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Mitochondrial ADP/ATP carriers, such as SLC25A31, are nuclear-coded mitochondrial proteins that catalyze the exchange of ATP generated in mitochondria by ATP synthase (see MIM 108729) against ADP produced in cytosol by most energy-consuming reactions (Dolce et al., 2005 [PubMed 15670820]).[supplied by OMIM, Mar 2008].. Additionally we are shipping SLC25A31 Antibodies (45) and many more products for this protein.
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Male mice with disruptions of Slc25a31 are sterile and display an early meiotic arrest phenotype.
Compares and contrasts all the known human SLC25A (show SLC25A25 Proteins)* genes and includes functional information.
Data show the specific role of the ANT4 isoform in spermatozoid bioenergetics.
data define common and distinct biochemical characteristics of ANT4 in comparison to ANT1 (show SLC25A4 Proteins), 2 and 3 providing a basis for study of its unique adaptation to germ cells
data highlight a cytoprotective activity of ANT4, and provide a novel dichotomy in the ANT isoform sub-family with ANT1 and 3 isoforms functioning as pro-apoptotic while ANT2 and 4 isoforms render cells resistant to death inducing stimuli
The co-localization of SFEC and glycolytic enzymes in the fibrous sheath supports a growing literature that the principal piece of the flagellum is capable of generating and regulating ATP independently from mitochondrial oxidation in the mid-piece.
Ant4 is a meiosis-specific gene expressed during both male and female gametogenesis however indispensable only during spermatogenesis and not oogenesis.
Studies indicate that Ant4 was expressed selectively in testis and sperm in adult mammals and was indeed essential for mouse spermatogenesis.
Adenine nucleotide translocase 4 deficiency leads to early meiotic arrest of murine male germ cells.
adenine nucleotide translocase 4 is essential for spermatogenesis
Mitochondrial ADP/ATP carriers, such as SLC25A31, are nuclear-coded mitochondrial proteins that catalyze the exchange of ATP generated in mitochondria by ATP synthase (see MIM 108729) against ADP produced in cytosol by most energy-consuming reactions (Dolce et al., 2005
ADP/ATP translocase 4
, solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31
, ADP,ATP carrier protein 4
, ANT 4
, adenine nucleotide translocase 4
, adenine nucleotide translocator 4
, solute carrier family 25 member 31
, sperm flagellar energy carrier protein
, adenine nucleotide translocator), member 31
, adenine nucleotide translocator), member 31-like