anti-Solute Carrier Family 20 (Phosphate Transporter), Member 1 (SLC20A1) Antibodies

Xenopus laevis Solute Carrier Family 20 (Phosphate Transporter), Member 1 (SLC20A1) interaction partners

1. Cysteine substitution at some sites also altered the apparent affinity for Pi and cation (Na(+)/Li(+)) and substrate (phosphate/arsenate) selectivity, further underscoring the importance of this linker in defining PiT-1 transport characteristics.

Human Solute Carrier Family 20 (Phosphate Transporter), Member 1 (SLC20A1) interaction partners

1. Targeted sequencing of two candidate genes, SLC20A1 and SLC15A4, of the solute carrier membrane transport protein family in 200 additional patients demonstrated two further variants predicted as damaging for combined hormone deficiency.

2. Overexpression of SLC20A1 is associated with Estrogen Receptor-positive Breast Cancer.

3. indoxyl sulfate promotes Pit-1 expression in part by activation of the JNK pathway in vascular smooth muscle cells

4. Ox-LDL induces an osteogenic change in human aortic valve interstitial cells marked by the induction of PiT-1.

5. Overexpression of SLC20A1 promotes apoptosis and mineralization by altering the level of Akt-1.

6. Allelic variations in SLC20A1 were associated with the levels of Sodium-lithium countertransport.

7. the human PiT2 histidine, H(502), and the human PiT1 glutamate, E(70),--both conserved in eukaryotic PiT family members--are critical for P(i) transport function

8. Identification of a novel transport-independent function of PiT1/SLC20A1 in the regulation of TNF-induced apoptosis.

9. propose that region A of Pit1 confers competence for viral entry by influencing the topology of the authentic binding site in the membrane and hence its accessibility to a viral envelope protein

10. Two highly conserved glutamate residues critical for sodium-dependent phosphate transport are revealed by uncoupling transport function from retroviral receptor function.

11. Our results link low-grade IL-8-mediated cartilaginous inflammation in OA to altered chondrocyte differentiation and disease progression through PiT-1 expression and sodium-dependent Pi uptake mediated by CXCR1 signaling.

12. Phosphate uptake through Pit-1 is essential for vascular smooth muscle cell calcification and phenotypic modulation in response to elevated phosphate.

13. Results describe the characterization of transport mechanisms and determinants critical for sodium-dependent phosphate symport of the PiT family paralogs human PiT1 and PiT2.

14. Analysis of kinetics and substrate specificity of SLC20A1.

15. An overexpression of Pit-1 seems to play a key role in the formation of soft tissue calcification in Werner syndrome.

16. PiT1 depletion markedly reduces cell proliferation, delays cell cycle, and impairs mitosis and cytokinesis.

Mouse (Murine) Solute Carrier Family 20 (Phosphate Transporter), Member 1 (SLC20A1) interaction partners

1. These data support the involvement of phosphate transporter 1, hereafter referred to as Pi T-1, in the initiation of skeletal mineralization and provide compelling evidence that PHOSPHO1 function is involved in MV biogenesis

2. propose the novel idea that PiT-1 is central to the regulation of endocytosis and autophagy in the yolk sac visceral endoderm

3. Pi uptake-dependent and -independent functions of PiT-1 are important for vascular smooth muscle cell processes mediating vascular calcification.

4. Mechanistically, PiT-1 and PiT-2 seem to serve redundant roles in phosphate-induced calcification of vascular smooth muscle cells.

5. Data indicate that mice lacking SLC20A1 (PiT1) develop a profound underproduction anemia characterized by mild macrocytosis, dyserythropoiesis, increased apoptosis, and a near complete block in terminal erythroid differentiation.

6. Incisor enamel formation is impaired in transgenic rats overexpressing the type III NaPi transporter Slc20a1.

7. that cellular ATP synthesis consequent to P(i) uptake via Pit-1 plays an important role in chondrocyte apoptosis and mineralization, and that chondrogenesis is ATP-dependent.

8. Identification of a novel transport-independent function of PiT1/SLC20A1 in the regulation of TNF-induced apoptosis.

9. Data illustrate a specific in vivo role for PiT1 by uncovering it as being a critical gene for normal developmental liver growth.

10. investigation of function of piT-1 using transgenic rats: overexpression of piT-1 decreased alkaline phosphatase activity in osteoblasts without influencing bone matrix mineralization or skeletal development

11. Inorganic phosphate effects on Glvr-1 and -2 up-regulation require the presence of calcium and involve ERK signalling pathways.