Small Nuclear Ribonucleoprotein 70kDa (U1) Proteins (SNRNP70)

Mediates the splicing of pre-mRNA by binding to the loop I region of U1-snRNA. Additionally we are shipping SNRNP70 Antibodies (43) and SNRNP70 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SNRNP70 20637 Q62376
Rat SNRNP70 SNRNP70 361574  
SNRNP70 6625 P08621
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Top SNRNP70 Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,370.21
Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,370.21
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
$888.80
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 60 to 71 Days
$3,327.50
Details
Escherichia coli (E. coli) Human His tag   1 mg Log in to see 2 to 3 Days
$4,670.77
Details
Human Un-conjugated   20 μg Log in to see 6 Days
$285.21
Details

SNRNP70 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
, ,

More Proteins for Small Nuclear Ribonucleoprotein 70kDa (U1) (SNRNP70) Interaction Partners

Zebrafish Small Nuclear Ribonucleoprotein 70kDa (U1) (SNRNP70) interaction partners

  1. These findings provide evidence for a new role of a general small nuclear ribonucleoprotein particle protein, U1C, as a mediator of alternative splicing regulation.

Mouse (Murine) Small Nuclear Ribonucleoprotein 70kDa (U1) (SNRNP70) interaction partners

  1. This splice-switching class of molecules is the first to specifically correct the ELP1 exon 20 splicing defect. Our data provide proof of principle of ExSpeU1s-adeno-associated virus particles as a novel therapeutic strategy for FD.

Human Small Nuclear Ribonucleoprotein 70kDa (U1) (SNRNP70) interaction partners

  1. These results indicate that the galectin-3-U1 snRNP-pre-mRNA ternary complex is a functional E complex and that U1 snRNP is required to assemble galectin-3 onto an active spliceosome

  2. The epitopes of U1-70K autoantibodies have been mapped at single-amino acid resolution.

  3. The authors propose that Gemin2 is a versatile hub for ribonucleoprotein exchange that functions broadly in RNA metabolism.

  4. data lead to a model that FUS functions in coupling transcription to splicing via mediating an interaction between RNAP II and U1 snRNP

  5. The selection of 5'-splice site nucleotides by U1 snRNP is achieved predominantly through basepairing with U1 snRNA whilst U1-C fine-tunes relative affinities of mismatched 5'-splice sites.

  6. methylation of snRNP70 by SETMAR regulates constitutive and/or alternative splicing

  7. U1-70K interacts with the SMN complex and is required for nuclear gem integrity.

  8. Data indicate that small nuclear ribonucleoprotein U1-70K in Alzheimer disease (AD) may directly sequester normal soluble forms of U1-70K into insoluble aggregates.

  9. [review] The presence of antibodies against U1snRNP autoantigen is considered the serological hallmark of mixed connective tissue disease (MCTD), which is characterized by overlapping features between at least two systemic autoimmune diseases.

  10. These studies identify U1 snRNP pathologic changes in brain of early onset genetic forms of Alzheimer's disease

  11. inhibition of U1 snRNP also leads to regulation of the usage of In3 pA, suggesting that the C/P activity in the cell can be cross-regulated by splicing, leading to coordination between these two processes.

  12. High expression of U1-70K and other U1 small nuclear ribonucleoproteins spliceosome proteins in Alzheimer's disease patients and those with mild cognitive impairment.

  13. Serum antibodies against the 70k polypeptides of the U1 ribonucleoprotein complex are associated with psychiatric syndromes in systemic lupus erythematosus.

  14. U1-snRNP activates the NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome in CD14+ human monocytes dependently of anti-U1-snRNP Abs, leading to interleukin (IL)-1beta production.

  15. data identify some fungal proteins as possible triggers of anti-U1-70 kDa autoimmunity via molecular mimicry.

  16. the hypo-phosphorylated RS domain of SRSF1 interacts with its own RRM, thus competing with U1-70K binding, whereas the hyper-phosphorylated RS domain permits the formation of a ternary complex containing ESE, an SR protein, and U1 snRNP

  17. Recruitment of RNAPII, U1-70K and ASF/SF2 protein to transcription sites is splicing independent.

  18. crucial association of B19-NS1 in development of autoimmunity by inducing apoptosis and specific cleavage of 70 kDa U1-snRNP

  19. U1-70k isoforms control subunit dynamics in the human spliceosomal U1 snRNP

SNRNP70 Protein Profile

Protein Summary

Mediates the splicing of pre-mRNA by binding to the loop I region of U1-snRNA. The truncated isoforms cannot bind U1-snRNA.

Gene names and symbols associated with SNRNP70

  • small nuclear ribonucleoprotein, U1 70kDa subunit (snrnp70)
  • small nuclear ribonucleoprotein U1 subunit 70 (SNRNP70)
  • small nuclear ribonucleoprotein 70 (U1) (snrnp70)
  • small nuclear ribonucleoprotein 70 (U1) (Snrnp70)
  • small nuclear ribonucleoprotein U1 subunit 70 (Snrnp70)
  • small nuclear ribonucleoprotein, U1 70kDa subunit L homeolog (snrnp70.L)
  • 70kDa protein
  • 2700022N21Rik protein
  • 3200002N22Rik protein
  • AI325098 protein
  • R74807 protein
  • RNPU1Z protein
  • Rnulp70 protein
  • RPU1 protein
  • Snp1 protein
  • Snrp70 protein
  • Srnp70 protein
  • U1-70 protein
  • U1-70K protein
  • U1AP protein
  • U1RNP protein
  • U170K protein
  • wu:fc20b04 protein
  • zgc:136450 protein

Protein level used designations for SNRNP70

U1 small nuclear ribonucleoprotein 70 kDa , U1 snRNP 70 kDa , U1-70K , small nuclear ribonucleoprotein 70kDa polypeptide (RNP antigen) , small nuclear ribonucleoprotein 70kDa (U1) , U1 small nuclear ribonucleoprotein polypeptide A , U1 small ribonucleoprotein 70kd , small nuclear ribonucleoprotein 70kDa , U1 small nuclear ribonucleoprotein 70 kDa polypeptide A

GENE ID SPECIES
493488 Xenopus (Silurana) tropicalis
747202 Pan troglodytes
100595176 Nomascus leucogenys
445398 Danio rerio
20637 Mus musculus
361574 Rattus norvegicus
397946 Xenopus laevis
6625 Homo sapiens
484388 Canis lupus familiaris
535113 Bos taurus
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