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anti-SMCR8 Antibodies

Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy.

3 results:

anti-SMCR8 antibody (Smith-Magenis Syndrome Chromosome Region, Candidate 8) Primary Antibody

SMCR8 Reactivity: Human IF, IHC (p), WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN5588427
$737.33
Plus shipping costs $45.00
100 μL
local_shipping Shipping to: United States
Delivery in 11 to 12 Business Days

anti-SMCR8 antibody (Smith-Magenis Syndrome Chromosome Region, Candidate 8) (C-Term) Primary Antibody

SMCR8 Reactivity: Human, Rat, Dog, Horse, Rabbit WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2791916
$389.00
Plus shipping costs $45.00
100 μL
local_shipping Shipping to: United States
Delivery in 2 to 3 Business Days

anti-SMCR8 antibody (Smith-Magenis Syndrome Chromosome Region, Candidate 8) (AA 841-890) Primary Antibody

SMCR8 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6753676
$597.30
Plus shipping costs $45.00
100 μL
local_shipping Shipping to: United States
Delivery in 11 to 14 Business Days
  • Type Primary
    • Primary
  • Target Smith-Magenis Syndrome Chromosome Region, Candidate 8 (SMCR8)
    • Smith-Magenis Syndrome Chromosome Region, Candidate 8 (SMCR8)
    • Histone 3 (H3)
    • Tumor Protein P53 (TP53)
    • Epidermal Growth Factor Receptor (EGFR)
    • Mast/stem Cell Growth Factor Receptor (KIT)
    • Protein tyrosine Phosphatase, Receptor Type, C (PTPRC)
    • tau Protein
    • CD4 Molecule (CD4)
    • Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2)
    • Tumor Necrosis Factor alpha (TNF)
    • V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1)
    • Interferon gamma (IFNG)
    • Nuclear Factor-KB P65 (NFkBP65)
    • Estrogen Receptor 1 (ESR1)
    • Albumin (ALB)
    • BCL2-Associated Agonist of Cell Death (BAD)
    • B-Cell CLL/lymphoma 2 (BCL2)
    • V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1)
    • Platelet/endothelial Cell Adhesion Molecule (PECAM1)
    • Tuberous Sclerosis 2 (TSC2)
    • CD19 Molecule (CD19)
    • CD8a Molecule (CD8A)
    • Hemagglutinin (HA)
    • CD3e Molecule, epsilon (CD3-TCR Complex) (CD3E)
    • Integrin alpha M (ITGAM)
    • Interleukin 6 (IL6)
    • CD8
    • Histone H4
    • CD44
    • Jun Proto-Oncogene (JUN)
    • Epithelial Cell Adhesion Molecule (EPCAM)
    • Myc Proto-Oncogene protein (MYC)
    • Catenin, beta
    • Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1 (RPS6KB1)
    • Interleukin 2 Receptor, alpha (IL2RA)
    • PTK2 Protein tyrosine Kinase 2 (PTK2)
    • Vimentin (VIM)
    • Mucin 1, Cell Surface Associated (MUC1)
    • CD5 Molecule (CD5)
    • Interleukin 2 (IL2)
    • Amyloid beta (A4) Precursor Protein (APP)
    • Glial Fibrillary Acidic Protein (GFAP)
    • Membrane-Spanning 4-Domains, Subfamily A, Member 1 (MS4A1)
    • CD3
    • Insulin Receptor Substrate 1 (IRS1)
    • CD34
    • C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1)
    • Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR)
    • Keratin 18 (KRT18)
    • CD14
    • Synuclein, alpha (SNCA)
  • Application
    • Western Blotting (WB)
    • Immunofluorescence (IF)
    • Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • Reactivity
    • Human
    • Dog
    • Horse
    • Rabbit
    • Rat
  • Images available
  • Host
    • Rabbit
  • Clonality
    • Polyclonal
  • Binding Specificity
    • AA 841-890
    • C-Term
  • Isotype
    • IgG
  • Format
    • Liquid
    • Lyophilized

SMCR8 Antigen Profile

Protein Summary

Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity. {ECO:0000250|UniProtKB:Q8TEV9}.

Gene names and symbols associated with SMCR8

  • Smith-Magenis syndrome chromosome region, candidate 8 (SMCR8) antibody
  • Smith-Magenis syndrome chromosome region, candidate 8 homolog (human) (Smcr8) antibody
  • Smith-Magenis syndrome chromosome region, candidate 8 (Smcr8) antibody
  • Smith-Magenis syndrome chromosome region, candidate 8b (smcr8b) antibody
  • 2310076G09Rik antibody
  • AI642055 antibody
  • D030073L15Rik antibody
  • RGD1564621 antibody
  • smcr8 antibody

Protein level used designations for SMCR8

Smith-Magenis syndrome chromosomal region candidate gene 8 protein , Smith-Magenis syndrome chromosomal region candidate gene 8 protein homolog , Smith-Magenis syndrome chromosome region, candidate 8 homolog , Smith-Magenis syndrome chromosomal region candidate gene 8 protein homolog B , guanine nucleotide exchange protein smcr8b , smith-Magenis syndrome chromosomal region candidate gene 8-B protein homolog

GENE ID SPECIES
140775 Homo sapiens
237782 Mus musculus
497918 Rattus norvegicus
407723 Danio rerio

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