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The protein encoded by SLC16A1 is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Additionally we are shipping SLC16A1 Kits (23) and SLC16A1 Proteins (4) and many more products for this protein.
Showing 10 out of 77 products:
Human Polyclonal SLC16A1 Primary Antibody for WB - ABIN2781585
Borthakur, Gill, Hodges, Ramaswamy, Hecht, Dudeja: Enteropathogenic Escherichia coli inhibits butyrate uptake in Caco-2 cells by altering the apical membrane MCT1 level. in American journal of physiology. Gastrointestinal and liver physiology 2005
The suppression of NHE1 (show SLC9A1 Antibodies) in esophageal squamous cell carcinoma (ESCC) may enhance malignant potential by mediating PI3K (show PIK3CA Antibodies)-AKT (show AKT1 Antibodies) signaling and epithelial-mesenchymal transition via Notch (show NOTCH1 Antibodies) signaling, and may be related to a poor prognosis in patients with ESCC.
Genetic disruption of the intracellular pH-regulating proteins Na+/H+ exchanger 1 (SLC9A1 (show SLC9A1 Antibodies)) and carbonic anhydrase 9 (show CA9 Antibodies) reduces the proliferation of colon cancer cells.
Hypoxia-induced MCT1 (show CMA1 Antibodies) supports glioblastoma glycolytic phenotype, being responsible for lactate efflux and an important mediator of cell survival and aggressiveness
NHE1 (show SLC9A1 Antibodies) mutation is associated with metastatic potential and epithelial-mesenchymal transition of triple-negative breast cancer.
our finding that the expression of MCT1 (show CMA1 Antibodies) and MCT4 (show SLC16A4 Antibodies) is reduced in mutant IDH1 (show IDH1 Antibodies) gliomas highlights the unusual metabolic reprogramming that occurs in mutant IDH1 (show IDH1 Antibodies) tumors and has important implications for our understanding of these tumors and their treatment
The expression pattern of sNHE (show SLC9C1 Antibodies) suggested that this protein may be involved in the regulation of sperm motility, and aberration of its expression in sperm may contribute to the pathogenesis of asthenozoospermia.
MCT1 (show CMA1 Antibodies) expression, independent of transporter activity, is required for growth factor-induced tumor cell motility.
TOMM20 (show TOMM20 Antibodies), MCT1 (show CMA1 Antibodies), and MCT4 (show SLC16A4 Antibodies) expression was significantly different in Hodgkin and Reed Sternberg (HRS) cells. HRS have high expression of MCT1 (show CMA1 Antibodies), while tumor associated macrophages have absent MCT1 (show CMA1 Antibodies) expression. Tumor-infiltrating lymphocytes have absent MCT1 (show CMA1 Antibodies) expression. Reactive lymph nodes in contrast to cHL (show CHRDL1 Antibodies) tumors had low TOMM20 (show TOMM20 Antibodies), MCT1 (show CMA1 Antibodies), and MCT4 (show SLC16A4 Antibodies) expression in lymphocytes and macrophages.
TOMM20 (show TOMM20 Antibodies) and MCT1 (show CMA1 Antibodies) were highly expressed in diffuse large B-cell lymphoma lymphocytes, indicating an OXPHOS phenotype, whereas non-neoplastic lymphocytes in the control samples did not express these markers.
Data show for the first time that PRLR (show PRLR Antibodies) activation stimulates breast cancer cell invasiveness via the activation of NHE1 (show SLC9A1 Antibodies). Data propose that PRL (show PRL Antibodies)-induced NHE1 (show SLC9A1 Antibodies) activation and the resulting NHE1 (show SLC9A1 Antibodies)-dependent invasiveness may contribute to the metastatic behavior of human breast cancer cells.
Data indicate that monocarboxylate transporters (MCTs1 (show MCTS1 Antibodies)-4) were all found to be expressed in brains of embryos, and were localized in both neurons and astrocyte.
The expression of monocarboxylic acid transporter 1 (MCT1 (show MCTS1 Antibodies)), MCT2 (show SLC16A7 Antibodies), and CD147 in 3 horse breeds with different atheletic demands is reported.[MCT1 (show MCTS1 Antibodies); MCT2 (show SLC16A7 Antibodies)]
Results indicated that a single IET resulted in transient increases in MCT1 (show MCTS1 Antibodies) and MCT4 (show SLC16A3 Antibodies) mRNA expression and protein content in untrained and trained horses.
The coding sequence of MCT1 (show MCTS1 Antibodies), MCT4 (show SLC16A3 Antibodies), and CD147 in healthy horses, and the incidence of polymorphisms of these proteins in horses with excercise-induced myopathy are reported.
MCT1 (show MCTS1 Antibodies) protein content in GMM samples obtained when the horses were 24 months old was significantly higher than at 2 months of age. However, MCT4 (show SLC16A3 Antibodies) protein content remained unchanged throughout the study period.
Silencing or genetic deletion of MCT1 (show MCTS1 Antibodies) in vivo inhibited migration, invasion, and spontaneous metastasis.
It was concluded that both MCT1 (show MCTS1 Antibodies) and CAII (show CA2 Antibodies) are involved in the homeostatic control of pH in skeletal muscle, both at rest and at the onset of exercise. The improved muscle function and resistance to fatigue in MCT1 (show MCTS1 Antibodies)(+/-) mice remain unexplained.
Exercise-induced changes in tumour LDH-B (show LDHB Antibodies) and MCT1 (show MCTS1 Antibodies) expression are modulated by oestrogen-related receptor alpha in breast cancer-bearing BALB/c mice
Chronic lactate administration after exercise increases MCT1 (show MCTS1 Antibodies) protein expression, which can be involved in the regulation of the observed increase in muscle glycogen (show GYS1 Antibodies) storage after exercise training.
This study showed that mouse MCT1 (show MCTS1 Antibodies), MCT2 (show SLC16A7 Antibodies), and MCT4 (show SLC16A3 Antibodies) are expressed in the PNS. While DRG neurons express MCT1 (show MCTS1 Antibodies), myelinating Schwann cells.
These data for the first time demonstrate that MCT1 (show MCTS1 Antibodies) is critical for regeneration of both sensory and motor axons in mice following sciatic nerve crush
in Parkinson's disease, the levels of MCT1 (show MCTS1 Antibodies), MCT2 (show SLC16A7 Antibodies) and GLUT1 (show SLC2A1 Antibodies) is not changed following dopaminergic neurodegeneration
results suggest that a reduction in mitochondria is a result, rather than the cause, of the metabolic deficiency observed in Basigin-null mice, and likely occurs because of reduced metabolic activity in the absence of MCT1 (show MCTS1 Antibodies) expression.
miR (show MLXIP Antibodies)-29a, miR (show MLXIP Antibodies)-29b selectively target MCT1 (show MCTS1 Antibodies) 3'UTR (show UTS2R Antibodies) ; the miR (show MLXIP Antibodies)-29 isoforms are highly expressed in islets and contribute to silencing Mct1 (show MCTS1 Antibodies) in beta cells; miR (show MLXIP Antibodies)-29 isoforms contribute to beta-cell-specific silencing of the MCT1 (show MCTS1 Antibodies) transporter and may affect insulin (show INS Antibodies) release
monocarboxylate transporter 1 (MCT1), is highly enriched within oligodendroglia and disruption of this transporter produces axon damage and neuron loss in animal and cell culture models; in addition, this same transporter is reduced in patients with, and in mouse models of, amyotrophic lateral sclerosis, suggesting a role for oligodendroglial MCT1 (show MCTS1 Antibodies) in pathogenesis
This study confirmed age-dependent changes of MCT1 (show MCTS1 Antibodies) expression in the rumen epithelium of newborn calves and showed that its expression might be affected by liquid feed type.
These findings show that MCT 1 (show MCTS1 Antibodies) increases with the development of rumen function and also in adult animals MCT 1 (show MCTS1 Antibodies) may change with the feeding.
The expression and distribution of monocarboxylate transporter 1 along the gastrointestinal tract of calves suggest it may play a role in transport of short chain fatty acids and their metabolites.
The results show that monocarboxylate transporter 1 (MCT1) is a major route for short chain fatty acids (SCFA) efflux across the basolateral membrane of bovine large intestine and that it could play a role in the regulation of intracellular pH.
This gene encodes a Na+/H+ antiporter that is a member of the solute carrier family 9. The encoded protein is a plasma membrane transporter that is expressed in the kidney and intestine. This protein plays a central role in regulating pH homeostasis, cell migration and cell volume. This protein may also be involved in tumor growth.
, monocarboxylate transporter 1
, solute carrier family 16 (monocarboxylic acid transporters), member 1
, solute carrier family 16 member 1
, solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
, Na(+)/H(+) exchanger 1
, Na-Li countertransporter
, sodium/hydrogen exchanger 1
, solute carrier family 9 (sodium/hydrogen exchanger), isoform 1 (antiporter, Na+/H+, amiloride sensitive)
, solute carrier family 9 (sodium/hydrogen exchanger), member 1 (antiporter, Na+/H+, amiloride sensitive)
, monocarboxylate transporter 1a
, monocarboxylate transporter 1-like
, solute carrier 16 (monocarboxylic acid transporter), member 1
, Monocarboxylate transporter 1
, monocarboxylate transporter 1-like protein
, solute carrier family 16 (monocarboxylate transporter), member 1