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SMTN encodes a structural protein that is found exclusively in contractile smooth muscle cells.
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Human Monoclonal Smoothelin Primary Antibody for IHC (fro), IHC (p) - ABIN335397
Christen, Bochaton-Piallat, Neuville, Rensen, Redard, van Eys, Gabbiani: Cultured porcine coronary artery smooth muscle cells. A new model with advanced differentiation. in Circulation research 1999
Show all 9 Pubmed References
Smoothelin is a specific marker for smooth muscle cells with contractile capacity which has not been widely studied in glomus lesions. in this study, glomic cells showed cytoplasmic positivity for smoothelin. Smoothelin expression in glomic cells indicates that they are contractile smooth muscle cells, and thus its role in routine diagnosis should be considered.
Caldesmon (show CALD1 Antibodies) and smoothelin staining allows better delineation of the muscularis propria from the desmoplastic stromal reaction which provides a critical aide for proper staging of colonic adenocarcinomas.
During development of advanced liver fibrosis, a subpopulation of myofibroblasts expressing smoothelin may be derived from vascular smooth muscle cells.
The objective of the following study was to record the specificity and sensitivity of alpha5(IV) loss, smoothelin expression and PLAP (show ALP Antibodies) expression as markers of gastrointestinal smooth muscle neoplasms
There is an association between essential hypertension and the SMTN gene.
Phenotypic expression of alpha-smooth muscle actin (show ACTG2 Antibodies), smooth muscle myosin heavy chain (show MYH11 Antibodies) 2 (show MYH2 Antibodies), and smoothelin were significantly decreased in the dissected media, whereas that of osteopontin (show SPP1 Antibodies) was elevated.
Smoothelin haplotype constructed using rs5997872, rs56095120, rs9621187 and rs10304 was a useful genetic marker of cerebral infarction in Japanese men.
Smoothelin immunoreactivity in bladder diverticula confirms limited nature of smoothelin expression in muscularis mucosae and represents useful ancillary technique in proper histopathologic evaluation of diverticular and nondiverticular bladder carcinoma
We report the first study of smoothelin expression in normal skin
Immunohistochemistry for smoothelin identifies differential staining between the neomuscularis mucosa and the true muscularis mucosa in Barrett's esophagus.
Smoothelin-A is essential for functional contractility of intestinal smooth muscle.
This gene encodes a structural protein that is found exclusively in contractile smooth muscle cells. It associates with stress fibers and constitutes part of the cytoskeleton. This gene is localized to chromosome 22q12.3, distal to the TUPLE1 locus and outside the DiGeorge syndrome deletion. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
, smoothelin b