anti-Sestrin 2 (SESN2) Antibodies

SESN2 encodes a member of the sestrin family of PA26-related proteins. Additionally we are shipping Sestrin 2 Kits (23) and Sestrin 2 Proteins (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SESN2 83667 P58004
SESN2 230784 P58043
SESN2 502988  
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Top anti-Sestrin 2 Antibodies at

Showing 10 out of 55 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-SESN2 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: MCF7 cell lysate 100 μL Log in to see 2 to 3 Days
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated FACS, WB Western blot analysis of Sestrin-2 Antibody (Center) (ABIN652222) in 293 cell line lysates (35 µg/lane). Sestrin-2 (arrow) was detected using the purified polyclonal antibody. Sestrin-2 Antibody (Center) (ABIN652222) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 10 to 11 Days
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p) Immunocytochemistry/Immunofluorescence: SESN2 Antibody [NBP1-85029] - Immunofluorescent staining of human cell line A-431 shows positivity in cytoplasm. Immunohistochemistry-Paraffin: SESN2 Antibody [NBP1-85029] - Staining of human colon shows strong cytoplasmic positivity in glandular cells. 0.1 mL Log in to see 10 to 13 Days
Human Mouse Un-conjugated IF, ELISA, WB 100 μg Log in to see 7 to 9 Days
Cow Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
Human Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
Human Mouse Un-conjugated IF, IHC (p), IP, ELISA, WB Immunoperoxidase of monoclonal antibody to SESN2 on formalin-fixed paraffin-embedded human ovary, clear cell carcinoma. [antibody concentration 3 ug/ml] SESN2 monoclonal antibody (M03), clone 3B8 Western Blot analysis of SESN2 expression in K-562 100 μg Log in to see 11 to 12 Days
Human Rabbit Un-conjugated EIA, WB (LEFT) Western blot analysis of Sestrin-2 Antibody (Center) in 293 cell line lysates (35ug/lane). Sestrin-2 (arrow) was detected using the purified Pab. (RIGHT) Western blot analysis of SESN2 (arrow) using rabbit polyclonal Sestrin-2 Antibody (Center) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the SESN2 gene (Lane 2). 0.4 mL Log in to see 6 to 8 Days
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, WB Western Blot: SESN2 Antibody [NBP2-41302] - Western blot analysis of SESTRIN2 in mouse kidney tissue lysate with SESTRIN2 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide. Immunocytochemistry/Immunofluorescence: SESN2 Antibody [NBP2-41302] - Mouse kidney tissue with SESTRIN2 antibody at 20 ug/ml. 0.1 mg Log in to see 8 to 11 Days

SESN2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , , ,
Mouse (Murine) , ,

Rat (Rattus) ,

Top referenced anti-Sestrin 2 Antibodies

  1. Human Monoclonal Sestrin 2 Primary Antibody for IF, IHC (p) - ABIN566510 : Liu, Lee, Lee: Association of platelet-derived growth factor receptor ? accumulation with increased oxidative stress and cellular injury in sestrin 2 silenced human glioblastoma cells. in FEBS letters 2011 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal Sestrin 2 Primary Antibody for ICC, IF - ABIN4353033 : Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013 (PubMed)

More Antibodies against Sestrin 2 Interaction Partners

Human Sestrin 2 (SESN2) interaction partners

  1. tribbles (show TRIB1 Antibodies) pseudokinase 3(TRB3 (show TAS2R13 Antibodies)) and sestrin 2 may contribute to the development of obesity and its complications and can be considered interesting therapeutic target for the treatment of obesity

  2. Overexpression of Sesn2 downregulated the expression of autophagy genes, upregulated pro-apoptotic gene expression, and downregulated specific extracellular matrix markers in stress-induced cells.

  3. These results suggest that sestrin 2 suppresses CRC (show CALR Antibodies) cell growth through activation of the AMPK (show PRKAA1 Antibodies)/mTORC1 pathway and induction of apoptosis, and could be a novel pharmacological target for the treatment of CRC (show CALR Antibodies).

  4. This study shows that differential Sestrin2-mediated regulation of mTORC1 and mTORC2 (show CRTC2 Antibodies) is necessary for the survival of glutamine (show GFPT1 Antibodies)-depleted lung cancer cells.

  5. There was significant overexpression of serum sesn2 protein and mRNA levels in the Alzheimer's Disease group compared to Mild Cognitive Impairment and the control group.

  6. isorhapontigenin treatment induces autophagy and inhibits bladder cancer growth through MAPK8 (show MAPK8 Antibodies)-JUN (show JUN Antibodies)-dependent transcriptional induction of SESN2

  7. The results suggest that SESN2 increases degradation of HIF-1A (show HIF1A Antibodies) via AMPK (show PRKAA1 Antibodies)-PHD (show PDC Antibodies) regulation that contributes to inhibition of in vitro and in vivo tumorigenesis.

  8. simple analysis of the reported "apo (show C9orf3 Antibodies)"-Sestrin2 structure reveals the clear presence of prominent, unmodeled electron density in the leucine-binding pocket that exactly accommodates the leucine observed in the higher resolution structure.

  9. Mass spectrometry analysis, western blot and surface plasmon resonance (SPR (show SPR Antibodies)) of affinity purified sesn1 (show SESN1 Antibodies) and sesn2 proteins confirmed their identity; biophysical characteristics were observed using circular dichroism (CD) showing that sesn1 (show SESN1 Antibodies) and sesn2 have a predominant a-helical structure.

  10. The data are the first to indicate that SESN2 might be a novel prognostic marker for hepatocellular carcinoma

Mouse (Murine) Sestrin 2 (SESN2) interaction partners

  1. Sesn2 KO mice displayed enhanced expression of proinflammatory genes and activation of basilar membrane macrophages, suggesting that loss of SESN2 function provokes the immune response

  2. Aerobic physical exercise recovers Sestrin 2 protein content and induces autophagy in the skeletal muscle of old mice.

  3. While acute aerobic exercise increased Sesn1 (show SESN1 Antibodies) accumulation and induced a discrete augment of Sesn2 protein content and AMPK (show PRKAA1 Antibodies) threonine phosphorylation, chronic exercise reduced the basal levels of Sesn1 (show SESN1 Antibodies) and Sesn2 as well as of AMPK (show PRKAA1 Antibodies) threonine phosphorylation in the quadriceps muscles of C57BL/6J mice.

  4. sestrin2 has a role in suppressing sepsis by inducing mitophagy and inhibiting NLRP3 (show NLRP3 Antibodies) activation in macrophages

  5. SESN2 suppressed ER stress-mediated apoptosis. SESN2 attenuated hepatic injury in mice.

  6. Decreased Sesn2 levels in aging lead to a blunted ischemic AMPK (show PRKAA1 Antibodies) activation, alterations in substrate metabolism, and an increased sensitivity to ischemic insults.

  7. p53 (show TP53 Antibodies)-dependent coordination with SESN2 regulates AMPK (show PRKAA1 Antibodies) and mTORC1 signaling and controls parturition timing

  8. Our findings further revealed that Sesn2-induced autophagy contributed to restore the impaired insulin (show INS Antibodies) signaling through the activation of AMPK (show PRKAA1 Antibodies) signal. Even in the presence of palmitate, Sesn2 up-regulation maintained insulin (show INS Antibodies) sensitivity and glucose metabolism via AMPK (show PRKAA1 Antibodies)-dependent autophagic activation.

  9. Oleanolic acid can attenuate hepatic ischemia reperfusion injury via HO-1 (show HMOX1 Antibodies)/Sesn2 signaling pathway.

  10. suggest that TLR-mediated Sesn2 induction is dependent on AP-1 (show JUN Antibodies), Nrf2 (show NFE2L2 Antibodies), and the inhibition of ubiquitin-mediated degradation of Sesn2 and might protect cells against endotoxin toxicity

Sestrin 2 (SESN2) Antigen Profile

Protein Summary

This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions.

Gene names and symbols associated with anti-Sestrin 2 (SESN2) Antibodies

  • sestrin 2 (SESN2) antibody
  • sestrin 2 (Sesn2) antibody
  • sestrin 2 L homeolog (sesn2.L) antibody
  • sestrin 2 (sesn2) antibody
  • hi95 antibody
  • MGC81239 antibody
  • RGD1566319 antibody
  • ses2 antibody
  • SESN2 antibody
  • sest2 antibody
  • Sestrin-2 antibody

Protein level used designations for anti-Sestrin 2 (SESN2) Antibodies

hypoxia induced gene 95 , sestrin-2 , sestrin 2 , sestrin-2-like

83667 Homo sapiens
230784 Mus musculus
414641 Xenopus laevis
469167 Pan troglodytes
487335 Canis lupus familiaris
509863 Bos taurus
716904 Macaca mulatta
733499 Xenopus (Silurana) tropicalis
100056552 Equus caballus
100172219 Pongo abelii
100353543 Oryctolagus cuniculus
100397149 Callithrix jacchus
100469808 Ailuropoda melanoleuca
100592235 Nomascus leucogenys
502988 Rattus norvegicus
100719606 Cavia porcellus
100149745 Danio rerio
Selected quality suppliers for anti-Sestrin 2 (SESN2) Antibodies
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