC10 also conferred resistance to the negative effects of copper as well as protecting cells from the overexpression of Bax.

15. miR-30a-5p is a bona fide negative regulator of SEPT7 and the oncogenic activity of miR-30a-5p in human gliomas is at least in part through the repression of SEPT7

16. Myeloid K562 cells express three SEPT9 isoforms, all of which have an equal propensity to hetero-oligomerize with SEPT7-containing hexamers to generate octameric heteromers.

17. Mutagenic analyses revealed that mutation of a potential phosphorylation site in SEPT7 (Y318) regulates the interaction with other septins.

18. the purification, crystallization and structure for the GTP-binding domain of human septin 7

19. Sept7 occupies the ends of hexameric building blocks which assemble into non-polarised filaments.

Horse (Equine) Septin 7 (SEPT7) interaction partners

1. These findings point to a possible pathogenetic role of septin 7 in Equine recurrent uveitis.

Cow (Bovine) Septin 7 (SEPT7) interaction partners

1. a SNP in the CDC10 gene was associated with growth-related traits in Japanese Black beef cattle

Mouse (Murine) Septin 7 (SEPT7) interaction partners

1. This study revealed septin7 may potentially play a proapoptotic role in podocyte under diabetic conditions.

2. SEPT7 regulates gross morphogenesis of the inner ear and maintains the size of the inner ear sensory epithelial area. It does not affect differentiation of hair cells and supporting cells. It exerts its effects at an early developmental stage of the inner ear.

3. Sept7-deficient T cells failed to complete cytokinesis when prompted by pharmacological activation or cytokines. In contrast, cell division was not dependent on sept7 when cell-cell contacts, such as those with antigen-presenting cells, provided a niche.

4. We identified stathmin as a key molecule aiding in septin-independent cytokinesis, demonstrated that stathmin supplementation is sufficient to override cytokinesis failure in SEPT7-null fibroblasts

5. Sept7 provides a physical scaffold for HDAC6 to achieve efficient microtubule deacetylation, thereby negatively regulating microtubule stability to an optimal level for neuritogenesis.

6. Septin 7 may regulate meiotic cell cycle progression by affecting microtubule cytoskeletal dynamics in mouse oocytes.

7. Report SEPT4/5/7 expression in mouse cochlea and roles in auditory function.

8. performed large-scale interaction screens to understand the neuronal functions of the ERK3/MK5 pathway and identified septin7 (Sept7) as a novel interacting partner of ERK3

9. In Sept9 knockout cells, long septin filaments stained for Sept7 disappeared. Instead, staining was found in short, often curved filaments and rings. Furthermore, Sept7 was no longer localized to the mitotic spindle

10. SEPT7 is involved in the regulation of subcellular-compartment formation during spermiogenesis in the mouse.