Sirtuin 7 Proteins (SIRT7)

Human Sirtuin 7 (SIRT7) interaction partners

1. Our study provides evidence that the miR-340/SIRT7 axis may play an important role in the molecular pathogenesis of angiosarcoma.

2. Our data confirmed that SIRT7 was overexpressed in cholangiocarcinoma patient tissues and cell lines.

3. SIRT7 is involved in regulating TGF-beta1-induced ASM cell proliferation.

4. Overexpression of SIRT7 abrogated the effects mediated by miR-519d overexpression in hypertrophic scar fibroblasts.

5. SIRT7-catalysed histone H3 lysine122 desuccinylation is critically implemented in DNA-damage response and cell survival.

6. Knockdown of SIRT7 leads to the same phenotype as depletion of DDX21 (i.e., increased formation of R loops and DNA double-strand breaks), indicating that SIRT7 and DDX21 cooperate to prevent R-loop accumulation, thus safeguarding genome integrity.

7. miR-3666 is an important regulator of breast cancer development. The overexpression of miR-3666 inhibits breast cancer cell proliferation by inhibiting SIRT7.

8. Authors evaluated the expression of known targets of miR-125a and found that sirtuin-7, matrix metalloproteinase-11, and c-Raf were up-regulated in tumor tissue by 2.2-, 3-, and 1.7-fold, respectively. Overall, these data support a tumor suppressor role for miR-125a.

9. We found a negative correlation between mRNA levels of SIRT1 in VAT of obese individuals and SIRT7 in VAT of the normal-weight subjects and expression of the relevant miRNAs.

10. Data indicate the role of SIRT7 in inhibiting SMAD4-mediated breast cancer metastasis providing a possible therapeutic avenue.

11. Energy stress strengthens SIRT7-mediated effects on Akt dephosphorylation.

12. The SIRT7 is mobilized from the nucleolus to the nucleoplasm and promotes DDB1 deacetylation, leading to decreased DDB1-CUL4 association and CRL4 activity.

13. Data suggest that SIRT7 undergoes Lys-63 polyubiquitination, later removed by USP7 to repress enzymatic activity of SIRT7; USP7 and SIRT7 regulate gluconeogenesis via expression of glucose-6-phosphatase catalytic subunit (G6PC); SIRT7 targets G6PC promoter through ELK4. (SIRT7 = sirtuin 7; USP7 = ubiquitin specific peptidase 7; G6PC = glucose-6-phosphatase catalytic subunit; ELK4 = transcription factor ELK4)

14. the decline in SIRT7 in lung fibroblasts has a profibrotic effect, which is mediated by changes in Smad3 levels.

15. SIRT7 inhibits TR4 degradation by deacetylation of DDB1.

16. miR-152/SIRT7 axis plays a key role in the regulation of Human dental pulp stem cell senescence.

17. our study suggests that SIRT7 functions as an oncogene in non-small cell lung cancer (NSCLC), and miR-3666 can target SIRT7 to inhibit NSCLC cell growth by promoting the pro-apoptotic signaling pathway

18. SIRT7 trans-represses RPS7 gene in the presence of HBx protein.HBx enhances intracellular stability of SIRT7 protein.

19. Data indicate that compared to non-neoplastic endometria (NNE), endometrial cancer (EC) showed SIRT7 mRNA overexpression, whereas SIRT1, SIRT2, SIRT4 and SIRT5 were underexpressed, and no significant differences were observed for SIRT3 and SIRT6.

20. This study showed that SIRT7 can be activated by DNA to hydrolyze the acetyl group from lysine residues in vitro on histone peptides and histones in the chromatin context.

Mouse (Murine) Sirtuin 7 (SIRT7) interaction partners

1. The results indicate that miR-148b-3p contributes to the regulation of hypoxia/reoxygenation-induced cardiomyocyte apoptosis in vitro through targeting SIRT7 and modulating p53-mediated pro-apoptotic signaling.

2. SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7.

3. Data indicate that Sirt7 has a slight protective impact on both the adaptive immune system and neurogenesis. However, overall this epigenetic factor is not capable of impacting the acute or chronic phase of neuroinflammation.

4. Loss of SIRT7 is associated with Impairment of Adipogenesis and increased Sirt1 Activity.

5. the results of our study suggest that SIRT7 is involved in protecting neurons against OGD/R-induced injury, possibly through regulation of the p53-mediated proapoptotic signaling pathway, indicating a potential therapeutic target for cerebral ischemia/reperfusion injury.

6. Histological analysis revealed that there is no apparent structural abnormality of the amygdala and hippocampus, which are regions involved in fear memory consolidation, in Sirt7 KO mice. Our results indicate that SIRT7 is involved in the consolidation of fear memory.

7. Data suggest that high-fat diet (HFD) alters regulation of expression of sirtuins (Sirt4 and Sirt7) and enzymes in NAD biosynthetic pathway (Tdo2 and Nnmt); these alterations are more prominent in liver as compared to white adipose tissue or skeletal muscle; Tdo2 and Nnmt may serve as markers of HFD consumption. (Tdo2 = tryptophan 2,3-dioxygenase; Nnmt = nicotinamide N-methyltransferase)

8. The Sirt7 mediates heterochromatin formation at rRNA genes through recruitment of DNA methyltransferase 1 and another member of the sirtuin family, Sirt1.

9. the decline in SIRT7 in lung fibroblasts has a profibrotic effect, which is mediated by changes in Smad3 levels.

10. SIRT7 inhibits TR4 degradation by deacetylation of DDB1.

11. These results reveal a direct role for SIRT7 in double-strand break repair and establish a functional link between SIRT7-mediated histone H3 K18 deacetylation and the maintenance of genome integrity.

12. miR-93 inhibits the metabolic target Sirt7, which we identified as a major driver of in vivo adipogenesis via induction of differentiation and maturation of early adipocyte precursors.

13. The role of SIRT7 has emerged in protein synthesis, chromatin remodelling, cellular survival and lipid metabolism.

14. SIRT7 stabilizes and activates the GABP alpha/GABPbeta complex via deacetylation of GABPbeta1.

15. SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway.

16. Study identifies SIRT7 as a cofactor of Myc for transcriptional repression and delineates a druggable regulatory branch of the ER stress response that prevents and reverts fatty liver disease.

17. Mybbp1a is a novel negative regulator of Sirt7.

18. SirT7 plays a dominant role in the growth inhibition of the P19 cells.

19. SIRT7 is a positive regulator of Pol I transcription and is required for cell viability in mammals.

20. Suggest a critical role of Sirt7 in the regulation of stress responses and cell death in the heart. Enhanced p53 activation by lack of Sirt7-mediated deacetylation contributes to the heart phenotype of Sirt7 mutant mice.