Solute Carrier Family 25, Member 27 Proteins (SLC25A27)

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). Additionally we are shipping SLC25A27 Antibodies (30) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC25A27 9481 O95847
Mouse SLC25A27 SLC25A27 74011  
Rat SLC25A27 SLC25A27 85262  
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Top SLC25A27 Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Log in to see Available
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days

SLC25A27 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,

More Proteins for Solute Carrier Family 25, Member 27 (SLC25A27) Interaction Partners

Human Solute Carrier Family 25, Member 27 (SLC25A27) interaction partners

  1. This study found that the variability of UCP4 does affect the individual susceptibility to Late-Onset Alzheimer's Disease.

  2. UCP4 mRNA of cartilage tissues was decreased in osteoarthritis patients, which was negatively correlated with synovial fluid (SF) leptin (show LEP Proteins) concentration.

  3. Compares and contrasts all the known human SLC25A (show SLC25A25 Proteins)* genes and includes functional information.

  4. UCP4 is a target effector gene of the NF-kappaB (show NFKB1 Proteins) c-Rel (show NFkBP65 Proteins) prosurvival pathway to mitigate the effects of oxidative stress.

  5. Neuronal UCP4 exhibits transmembrane chloride transport activity.

  6. Findings show how UCP4 overexpression increases ATP synthesis by specifically interacting with Complex II.

  7. UCP4 expression correlated with lymph node metastases, positive estrogen/progesterone receptor (show PGR Proteins) expression, and positivity for p53 (show TP53 Proteins) and Ki-67 (show MKI67 Proteins) in breast carcinomas.

  8. A homozygous genetic variant of mitochondrial uncoupling protein 4 affects the occurrence of leukoaraiosis.(

  9. the association found between the ultra-resistant schizophrenia group and the UCP4 haplotype is noteworthy as it may influence treatment outcome in schizophrenia.

  10. has a significant role in NF-kappaB (show NFKB1 Proteins)-mediated prosurvival signaling and cell protection against neurotoxins

Mouse (Murine) Solute Carrier Family 25, Member 27 (SLC25A27) interaction partners

  1. UCP4 may dissipate the excessive proton gradient, which is usually associated with reactive oxygen species production.

  2. astrocytes expressing more UCP4 produce more lactate, which is used as an energy source by neurons, and have the ability to enhance neuronal survival

  3. UCP2 (show UCP2 Proteins) is present in cells with highly proliferative potential, which have a glycolytic type of metabolism as a common feature, whereas UCP4 is strongly associated with non-proliferative highly differentiated neuronal cells

  4. Adipocytes overexpressing UcpP4 showed decreased mitochondrial copy number (mtDNA) and lower mRNA expression of key factors in mitochondrial biogenesis, including PGC-1alpha and mtTFA (show TFAM Proteins).

  5. Results suggest that mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress.

SLC25A27 Protein Profile

Protein Summary

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. Transcripts of this gene are only detected in brain tissue and are specifically modulated by various environmental conditions. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with SLC25A27

  • solute carrier family 25 member 27 (SLC25A27)
  • solute carrier family 25, member 27 (Slc25a27)
  • 3632410G24Rik protein
  • 9430092A03Rik protein
  • D530043E16Rik protein
  • Ucp4 protein

Protein level used designations for SLC25A27

UCP 4 , mitochondrial uncoupling protein 4 , uncoupling protein 4 , uncoupling protein UCP-4

9481 Homo sapiens
609887 Canis lupus familiaris
100157774 Sus scrofa
74011 Mus musculus
85262 Rattus norvegicus
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