Sirtuin 7 Proteins (SIRT7)

Human Sirtuin 7 (SIRT7) interaction partners

1. SIRT7 plays a critical role in breast cancer cell survival.

2. This study uncovers the regulatory role of SIRT7 arginine methylation in glucose sensing and mitochondria biogenesis.

3. SIRT7-elicits an autophagic response that plays a protective role against cell death and the SIRT7-inhibition has a potential to improve the efficacy of anti-metabolic therapy in non-small cell lung cancer cells.

4. SIRT7 expression was elevated in papillary thyroid cancers. SIRT7 knockdown inhibited the proliferation, colony formation, migration and invasion of thyroid cancer cells, and induced their cycle arrest and apoptosis.SIRT7 re-expression enhanced TC cell growth, invasiveness and tumorigenic potential in nude mice. SIRT7 promotes thyroid tumorigenesis by phosphorylation and activation of Akt and p70S6K1 via DBC1/SIRT1.

5. SIRT7 inhibited HAVSMCs proliferation and migration via enhancing Wnt/beta-catenin activation, which provided a novel therapeutic strategy for antiatherosclerosis.

6. Sirtuin 7 deacetylates WDR77 protein at Lys-3 and Lys-243 and thus reduces the interaction between WDR77 and PRMT5.

7. Our study provides evidence that the miR-340/SIRT7 axis may play an important role in the molecular pathogenesis of angiosarcoma.

8. Our data confirmed that SIRT7 was overexpressed in cholangiocarcinoma patient tissues and cell lines.

9. SIRT7 is involved in regulating TGF-beta1-induced ASM cell proliferation.

10. Overexpression of SIRT7 abrogated the effects mediated by miR-519d overexpression in hypertrophic scar fibroblasts.

11. SIRT7-catalysed histone H3 lysine122 desuccinylation is critically implemented in DNA-damage response and cell survival.

12. Knockdown of SIRT7 leads to the same phenotype as depletion of DDX21 (i.e., increased formation of R loops and DNA double-strand breaks), indicating that SIRT7 and DDX21 cooperate to prevent R-loop accumulation, thus safeguarding genome integrity.

13. miR-3666 is an important regulator of breast cancer development. The overexpression of miR-3666 inhibits breast cancer cell proliferation by inhibiting SIRT7.

14. Authors evaluated the expression of known targets of miR-125a and found that sirtuin-7, matrix metalloproteinase-11, and c-Raf were up-regulated in tumor tissue by 2.2-, 3-, and 1.7-fold, respectively. Overall, these data support a tumor suppressor role for miR-125a.

15. We found a negative correlation between mRNA levels of SIRT1 in VAT of obese individuals and SIRT7 in VAT of the normal-weight subjects and expression of the relevant miRNAs.

16. Data indicate the role of SIRT7 in inhibiting SMAD4-mediated breast cancer metastasis providing a possible therapeutic avenue.

17. Energy stress strengthens SIRT7-mediated effects on Akt dephosphorylation.

18. The SIRT7 is mobilized from the nucleolus to the nucleoplasm and promotes DDB1 deacetylation, leading to decreased DDB1-CUL4 association and CRL4 activity.

19. Data suggest that SIRT7 undergoes Lys-63 polyubiquitination, later removed by USP7 to repress enzymatic activity of SIRT7; USP7 and SIRT7 regulate gluconeogenesis via expression of glucose-6-phosphatase catalytic subunit (G6PC); SIRT7 targets G6PC promoter through ELK4. (SIRT7 = sirtuin 7; USP7 = ubiquitin specific peptidase 7; G6PC = glucose-6-phosphatase catalytic subunit; ELK4 = transcription factor ELK4)

20. the decline in SIRT7 in lung fibroblasts has a profibrotic effect, which is mediated by changes in Smad3 levels.

Mouse (Murine) Sirtuin 7 (SIRT7) interaction partners

1. Our results indicate that SIRT7 plays an important role in cisplatin-induced AKI and suggest the possibility of SIRT7 as a novel therapeutic target for cisplatin-induced nephrotoxicity.

2. SIRT7-elicits an autophagic response that plays a protective role against cell death and the SIRT7-inhibition has a potential to improve the efficacy of anti-metabolic therapy in non-small cell lung cancer cells.

3. The results indicate that miR-148b-3p contributes to the regulation of hypoxia/reoxygenation-induced cardiomyocyte apoptosis in vitro through targeting SIRT7 and modulating p53-mediated pro-apoptotic signaling.

4. SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7.

5. Data indicate that Sirt7 has a slight protective impact on both the adaptive immune system and neurogenesis. However, overall this epigenetic factor is not capable of impacting the acute or chronic phase of neuroinflammation.

6. Loss of SIRT7 is associated with Impairment of Adipogenesis and increased Sirt1 Activity.

7. the results of our study suggest that SIRT7 is involved in protecting neurons against OGD/R-induced injury, possibly through regulation of the p53-mediated proapoptotic signaling pathway, indicating a potential therapeutic target for cerebral ischemia/reperfusion injury.

8. Histological analysis revealed that there is no apparent structural abnormality of the amygdala and hippocampus, which are regions involved in fear memory consolidation, in Sirt7 KO mice. Our results indicate that SIRT7 is involved in the consolidation of fear memory.

9. Data suggest that high-fat diet (HFD) alters regulation of expression of sirtuins (Sirt4 and Sirt7) and enzymes in NAD biosynthetic pathway (Tdo2 and Nnmt); these alterations are more prominent in liver as compared to white adipose tissue or skeletal muscle; Tdo2 and Nnmt may serve as markers of HFD consumption. (Tdo2 = tryptophan 2,3-dioxygenase; Nnmt = nicotinamide N-methyltransferase)

10. The Sirt7 mediates heterochromatin formation at rRNA genes through recruitment of DNA methyltransferase 1 and another member of the sirtuin family, Sirt1.

11. the decline in SIRT7 in lung fibroblasts has a profibrotic effect, which is mediated by changes in Smad3 levels.

12. SIRT7 inhibits TR4 degradation by deacetylation of DDB1.

13. These results reveal a direct role for SIRT7 in double-strand break repair and establish a functional link between SIRT7-mediated histone H3 K18 deacetylation and the maintenance of genome integrity.

14. miR-93 inhibits the metabolic target Sirt7, which we identified as a major driver of in vivo adipogenesis via induction of differentiation and maturation of early adipocyte precursors.

15. The role of SIRT7 has emerged in protein synthesis, chromatin remodelling, cellular survival and lipid metabolism.

16. SIRT7 stabilizes and activates the GABP alpha/GABPbeta complex via deacetylation of GABPbeta1.

17. SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway.

18. Study identifies SIRT7 as a cofactor of Myc for transcriptional repression and delineates a druggable regulatory branch of the ER stress response that prevents and reverts fatty liver disease.

19. Mybbp1a is a novel negative regulator of Sirt7.

20. SirT7 plays a dominant role in the growth inhibition of the P19 cells.