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SESN2 encodes a member of the sestrin family of PA26-related proteins. Additionally we are shipping Sestrin 2 Kits (21) and Sestrin 2 Proteins (7) and many more products for this protein.
Showing 10 out of 53 products:
Human Monoclonal Sestrin 2 Primary Antibody for IF, IHC (p) - ABIN566510
Liu, Lee, Lee: Association of platelet-derived growth factor receptor ? accumulation with increased oxidative stress and cellular injury in sestrin 2 silenced human glioblastoma cells. in FEBS letters 2011
Show all 2 Pubmed References
Human Polyclonal Sestrin 2 Primary Antibody for ICC, IF - ABIN4353033
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013
There was significant overexpression of serum sesn2 protein and mRNA levels in the Alzheimer's Disease group compared to Mild Cognitive Impairment and the control group.
isorhapontigenin treatment induces autophagy and inhibits bladder cancer growth through MAPK8 (show MAPK8 Antibodies)-JUN (show JUN Antibodies)-dependent transcriptional induction of SESN2
The results suggest that SESN2 increases degradation of HIF-1A (show HIF1A Antibodies) via AMPK (show PRKAA1 Antibodies)-PHD (show PDC Antibodies) regulation that contributes to inhibition of in vitro and in vivo tumorigenesis.
simple analysis of the reported "apo (show C9orf3 Antibodies)"-Sestrin2 structure reveals the clear presence of prominent, unmodeled electron density in the leucine-binding pocket that exactly accommodates the leucine observed in the higher resolution structure.
Mass spectrometry analysis, western blot and surface plasmon resonance (SPR (show SPR Antibodies)) of affinity purified sesn1 (show SESN1 Antibodies) and sesn2 proteins confirmed their identity; biophysical characteristics were observed using circular dichroism (CD) showing that sesn1 (show SESN1 Antibodies) and sesn2 have a predominant a-helical structure.
The data are the first to indicate that SESN2 might be a novel prognostic marker for hepatocellular carcinoma
The up-regulation of SESN2 by mitochondrial dysfunction requires binding to ATF4 (show ATF4 Antibodies).
Sesn2 has two subdomains. The N-terminal domain reduces alkylhydroperoxide radicals through its helix-turn-helix oxidoreductase (show TXNRD1 Antibodies) motif, and the C-terminal domain interacts with GATOR2 and subsequently inhibits mTORC1.
SESN2-AMPK (show PRKAA1 Antibodies) signaling could exert a protective effect against glucose deprivation-induced cell death and that this effect is mediated by restoration of mitochondrial function.
Sesn2 is a potential tumor suppressor in lung epithelial cells. The expression level of Sesn2 may serve as a prognostic marker for Chinese lung cancer patients in the clinic.
While acute aerobic exercise increased Sesn1 (show SESN1 Antibodies) accumulation and induced a discrete augment of Sesn2 protein content and AMPK (show PRKAA1 Antibodies) threonine phosphorylation, chronic exercise reduced the basal levels of Sesn1 (show SESN1 Antibodies) and Sesn2 as well as of AMPK (show PRKAA1 Antibodies) threonine phosphorylation in the quadriceps muscles of C57BL/6J mice.
sestrin2 has a role in suppressing sepsis by inducing mitophagy and inhibiting NLRP3 (show NLRP3 Antibodies) activation in macrophages
SESN2 suppressed ER stress-mediated apoptosis. SESN2 attenuated hepatic injury in mice.
Decreased Sesn2 levels in aging lead to a blunted ischemic AMPK (show PRKAA1 Antibodies) activation, alterations in substrate metabolism, and an increased sensitivity to ischemic insults.
p53 (show TP53 Antibodies)-dependent coordination with SESN2 regulates AMPK (show PRKAA1 Antibodies) and mTORC1 signaling and controls parturition timing
Our findings further revealed that Sesn2-induced autophagy contributed to restore the impaired insulin (show INS Antibodies) signaling through the activation of AMPK (show PRKAA1 Antibodies) signal. Even in the presence of palmitate, Sesn2 up-regulation maintained insulin (show INS Antibodies) sensitivity and glucose metabolism via AMPK (show PRKAA1 Antibodies)-dependent autophagic activation.
Oleanolic acid can attenuate hepatic ischemia reperfusion injury via HO-1 (show HMOX1 Antibodies)/Sesn2 signaling pathway.
suggest that TLR-mediated Sesn2 induction is dependent on AP-1 (show JUN Antibodies), Nrf2 (show NFE2L2 Antibodies), and the inhibition of ubiquitin-mediated degradation of Sesn2 and might protect cells against endotoxin toxicity
an AMPK (show PRKAA1 Antibodies)-independent mechanism of mTORC1 inhibition by Sestrins mediated by their interaction with GATOR2, is reported.
Study found that Sestrins (1,2 and 3) can inhibit mTORC1 signaling in the absence of AMPK (show PRKAA1 Antibodies) or TSC2 (show TSC2 Antibodies). Surprisingly, when coexpressed with a GTP (show AK3 Antibodies)-bound constitutively active form of RagB (show RRAGB Antibodies) (RagBQ99L), Sestrins potentiate mTORC1 signaling in the absence of amino acids.
This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions.
hypoxia induced gene 95
, sestrin 2