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Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane.
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autosomal dominant mutations in SRP54, a key member of the cotranslation protein-targeting pathway, lead to syndromic neutropenia with a Shwachman-Diamond-like phenotype.
crystal structure of a human SRP (show UCN2 Antibodies) ternary complex consisting of SRP19 (show SRP19 Antibodies), the M domain of SRP54 and the S domain of 7SL RNA
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY (By similarity).
signal recognition particle 54 kDa protein
, signal recognition particle 54
, Signal recognition particle protein subunit SRP54 (srp54)
, signal recognition particle protein Srp54
, signal recognition particle subunit Srp54
, Signal recognition particle, subunit SRP54 (srp54)
, signal recognition particle 54kDa
, signal recognition particle 54 kDa protein-like
, 54K subunit of signal recognition particle
, LOW QUALITY PROTEIN: signal recognition particle 54 kDa protein