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Neu3 product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. Additionally we are shipping Neu3 Antibodies (12) and many more products for this protein.
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the expression of neuraminidases in induced regulatory T (iTreg) cells was investigated in comparison with that in other T-cell subsets and concluded that Neu3 contributes to the differentiation of iTreg cells by upregulation of FoxP3 (show FOXP3 Proteins).
radiographs revealed abnormalities in the skeletal bones of the Hexa (show HEXA Proteins)(-/-)Neu3(-/-) mice
These results suggest that NEU3 activity on exosome glycans enhances the dynamic biological behavior of these small extracellular vesicles by modifying the negative charge and steric hindrance of their glycocalyx, and that the presence of NEU3 on the exosomal surface could represent a useful marker for the detection of these nanovesicles
findings implicate NEU3 as a potential biomarker of insulin (show INS Proteins) sensitivity, and provide novel mechanistic insight into the regulation of NEU3 expression.
NEU3 regulates the detergent resistant membrane ganglioside content.
NEU3 up-regulation stimulates the EGF receptor (show EGFR Proteins) signaling pathway, which in turn activates the hypoxia-inducible factor (HIF-1alpha (show HIF1A Proteins)), resulting in a final increase of cell survival and proliferation.
NEU3 plays an important role in inflammation-dependent tumor development
Data indicate that sialidases Neu1 (show NEURL Proteins) and Neu3 are present on sperm, and their activity is required for capacitation and zona pellucida binding.
The work further supports the central role of NEU3 as a key modulator in skeletal muscle differentiation, particularly in the myoblast fusion step.
NEU3 participates in the control of insulin (show INS Proteins) signaling via modulation of gangliosides and interaction with Grb2 (show GRB2 Proteins)
This first demonstration of sialidase involvement in invasive potential of gliolastoma cells may point to NEU3 as an attractive treatment target of human gliomas
effect of overexpression on EGFR (show EGFR Proteins) downstream pathway activation and TKI targeted therapies sensitivity in non-small cell lung cancer cell lines
The most potent compound tested targeted the human Neu4 (show NEU4 Proteins) isoenzyme, and was able to substantially reduce the rate of cell migration. We found that the lateral mobility of integrins was reduced by treatment of cells with Neu3, suggesting that Neu3 enzyme activity resulted in changes to integrin-co-receptor or integrin-cytoskeleton interactions
NEU3 possesses the ability to interact with specific proteins, many of which are different in each cell compartment, supporting NEU3 involvement in the cell stress response, protein folding, and intracellular trafficking.
findings identify NEU3 as a participant in head and neck squamous cell carcinoma progression
Besides the already reported indirect EGFR (show EGFR Proteins) activation through GM3 (show GRM6 Proteins), sialidase NEU3 could also play a role on EGFR (show EGFR Proteins) activation through its desialylation.
NEU3 promotes anchorage-independent growth and in vivo tumorigenicity.
In the plasma membrane, NEU3 has a role in endocytosis and protein binding at the cell surface.
Results indicate an essential contribution of NEU3 to tumorigenic potential through maintenance of stem-like characteristics of colon cancer cells by regulating Wnt (show WNT2 Proteins) signaling at the receptor level.
The results provide strong evidence that the serum sialidase is, in fact, NEU3, and this subtype may, therefore, be a potential utility for novel diagnosis of human cancers
This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer.
, Sialidase 3 (Membrane sialidase) (Ganglioside sialidase) (N-acetyl-alpha-neuraminidase 3)
, ganglioside sialidase
, membrane sialidase
, neuraminidase 3