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forms a voltage gated sodium channel with alpha subunit\; may modulate sodium channel expression in neurons [RGD, Feb 2006].. Additionally we are shipping SCN2B Antibodies (121) and SCN2B Proteins (10) and many more products for this protein.
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Findings add to the understanding of beta2 role in Nav 1.5 trafficking and localisation, which must influence cell excitability and electrical coupling in the heart.
The authors identified a flexible loop formed by (72)Cys and (75)Cys, a unique feature among the four beta-subunit isoforms.
Contribution of Cardiac Sodium Channel beta-Subunit Variants to Brugada Syndrome.
In a nonreferred nationwide Danish cohort of SIDS cases, up to 5/66 (7.5%) of SIDS cases can be explained by genetic variants in the sodium channel complex genes.
With increased beta-2 expression, prostate cancer cells display a trend of enhanced association with nerve axons.
sodium channel polymorphisms are associated with epilepsy
SCN2B is a new candidate gene associated with Brugada syndrome.
beta2 is a PS/gamma-secretase substrate, gamma-secretase mediated cleavage of beta2-C-terminal fragment is required for cell-cell adhesion and migration of beta2-expressing cells
Genetic deletion of Scn2b in mice results in ventricular and atrial arrhythmias, consistent with reported SCN2B mutations in human patients.
SCN2B could play an important role in the aging-related cognitive deterioration, which is associated with the regulations of COX5A and FGF-2.
This study demonistrated that scn2b gene expression in mouse dorsal raphe nucleus
Increased beta2 subunit expression in sensory neurons after nerve injury is functionally significant. Development of mechanical allodynia-like behavior in the SNI model is attenuated in beta2 subunit null mutant mice.
Data suggest that loss of sodium channel beta2 subunit is neuroprotective in experimental allergic encephalomyelitis by prevention of Na+ channel up-regulation in response to demyelination.
forms a voltage gated sodium channel with alpha subunit\; may modulate sodium channel expression in neurons
neuronal voltage-gated sodium channel beta 2 subunit
, sodium channel beta 2 subunit
, sodium channel subunit beta-2
, sodium channel, voltage-gated, type II, beta polypeptide
, Sodium channel beta 2
, cardiomyocyte sodium channel beta-2 subunit
, sodium channel, voltage-gated, type II, beta
, sodium voltage-gated channel type II beta
, voltage-gated sodium channel beta 2 subunit