anti-Sodium Channel, Voltage-Gated, Type I, alpha Subunit (SCN1A) Antibodies

The vertebrate sodium channel is a voltage-gated ion channel essential for the generation and propagation of action potentials, mainly in nerve and muscle. Additionally we are shipping Sodium Channel, Voltage-Gated, Type I, alpha Subunit Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SCN1A 20265  
SCN1A 81574 P04774
SCN1A 6323 P35498
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Top anti-Sodium Channel, Voltage-Gated, Type I, alpha Subunit Antibodies at antibodies-online.com

Showing 10 out of 46 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Mammalian Mouse Un-conjugated ISt, IHC, WB   5 mL Log in to see 2 to 6 Days
$394.53
Details
Human Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of Nav1.1 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of Nav1.1 expression in SHSY5Y (A), mouse brain (B), PC12 (C) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of Scn1a expression in rat brain extract (lane 1), mouse brain extract (lane 2) and U87 whole cell lysates (lane 4). Scn1a at 250KD was detected using rabbit anti- Scn1a Antigen Affinity purified polyclonal antibody at0.5 μg/mL. The blot was developed using chemiluminescence (ECL) method 100 μg Log in to see 4 to 6 Days
$240.00
Details
Bat Rabbit Un-conjugated IHC, IHC (p) Anti-SCN1A / Nav1.1 antibody  ABIN1049319 IHC staining of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-SCN1A / Nav1.1 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Anti-SCN1A / Nav1.1 antibody IHC staining of human pancreas, exocrine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN1104128 concentration 20 ug/ml. Anti-SCN1A / Nav1.1 antibody IHC of human pancreas, exocrine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml. 100 μL Log in to see 11 to 14 Days
$727.83
Details
Rat Mouse HRP IHC, IP, WB Immunohistochemical staining of frozen sections of mouse brain extract with Scn1a monoclonal antibody, clone S74-71. 100 μg Log in to see 11 to 12 Days
$577.33
Details
Rat Mouse Atto 594,PE IHC, IP, WB Immunohistochemical staining of frozen sections of mouse brain extract with Scn1a monoclonal antibody, clone S74-71. 100 μg Log in to see 11 to 12 Days
$577.33
Details
Rat Mouse PerCP IHC, IP, WB Immunohistochemical staining of frozen sections of mouse brain extract with Scn1a monoclonal antibody, clone S74-71. 100 μg Log in to see 11 to 12 Days
$577.33
Details
Rat Mouse PE IHC, IP, WB Immunohistochemical staining of frozen sections of mouse brain extract with Scn1a monoclonal antibody, clone S74-71. 100 μg Log in to see 11 to 12 Days
$577.33
Details
Rat Mouse Streptavidin IHC, IP, WB Immunohistochemical staining of frozen sections of mouse brain extract with Scn1a monoclonal antibody, clone S74-71. 100 μg Log in to see 11 to 12 Days
$577.33
Details

Top referenced anti-Sodium Channel, Voltage-Gated, Type I, alpha Subunit Antibodies

  1. Mammalian Monoclonal SCN1A Primary Antibody for ISt, IHC - ABIN1304837 : Tian, Wang, Ke, Guo, Shu: Molecular identity of axonal sodium channels in human cortical pyramidal cells. in Frontiers in cellular neuroscience 2014 (PubMed)
    Show all 31 Pubmed References

More Antibodies against Sodium Channel, Voltage-Gated, Type I, alpha Subunit Interaction Partners

Mouse (Murine) Sodium Channel, Voltage-Gated, Type I, alpha Subunit (SCN1A) interaction partners

  1. these data suggest that MDH2, functioning as an RNA-binding protein, is involved in the posttranscriptional downregulation of SCN1A expression under seizure condition.

  2. Rer1 controls the assembly and transport of Nav1.1 and 1.6, the principal sodium channels responsible for recurrent firing, in Purkinje cells.

  3. selective activation of NaV1.1 by venom peptide Hm1a restores the function of inhibitory interneurons from Dravet syndrome mice without affecting the firing of excitatory neurons.

  4. Scn1a was mapped to the QTL for febrile seizure susceptibility.

  5. results therefore indicate that, while Nav1.1 is expressed in MEG-derived inhibitory neurons, Nav1.2 is expressed in caudal ganglionic eminence-derived disinhibitory interneurons in addition to excitatory neurons

  6. Pharmological manipulation by clobazam, a common anticonvulsant with preferential affinity for the GABRA2 receptor, revealed dose-dependent protection against hyperthermia-induced seizures in Scn1a+/- mice. These findings support Gabra2 as a genetic modifier of the Scn1a+/- mouse model of Dravet syndrome.

  7. In this study, we characterized the behavior of heterozygous mice expressing the SCN1A R1648H mutation (Scn1a(RH/+)) and the effect of stress on spontaneous and induced seizures. We also examined the effect of the R1648H mutation on the hypothalamic-pituitary-adrenal (HPA) axis response.

  8. findings establish an unexpected role for Nav1.1 channels in regulating the excitability of sensory nerve fibres that mediate mechanical pain

  9. Deletion of Nav1.1 channels selectively impairs excitability of GABAergic interneurons

  10. the time course of declining expression of the murine embryonic sodium channel Nav 1.3 and the rise in expression of the adult sodium channel Nav 1.1 with susceptibility to epileptic seizures and increased incidence of sudden death

  11. Results show Nav1.1 haploinsufficiency in excitatory neurons has an ameliorating effect on the pathology of Dravet syndrome.

  12. These data indicate that a disease-causing central nervous system voltage-gated sodium channel mutation confers susceptibility to the proconvulsant, but not motoric, effects of cocaine.

  13. These results establish a direct role for SCN1A in the regulation of sleep

  14. Loss of NaV1.1 channels in forebrain GABAergic neurons is both necessary and sufficient to cause epilepsy and premature death in Dravet syndrome.

  15. mice with Scn1a haploinsufficiency exhibit hyperactivity, stereotyped behaviours, social interaction deficits and impaired context-dependent spatial memory; results demonstrate a critical role for Na(V)1.1 channels in neuropsychiatric functions and provide a potential therapeutic strategy for cognitive deficit and autism-spectrum behaviours in Dravet's syndrome

  16. These results demonstrate increased expression levels of Nav1.7, Nav1.8, and perhaps Nav1.1 in the dorsal root ganglia in mice with a heterozygous mutation of the Nf1 gene

  17. Na(V)1.1 channels are expressed in the suprachiasmatic nucleus (SCN) of the hypothalamus.

  18. a mechanism consistent with BACE1 activity regulating mRNA levels of the alpha-subunit Na(v)1.1 via cleavage of cell-surface Na(v)beta(2).

  19. We describe a Roma/Gypsy family, where a missense mutation in SCN1A, p.D194N, is transmitted from a mosaic GEFS+ father to a child with Dravet syndrome.

  20. SCN1A voltage-gated sodium channel has a role in gamma-aminobutyric acid-ergic (GABAergic) interneuron abnormalities

Human Sodium Channel, Voltage-Gated, Type I, alpha Subunit (SCN1A) interaction partners

  1. De novo mutations in SCN1A found in two unrelated patients are associated with classic Rett syndrome.

  2. five of these variants promote inclusion of a "poison" exon that leads to reduced amounts of full-length SCN1A protein.

  3. The present study demonstrated for the first time that a significant decrease of cerebral glucose metabolism occurred in the fronto-temporo-parietal and occipital cortices along with aging in patients with DS and a SCN1A variant.

  4. Study represents the first evidence of the abnormal changes in voltage-gated sodium channels subtypes (including Nav1.1) and CaM/CaMKII pathway in human brain low-grade astrocytoma, providing new potential targets for molecular therapies of this disease.

  5. This study reinforces the importance of somatic mosaicism caused by copy number variations in disease-causing genes, and provides an alternative spectrum of SCN1A mutations causative of DS. Somatic deletions in SCN1A should be considered in cases with DS when standard screenings for SCN1A mutations are apparently negative for mutations.

  6. The results of this study suggested that SCN1A rs3812718 polymorphism is associated with the risk of epilepsy.

  7. Findings support understanding and updating knowledge on the correlation between phenotype distribution and location and type of mutations in SCN1A-related disorders

  8. In 13 Han Chinese pedigrees clinically diagnosed with Dravet syndrome, 11 variants were identified in SCN1A gene among 11 pedigrees including 7 missense mutations, 2 splice site mutations, and 2 frameshift mutations (9 novel variants and 2 reported mutations). Particularly, 2 of these Dravet syndrome patients with SCN1A variants also harbored SCN9A, KCNQ2, or SLC6A8 variants.

  9. Our cases represent a novel association between SCN1A and sudden infant death syndrome (SIDS), extending the SCN1A spectrum from epilepsy to SIDS.

  10. The effect of Ca(2+), domain-specificity, and CaMKII on CaM binding to NaV1.1 has been reported.

  11. This first genetic study of Dravet syndrome in Africa confirms that de novo SCN1A variants underlie disease in the majority of South African patients.

  12. these data suggest that MDH2, functioning as an RNA-binding protein, is involved in the posttranscriptional downregulation of SCN1A expression under seizure condition.

  13. Postzygotic mutation is a common phenomenon in SCN1A-related epilepsies. Participants with mosaicism have on average milder phenotypes, suggesting that mosaicism can be a major modifier of SCN1A-related diseases.

  14. SCN1A and SCN2A mutations and clinical/EEG features in Chinese patients from epilepsy or severe seizures

  15. rs7668282 (UGT2B7, T>C) was more prevalent in sodium valproate (VPA)-resistant patients than drug-responsive patients. rs2242480 (CYP3A4, C>T) and rs10188577 (SCN1A, T>C) were more prevalent in drug-responsive patients compared to drug-resistant patients. In children with generalized seizures on VPA therapy, polymorphisms of UGT2B7, CYP3A4, and SCN1A genes were associated with seizure reduction.

  16. Meta-analysis indicates that the A-allele of SCN1A rs2298771 polymorphism, especially AA genotype, may play an important role in responsiveness to sodium channel blocking antiepileptic drugs, while SCN1A rs3812718 polymorphism is not associated.

  17. Study established induced pluripotent stem cells (iPSC)from two Dravet syndrome patients with different mutations in SCN1A and subsequently differentiated them into forebrain GABAergic neurons. Unique genetic alterations of SCN1A differentially impacted electrophysiological impairment of the neurons, and the impairment's extent corresponded with the symptomatic severity of the donor from which the iPSCs were derived.

  18. miR155 may be associated with the risk of seizure and SCN1A may be a target gene of miR155.

  19. we report a Chinese familial hemiplegic migraine type 3 family with a novel mutation in the SCN1A gene.

  20. The polymorphic SCN1A c.3184A>G/p.Thr1067Ala G allele was associated with a lower risk of epilepsy and a higher remission rate in Slovenian children and adolescents with epilepsy.

Sodium Channel, Voltage-Gated, Type I, alpha Subunit (SCN1A) Antigen Profile

Protein Summary

The vertebrate sodium channel is a voltage-gated ion channel essential for the generation and propagation of action potentials, mainly in nerve and muscle. Voltage-sensitive sodium channels are heteromeric complexes consisting of a large central pore-forming glycosylated alpha subunit, and two smaller auxiliary beta subunits. This gene encodes the large alpha subunit, and mutations in this gene have been associated with several epilepsy, convulsion and migraine disorders. Alternative splicing results in multiple transcript variants. The RefSeq Project has decided to create four representative RefSeq records. Three of the transcript variants are supported by experimental evidence and the fourth contains alternate 5' untranslated exons, the exact combination of which have not been experimentally confirmed for the full-length transcript.

Gene names and symbols associated with SCN1A

  • sodium voltage-gated channel alpha subunit 1 (SCN1A) antibody
  • sodium voltage-gated channel alpha subunit 9 (SCN9A) antibody
  • sodium channel, voltage-gated, type I, alpha (Scn1a) antibody
  • sodium voltage-gated channel alpha subunit 1 (Scn1a) antibody
  • B230332M13 antibody
  • EIEE6 antibody
  • FEB3 antibody
  • FEB3A antibody
  • FHM3 antibody
  • GEFSP2 antibody
  • HBSCI antibody
  • NAC1 antibody
  • Nav1.1 antibody
  • SCN1 antibody
  • SCN1A antibody
  • SCN9A antibody
  • SMEI antibody

Protein level used designations for SCN1A

sodium channel, voltage-gated, type IX, alpha subunit , voltage-gated sodium channel I , sodium channel, voltage-gated, type I, alpha subunit , sodium channel protein brain I subunit alpha , sodium channel protein type 1 subunit alpha , sodium channel protein type I subunit alpha , sodium channel protein, brain I subunit alpha , sodium channel voltage-gated type I alpha polypeptide , sodium channel, voltage-gated, type 1, alpha polypeptide , sodium channel, voltage-gated, type I, alpha polypeptide , voltage-gated sodium channel subunit alpha Nav1.1 , sodium channel protein, brain I alpha subunit , sodium channel voltage gated type 1 alpha subunit , sodium channel voltage-gated type I alpha

GENE ID SPECIES
100052059 Equus caballus
395946 Gallus gallus
20265 Mus musculus
81574 Rattus norvegicus
6323 Homo sapiens
478775 Canis lupus familiaris
529590 Bos taurus
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