Sialic Acid Binding Ig-Like Lectin 5 Proteins (SIGLEC5)

SIGLEC5 encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. Additionally we are shipping SIGLEC5 Antibodies (177) and SIGLEC5 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SIGLEC5 8778 O15389
Rat SIGLEC5 SIGLEC5 292843  
SIGLEC5    
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top SIGLEC5 Proteins at antibodies-online.com

Showing 10 out of 20 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$5,262.31
Details
Human Cells Human Fc Tag 100 μg Log in to see 14 to 16 Days
$382.80
Details
CHO Cells Human Fc Tag   25 μg Log in to see 10 to 12 Days
$216.43
Details
Baculovirus infected Insect Cells Human hIgG-His-tag 50 μg Log in to see 13 to 16 Days
$1,230.77
Details
HEK-293 Cells Human Fc Tag Human Siglec-5, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 100 μg Log in to see 2 to 3 Days
$275.00
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$547.80
Details
Escherichia coli (E. coli) Human His tag   100 μg Log in to see 15 to 18 Days
$560.00
Details
HEK-293 Cells Human Fc Tag   0.1 mg Log in to see 2 to 3 Days
$515.63
Details

SIGLEC5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , ,
, , , , , ,
Mouse (Murine)
,

More Proteins for Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5) Interaction Partners

Human Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5) interaction partners

  1. PSGL1 and Siglec-5 are in close proximity at the leukocyte surface.SPSGL1 is a ligand for Siglec-5 and interacts with Siglec-5 ectodomain.Siglec-5 plays a role in PSGL1-mediated leukocyte rolling and the inflammatory response in general.

  2. An unbiased screen revealed Hsp70 as a ligand for Siglec-5 and Siglec-14. Hsp70 stimulation through Siglec-5 delivers an anti-inflammatory signal, while stimulation through Siglec-14 is pro-inflammatory.

  3. Data indicate that the Siglec-5/14 genotype influences neutrophil responses to group B Streptococcus.

  4. we found that secretory IgA is taken up by M cells via the Dectin-1 receptor, with the possible involvement of Siglec-5 acting as a co-receptor.

  5. These studies demonstrate the Siglec5 carbohydrate recognition domain alone is sufficient for binding sialylated carbohydrates and provide a foundation for further investigation of Siglec5 structure and function.

  6. Siglec-5 expression protects T cells from HIV-1- and apoptosis-induced cell death and contributes to the different outcomes of HIV-1 infection in humans and chimpanzees.

  7. Human Siglec-5 inhibitory receptor and immunoglobulin A (IgA) have separate binding sites in streptococcal beta protein.

  8. Siglec-5 expression correlates with lack of proliferation in a subset of human cells, and is upregulated by activation of chimpanzee but not human lymphocytes.

  9. expression of Siglec-5 on cells of the myelomonocytic lineage and alteration of its expression by inflammatory stimuli suggest a role for this protein in cell/cell interactions following microbial exposure.

  10. Siglec-5 can be classified as an inhibitory receptor with the potential to mediate SHP-1 and/or SHP-2-dependent signaling in the absence of tyrosine phosphorylation.

  11. Siglecs-5 did not interact with sulfate derivatives of LacNAc and sulfated oligosaccharides containing sialic acid.

  12. The expression levels of Siglec-5 were high or detectable in bone marrow plasma from AML patients and serum from normal donors.

  13. Siglec-14 and Siglec-5 appear to be the first glycan binding paired receptors. Near-complete sequence identity of the amino-terminal part of human Siglec-14 and Siglec-5 indicates partial gene conversion between SIGLEC14 and SIGLEC5.

  14. Siglec-5 is identified as a receptor for alpha-1-acid glycoprotein (AGP) 1 in human neutrophils.

  15. Structural implications of SIGLEC5-mediated sialoglycan recognition are reported.

  16. Group B Streptococcus beta protein binding to Siglec-5 functions to impair leukocyte phagocytosis, oxidative burst, and extracellular trap production, promoting bacterial survival.

SIGLEC5 Protein Profile

Protein Summary

This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion.

Gene names and symbols associated with SIGLEC5

  • sialic acid binding Ig like lectin 5 (SIGLEC5)
  • sialic acid-binding Ig-like lectin 5 (LOC100597560)
  • sialic acid binding Ig-like lectin 5 (Siglec5)
  • CD33L2 protein
  • CD170 protein
  • OB-BP2 protein
  • OBBP2 protein
  • SIGLEC-5 protein

Protein level used designations for SIGLEC5

CD33 antigen-like 2 , OB-binding protein 2 , obesity-binding protein 2 , sialic acid-binding Ig-like lectin 5 , sialic acid-binding immunoglobulin-like lectin 5 , sialic acid binding Ig-like lectin 5

GENE ID SPECIES
8778 Homo sapiens
100597560 Nomascus leucogenys
292843 Rattus norvegicus
Selected quality suppliers for SIGLEC5 Proteins (SIGLEC5)
Did you look for something else?