Protein Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease.

Gene names and symbols associated with sTNF-R1

• TNF receptor superfamily member 1A (TNFRSF1A) antibody

• CD120a antibody
• FPF antibody
• MS5 antibody
• p55 antibody
• p55-R antibody
• Show all synonym aliases
• p60 antibody
• TBP1 antibody
• TNF-R antibody
• TNF-R-I antibody
• TNF-R55 antibody
• TNFAR antibody
• TNFR1 antibody
• TNFR1-d2 antibody
• TNFR55 antibody
• TNFR60 antibody

Protein level used designations for sTNF-R1

TNF-R1 , TNF-RI , TNFR-I , tumor necrosis factor binding protein 1 , tumor necrosis factor receptor 1A isoform beta , tumor necrosis factor receptor superfamily member 1A , tumor necrosis factor receptor type 1 , tumor necrosis factor-alpha receptor