SIGLEC5 Products
(Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5))
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This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. [provided by RefSeq, Feb 2012].
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Featured SIGLEC5 Categories
SIGLEC5 Antibodies
High quality antibodies with extensive validation data.
SIGLEC5 ELISA Kits
Reliable ELISA kits for a wide range of species.
SIGLEC5 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SIGLEC5 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, FACS, ICC, Neut
Validations
- (4)
Cat. No.
ABIN7193301
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN7249022
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC (p)
Validations
- (1)
- (2)
Cat. No.
ABIN544592
Quantity
400 μL
Datasheet
Datasheet
Recommended SIGLEC5 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN625088
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN5510738
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN5526846
Quantity
96 tests
Datasheet
Datasheet
Recommended SIGLEC5 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7275598
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7275589
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7275613
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our SIGLEC5 products
: "Identification of lipophilic ligands of Siglec5 and -14 that modulate innate immune responses." in: The Journal of biological chemistry, Vol. 294, Issue 45, pp. 16776-16788, (2019) (PubMed).: "Soluble Siglec-14 glycan-recognition protein is generated by alternative splicing and suppresses myeloid inflammatory responses." in: The Journal of biological chemistry, Vol. 293, Issue 51, pp. 19645-19658, (2018) (PubMed).
: "Siglec expression on the surface of human, bull and ram sperm." in: Reproduction (Cambridge, England), Vol. 155, Issue 4, pp. 361-371, (2018) (PubMed).
: "Antibody-Array-Based Proteomic Screening of Serum Markers in Systemic Lupus Erythematosus: A Discovery Study." in: Journal of proteome research, Vol. 15, Issue 7, pp. 2102-14, (2016) (PubMed).
: "Structural characterisation of high affinity Siglec-2 (CD22) ligands in complex with whole Burkitt's lymphoma (BL) Daudi cells by NMR spectroscopy." in: Scientific reports, Vol. 6, pp. 36012, (2016) (PubMed).
: "Soluble Siglec-5 associates to PSGL-1 and displays anti-inflammatory activity." in: Scientific reports, Vol. 6, pp. 37953, (2016) (PubMed).
: "Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus." in: The Journal of experimental medicine, Vol. 211, Issue 6, pp. 1231-42, (2014) (PubMed).
: "Developing aptamer probes for acute myelogenous leukemia detection and surface protein biomarker discovery." in: Journal of hematology & oncology, Vol. 7, pp. 5, (2014) (PubMed).
: "Siglec-1 is a novel dendritic cell receptor that mediates HIV-1 trans-infection through recognition of viral membrane gangliosides." in: PLoS biology, Vol. 10, Issue 12, pp. e1001448, (2012) (PubMed).
: "Siglecs facilitate HIV-1 infection of macrophages through adhesion with viral sialic acids." in: PLoS ONE, Vol. 6, Issue 9, pp. e24559, (2011) (PubMed).
Synonyms and alternative names related to SIGLEC5
sialic acid binding Ig like lectin 5 (SIGLEC5), sialic acid-binding Ig-like lectin 5 (LOC100597560), sialic acid binding Ig-like lectin 5 (Siglec5), CD33L2, CD170, OB-BP2, OBBP2, SIGLEC-5Protein level used designations for SIGLEC5
- CD33 antigen-like 2
- OB-binding protein 2
- obesity-binding protein 2
- sialic acid-binding Ig-like lectin 5
- sialic acid-binding immunoglobulin-like lectin 5
- sialic acid binding Ig-like lectin 5
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