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SLC6A2 encodes a member of the sodium symporter family. Additionally we are shipping SLC6A2 Kits (26) and SLC6A2 Proteins (7) and many more products for this protein.
Showing 10 out of 46 products:
Human Polyclonal SLC6A2 Primary Antibody for CM, ICC - ABIN2746956
Wersinger, Jeannotte, Sidhu: Attenuation of the norepinephrine transporter activity and trafficking via interactions with alpha-synuclein. in The European journal of neuroscience 2007
Show all 2 Pubmed References
Cow (Bovine) Polyclonal SLC6A2 Primary Antibody for WB - ABIN2777051
Suzuki, Matsumoto, Oshino, Kamata, Goto, Otani: Combination of the serotonin transporter and norepinephrine transporter gene promoter polymorphisms might influence harm avoidance and novelty seeking in healthy females. in Neuroscience letters 2008
Show all 2 Pubmed References
Mouse (Murine) Monoclonal SLC6A2 Primary Antibody for WB - ABIN447416
Klimek, Stockmeier, Overholser, Meltzer, Kalka, Dilley, Ordway: Reduced levels of norepinephrine transporters in the locus coeruleus in major depression. in The Journal of neuroscience : the official journal of the Society for Neuroscience 1997
genetic association/pharmacogenetic studies in population in Switzerland: Data from controlled studies suggest that SNPs in SLC6A2 (rs1861647, rs2242446, rs36029) weakly moderate acute cardiovascular response to MDMA (methylenedioxymethamphetamine, "ecstasy") and may play minor role in adverse cardiovascular events when MDMA is used recreationally.
Our study indicates that DNA methylation (show HELLS Antibodies) levels of nine CpG sites in NET gene promoter region are not associated with depression and hypertension.
case-control study by genotyping 7 SNPs of SLC6A2, SLC6A3 (show SLC6A3 Antibodies) and DRD2 (show DRD2 Antibodies) in 1034 schizophrenia patients and 1034 controls. No significant difference in the allelic or genotypic frequency was detected between cases and controls
T allele of the SNP rs7194256 in the 3'UTR (show UTS2R Antibodies) of the NET gene is more prevalent in diseases where NET impairment is evident, including essential hypertension, depression, panic disorder and postural orthostatic tachycardia syndrome; mechanism involved may include the creation of a binding site for the miRNA miR (show MLXIP Antibodies)-19-3p, which is, at least in part, regulated by circulating norepinephrine concentrations
Polymorphisms of COMT (show COMT Antibodies) (c.649G>A), MAO-A (show MAOA Antibodies) (c.1460C>T), NET (c.1287G>A) Genes and the Level of Catecholamines, Serotonin in Patients with Parkinson's Disease
NET undergoes extensive constitutive internalization and internalized NET mainly is sorted to Rab11-positive recycling endosomes.
In Major Depressive Disorder patients there seems to be a relationship between the volume of the dorsolateral prefrontal cortex and polymorphism of the SLC6A2 G1287A gene.
This corticotropin releasing factor (show CRH Antibodies)-induced regulation on norepinephrine transporter expression and function may play a role in development of stress-related depression and anxiety
a NET 182C and 5-HTTLPR (show SLC6A4 Antibodies) polymorphism interaction is associated with susceptibility to treatment resistant depression and ECT treatment response in antidepressant resistant depression patients
NET gene variants are not involved in the etiology of recurrent major depressive disorder in Chinese Han population.
Differences in gene expression in the mouse frontal cortex with life-long norepinephrine transporter knock-out were studied using a whole-genome microarray approach
inhibition of p38 MAPK (show MAPK14 Antibodies) or the manipulation of NET-Thr (show TRH Antibodies)(30) motif/phosphorylation via a TAT (show TAT Antibodies) peptide strategy prevents cocaine-induced NET up-regulation, locomotor sensitization, and conditioned place preference
this is the first report which suggests the beneficial effect of modulation of TRPV1 (show TRPV1 Antibodies) receptors and NET in Chronic cerebral hypoperfusion vascular dementia
Norepinephrine transporter has a greater role in determining baseline analgesia and other analgesic effects in mice than serotonin transporter (show SLC6A4 Antibodies).
NET expression is essential for development and/or survival of some (5-HT (show DDC Antibodies)- and calretinin (show CALB2 Antibodies)-expressing), but not all (nNOS (show NOS1 Antibodies)-expressing), of these neurons.
propose that amplified norepinephrine transporter function in rictor (show RICTOR Antibodies) KO mice enhances accumulation of both norepinephrine and dopamine within the noradrenergic neuron
We identified that gene expression in neuronal cortical cells involves increased histone hyperacetylation on the Slc6a2 promoter, which is commensurate with the recruitment of SP1 and RNA Polymerase II and is inversely correlated with H3K9 trimethylation.
Data demonstrate that estrogen exerts significant modulatory effects on olfactory bulb function through modulation of tyrosine hydroxylase (show TH Antibodies), dopamine transporter and norepinephrine transporter expression.
this is the first report to suggest that the norepinephrine transporter gene is one of many possible genetic factors influencing ethanol sensitivity in ILS, ISS, and LXS RI mouse strains
The effects of DAT (show SLC6A3 Antibodies) KO in animal models of depression are larger than those produced by NET or SERT (show SLC6A4 Antibodies) KO, and unlikely to be simply the result of the confounding effects of locomotor hyperactivity.
This gene encodes a member of the sodium symporter family. This member is a multi-pass membrane protein, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis. Mutations in this gene cause orthostatic intolerance, a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.
, norepinephrine transporter
, sodium-dependent noradrenaline transporter
, solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
, solute carrier family 6 member 5
, NE transporter
, solute carrier family 6 member 2
, NaCl-dependent norepinephrine transporter
, neurotransmitter transporter, noradrenal
, transmembrane region 4..26 transmembrane region 55..77 transmembrane region 105..123 transmembrane region 136..157
, norepinephrine plasma membrane transporter
, pulmonary norepinephrine plasma membrane transporter
, sodium-dependent noradrenaline transporter-like
, sodium- and chloride-dependent glycine transporter 2-like
, solute carrier family 6 (neurotransmitter transporter, glycine), member 5