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Sodium-ion independent, medium affinity carnitine transporter. Additionally we are shipping Solute Carrier Family 22 (Organic Anion Transporter), Member 9 Proteins (4) and many more products for this protein.
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Pravastatin is the first identified OAT7 drug substrate. Substantial inter-individual variability in hepatic OAT7 expression, majorly driven by HNF4alpha (show HNF4A Antibodies), may contribute to pravastatin drug disposition and might affect response.
uptake of steroid sulfates by isolated trophoblasts is mediated by OATP-B (show SLCO2B1 Antibodies) and OAT-4 suggesting a physiological role of both carrier proteins in placental uptake of fetal-derived steroid sulfates.
Both progesterone and activation of PKC (show PRRT2 Antibodies) inhibited hOAT4 activity through redistribution of the transporter from cell surface to the intracellular compartments.
OAT7 is the first liver-specific transporter (show SLC22A7 Antibodies) among members of the organic anion transporters of SLC22 family.
The data provide a model for the concerted action of OAT1 (show KCNK3 Antibodies) mediating apical secretion of glutarate derivatives from proximal tubule cells
The regulatory single nucleotide polymorphism (SNP) of OAT4 found in the promoter region of nephrectomized patients is unlikely to influence mRNA expression or promoter activity of OAT4.
Review summarizes current knowledge on the functional and phenotypic consequences of genetic variation in intestinally, hepatically and renally expressed members of solute carrier (show SERTAD2 Antibodies) family (SLC22) member 9.
Functional differences in steroid uptake of SLC22A9 and SLC02B1 in human placenta are reported.
Human organic anion transporter (show SLC22A6 Antibodies) hOAT4 is a transporter of perfluorooctanoic acid.
This is the first report showing a functional apical OCTN2 in the renal medulla and a functional apical OCTN3 in both renal cortex and medulla.
Results demonstrate that mammalian small intestine expresses OCTN3 mRNA along the villus and that OCTN3 protein is located in the basolateral membrane.
demonstration of expression and colocalization of Octn3 and catalase (show CAT Antibodies) in liver peroxisomes
PPARalpha up-regulates the expression of Slc22a21 in small intestine.
shows that transcriptional upregulation of OCTN2 (show SLC22A5 Antibodies) and OCTN3 in tissues and of enzymes involved in hepatic carnitine biosynthesis are mediated by PPAR alpha (show PPARA Antibodies)
Octn1 (show SLC22A4 Antibodies), -2, and -3 are expressed in many regions of murine heart
Sodium-ion independent, medium affinity carnitine transporter. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 746.
organic anion transporter 4
, organic anion transporter 7
, solute carrier family 22 (organic anion/cation transporter), member 9
, solute carrier family 22 member 9
, solute carrier family 22, member 25