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Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling (By similarity). Additionally we are shipping SHISA2 Antibodies (19) and many more products for this protein.
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The authors report here that Sonic Hedgehog (Shh (show SHH Proteins))-Smoothened signaling downregulates Shisa2, which inhibits the glycosylation and cell surface presentation of Frizzled3 (show FZD3 Proteins) in rodent commissural axon growth cones.
shisa is expressed throughout embryonic development, predominantly in the anterior visceral endoderm, headfolds, somites, forebrain, optic vesicle, and limb buds
Shisa is antagonistic to Wnt (show WNT2 Proteins) and Fgf signalings
Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling (By similarity).
protein shisa-2 homolog
, shisa homolog 2
, transmembrane protein 46
, shisa-like protein 2