SMG7 Proteins
SMG7 encodes a protein that is essential for nonsense-mediated mRNA decay (NMD)\; a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex.
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Smg-7 Homolog, Nonsense Mediated mRNA Decay Factor (C. Elegans) (SMG7) (AA 2-1138) protein (His tag) Protein
Smg-7 Homolog, Nonsense Mediated mRNA Decay Factor (C. Elegans) (SMG7) (AA 2-1137) protein (His tag) Protein
Smg-7 Homolog, Nonsense Mediated mRNA Decay Factor (C. Elegans) (SMG7) (AA 19-550), (partial) Protein Protein
Smg-7 Homolog, Nonsense Mediated mRNA Decay Factor (C. Elegans) (SMG7) (AA 19-550), (partial) protein (His tag) Protein
SMG7 Protein Profile
Protein Summary
This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD)\; a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Gene names and symbols associated with SMG7
- Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans) (Smg7) antibody
- SMG7, nonsense mediated mRNA decay factor (SMG7) antibody
- 9430023P16Rik antibody
- C1orf16 antibody
- EST1C antibody
- mKIAA0250 antibody
- SGA56M antibody
Protein level used designations for SMG7
EST1-like protein C , protein SMG7 , EST1 telomerase component homolog C , breast cancer-associated antigen SGA-56M , ever shorter telomeres 1C , smg-7 homolog, nonsense mediated mRNA decay factor
| GENE ID | SPECIES |
|---|---|
| 226517 | Mus musculus |
| 9887 | Homo sapiens |
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