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SMCR8 Products

(Smith-Magenis Syndrome Chromosome Region, Candidate 8 (SMCR8))

Categories

Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity. {ECO:0000250|UniProtKB:Q8TEV9}.

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Featured SMCR8 Categories

SMCR8 Antibodies

High quality antibodies with extensive validation data.

Recommended SMCR8 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Application ELISA
Validations
Cat. No. ABIN7095499
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IP
Validations
Cat. No. ABIN7452051
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB
Validations
Cat. No. ABIN6753676
Quantity 100 μL
Datasheet Datasheet

Recommended SMCR8 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3076918
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3122079
Quantity 1 mg
Datasheet Datasheet

Synonyms and alternative names related to SMCR8

Smith-Magenis syndrome chromosome region, candidate 8 (SMCR8), Smith-Magenis syndrome chromosome region, candidate 8 homolog (human) (Smcr8), Smith-Magenis syndrome chromosome region, candidate 8 (Smcr8), Smith-Magenis syndrome chromosome region, candidate 8b (smcr8b), 2310076G09Rik, AI642055, D030073L15Rik, RGD1564621, smcr8

Protein level used designations for SMCR8

  • Smith-Magenis syndrome chromosomal region candidate gene 8 protein
  • Smith-Magenis syndrome chromosomal region candidate gene 8 protein homolog
  • Smith-Magenis syndrome chromosome region, candidate 8 homolog
  • Smith-Magenis syndrome chromosomal region candidate gene 8 protein homolog B
  • guanine nucleotide exchange protein smcr8b
  • smith-Magenis syndrome chromosomal region candidate gene 8-B protein homolog
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