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Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling (By similarity). Additionally we are shipping SHISA2 Antibodies (19) and many more products for this protein.
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Knockdown of Shisa2 inhibits the fusion of myoblasts without affecting proliferation. Conversely, Shisa2 overexpression in proliferating myoblasts inhibits their proliferation but promotes premature fusion. Interestingly, Shisa2-overexpressing nascent myotubes actively recruit myoblasts to fuse with.
The authors report here that Sonic Hedgehog (Shh)-Smoothened signaling downregulates Shisa2, which inhibits the glycosylation and cell surface presentation of Frizzled3 in rodent commissural axon growth cones.
shisa is expressed throughout embryonic development, predominantly in the anterior visceral endoderm, headfolds, somites, forebrain, optic vesicle, and limb buds
Shisa is antagonistic to Wnt and Fgf signalings
Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling (By similarity).
protein shisa-2 homolog
, shisa homolog 2
, transmembrane protein 46
, shisa-like protein 2