anti-SMCR8 Antibodies

Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy.

Data Quality
  • 3
Type
  • 4
    Primary antibodies
Antigen
  • 4
Reactivity
  • 4
  • 1
  • 1
  • 1
  • 1
Application
  • 3
  • 2
  • 2
Host
  • 4
Clonality
  • 4
Binding Specificity
  • 1
  • 1
Isotype
  • 2
Format
  • 3
  • 1
4 Products
ReactivityHuman
Application IF, IHC (p), WB
Order details Cat. No. ABIN5588427
$577.33
100 μL
Plus shipping costs $45.00
Delivery in 11 to 12 Business Days
ReactivityHuman
Application IF, IHC (p)
Order details Cat. No. ABIN5588428
$577.33
100 μL
Plus shipping costs $45.00
Delivery in 11 to 12 Business Days
ReactivityDog (Canine), Horse (Equine), Human, Rabbit, Rat (Rattus)
Application WB
Order details Cat. No. ABIN2791916
$229.00
100 μL
Plus shipping costs $45.00
Delivery in 2 to 3 Business Days
ReactivityHuman
Application WB
Order details Cat. No. ABIN6753676
$551.83
100 μL
Plus shipping costs $45.00
Delivery in 11 to 14 Business Days
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SMCR8 Antigen Profile

Protein Summary

Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity. {ECO:0000250|UniProtKB:Q8TEV9}.

Gene names and symbols associated with SMCR8

  • Smith-Magenis syndrome chromosome region, candidate 8 (SMCR8) antibody
  • Smith-Magenis syndrome chromosome region, candidate 8 homolog (human) (Smcr8) antibody
  • Smith-Magenis syndrome chromosome region, candidate 8 (Smcr8) antibody
  • Smith-Magenis syndrome chromosome region, candidate 8b (smcr8b) antibody
  • 2310076G09Rik antibody
  • AI642055 antibody
  • D030073L15Rik antibody
  • RGD1564621 antibody
  • smcr8 antibody

Protein level used designations for SMCR8

Smith-Magenis syndrome chromosomal region candidate gene 8 protein , Smith-Magenis syndrome chromosomal region candidate gene 8 protein homolog , Smith-Magenis syndrome chromosome region, candidate 8 homolog , Smith-Magenis syndrome chromosomal region candidate gene 8 protein homolog B , guanine nucleotide exchange protein smcr8b , smith-Magenis syndrome chromosomal region candidate gene 8-B protein homolog

GENE ID SPECIES
140775 Homo sapiens
237782 Mus musculus
497918 Rattus norvegicus
407723 Danio rerio
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